HMGA1 and SSB

Number of citations of the paper that reports this interaction (PMID 18850631)
2

Data Source:
BioGRID (far western blotting)

		HMGA1	SSB
Gene Name		high mobility group AT-hook 1	Sjogren syndrome antigen B (autoantigen La)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytosol Focal Adhesion Senescence-associated Heterochromatin Focus	Nucleus Ribonucleoprotein Complex
	Molecular Function	DNA Binding AT DNA Binding DNA-(apurinic Or Apyrimidinic Site) Lyase Activity Protein Binding Transcription Factor Binding Enzyme Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Retinoid X Receptor Binding 5'-deoxyribose-5-phosphate Lyase Activity	TRNA Binding Nucleotide Binding MRNA Binding Protein Binding Poly(A) RNA Binding
	Biological Process	DNA Catabolic Process, Endonucleolytic DNA Unwinding Involved In DNA Replication Base-excision Repair Nucleosome Disassembly Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Complex Assembly Negative Regulation Of Cell Proliferation Response To Virus Viral Process Negative Regulation Of Chromatin Silencing Senescence-associated Heterochromatin Focus Assembly Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Establishment Of Integrated Proviral Latency Oncogene-induced Cell Senescence Positive Regulation Of Cellular Senescence	TRNA Modification Histone MRNA Metabolic Process
Pathways		DNA Damage/Telomere Stress Induced Senescence Vpr-mediated nuclear import of PICs HIV Infection Cellular Senescence Host Interactions of HIV factors Integration of provirus Interactions of Vpr with host cellular proteins Early Phase of HIV Life Cycle Autointegration results in viral DNA circles HIV Life Cycle Formation of Senescence-Associated Heterochromatin Foci (SAHF) 2-LTR circle formation Integration of viral DNA into host genomic DNA APOBEC3G mediated resistance to HIV-1 infection	RNA Polymerase III Transcription RNA Polymerase III Transcription Termination RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase III Abortive And Retractive Initiation
Drugs
Diseases
GWAS		Body mass index ( 20935630) Height ( 21998595 20881960 19396169 19343178 19893584 23563607 18391951 20397748 20189936)
Protein-Protein Interactions		60 interactors: ANXA1 ANXA2 APEX1 ATF2 CDK1 CEBPB CREBBP CSNK2A1 CSNK2A2 CWC27 DNAJC8 EIF2S2 ELF1 EWSR1 GTF2F2 HIPK2 HMGB1 HMGB2 HMGB3 HNRNPA1 HNRNPAB HNRNPD HNRNPDL HNRNPL HSPA1A IRF1 JUN KAT2B METAP2 NCL NFKB1 NFYA NPM1 OLA1 ORC6 PA2G4 PARP1 PCBP1 PCBP2 POU2F1 POU2F2 POU3F1 PPARG PPP1R8 PRKCA PRMT6 PSIP1 PTBP1 RARA RARG RCC1 RN7SK RNF4 RXRA SP1 SRF SSB SUFU SYNCRIP UPF2	9 interactors: APP CSNK2A1 CSNK2B GZMH HMGA1 IL7R NCL SPIB SPP1
Entrez ID		3159	6741
HPRD ID		02829	00168
Ensembl ID		ENSG00000137309	ENSG00000138385
Uniprot IDs		P17096 Q5T6U8	P05455
PDB IDs		2EZD 2EZE 2EZF 2EZG	1OWX 1S79 1S7A 1YTY 1ZH5 2VOD 2VON 2VOO 2VOP
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Gene Expression Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process MRNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Biosynthetic Process RNA Splicing, Via Transesterification Reactions Negative Regulation Of Gene Expression RNA Splicing Biosynthetic Process Negative Regulation Of Transcription, DNA-templated RNA Processing Transcription Initiation From RNA Polymerase II Promoter MRNA Processing Regulation Of Cell Cycle Viral Process Cell Differentiation Metabolic Process DNA-templated Transcription, Initiation Cellular Response To Organic Substance Developmental Process Regulation Of Cell Differentiation	Chemotaxis Developmental Process Response To External Stimulus Axon Guidance Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Cell Morphogenesis Cell Differentiation Positive Regulation Of Metabolic Process Interleukin-7-mediated Signaling Pathway Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Oncogene-induced Cell Senescence Synaptic Growth At Neuromuscular Junction Positive Regulation Of Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter Locomotion Axonogenesis Anatomical Structure Morphogenesis Axon Development Regulation Of Cell Size Collateral Sprouting In Absence Of Injury Senescence-associated Heterochromatin Focus Assembly Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Growth Cell Growth Neuron Projection Morphogenesis Positive Regulation Of Cellular Senescence System Development Movement Of Cell Or Subcellular Component Positive Regulation Of Gene Expression Generation Of Neurons Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of T Cell Mediated Cytotoxicity Cell Morphogenesis Involved In Differentiation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Neurogenesis Negative Regulation Of Neuron Differentiation Negative Regulation Of Collateral Sprouting Axon Choice Point Recognition Negative Regulation Of Chromatin Silencing Negative Regulation Of Axon Regeneration Positive Regulation Of Activin Receptor Signaling Pathway Establishment Of Integrated Proviral Latency Neuron Projection Development Regulation Of Mitotic Cell Cycle Phase Transition Multicellular Organismal Development Cell Projection Morphogenesis Positive Regulation Of Cell Aging Adiponectin-activated Signaling Pathway Regulation Of Cell Cycle Phase Transition Cell Part Morphogenesis
Tagcloud ?		arresting attribute augments bcl2 concomitantly e2 e6 evidences g0 galactosidase hmgb1 hpv16 htert kb linking mechanistic messaging papilloma re senescence senescent sensitizes shifted siha survivin sustaining tendency tnf tumorigenesis	advocate anticollagen asymptomatic autoantibodies autoantibody blindly cardiolipin certified dealing dsdna ganglioside gm2 harbored israeli la liabilities nc phosphatidylserine polyclonality preponderance pyruvate questioning rheumatological rheumatologist rnp silicone ssa ssdna symptomatic
Tagcloud (Difference) ?		arresting attribute augments bcl2 concomitantly e2 e6 evidences g0 galactosidase hmgb1 hpv16 htert kb linking mechanistic messaging papilloma re senescence senescent sensitizes shifted siha survivin sustaining tendency tnf tumorigenesis	advocate anticollagen asymptomatic autoantibodies autoantibody blindly cardiolipin certified dealing dsdna ganglioside gm2 harbored israeli la liabilities nc phosphatidylserine polyclonality preponderance pyruvate questioning rheumatological rheumatologist rnp silicone ssa ssdna symptomatic
Tagcloud (Intersection) ?