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LILRB1 and HLA-B
Number of citations of the paper that reports this interaction (PMID
12853576
)
72
Data Source:
HPRD
(in vitro)
LILRB1
HLA-B
Gene Name
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
major histocompatibility complex, class I, B
Image
Gene Ontology Annotations
Cellular Component
Extracellular Region
Cytoplasm
Plasma Membrane
External Side Of Plasma Membrane
Integral Component Of Membrane
Golgi Membrane
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
ER To Golgi Transport Vesicle Membrane
Membrane
Integral Component Of Membrane
Phagocytic Vesicle Membrane
Early Endosome Membrane
MHC Class I Protein Complex
Extracellular Vesicular Exosome
Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
Molecular Function
Protein Phosphatase 1 Binding
HLA-A Specific Inhibitory MHC Class I Receptor Activity
HLA-B Specific Inhibitory MHC Class I Receptor Activity
MHC Class I Receptor Activity
SH2 Domain Binding
MHC Class I Protein Binding
Protein Homodimerization Activity
Receptor Binding
Peptide Antigen Binding
TAP Binding
Chaperone Binding
Biological Process
Negative Regulation Of T Cell Mediated Cytotoxicity
Positive Regulation Of Defense Response To Virus By Host
T Cell Proliferation Involved In Immune Response
Negative Regulation Of Cytokine Secretion Involved In Immune Response
Immune Response-inhibiting Cell Surface Receptor Signaling Pathway
Fc Receptor Mediated Inhibitory Signaling Pathway
Signal Transduction
Response To Virus
Positive Regulation Of Gene Expression
Negative Regulation Of Serotonin Secretion
Receptor Internalization
Interferon-gamma Production
Negative Regulation Of Interferon-gamma Production
Negative Regulation Of Mononuclear Cell Proliferation
Negative Regulation Of Interferon-beta Secretion
Negative Regulation Of T Cell Proliferation
Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Interferon-gamma Biosynthetic Process
Negative Regulation Of Cell Cycle
Negative Regulation Of Endocytosis
Positive Regulation Of Cytolysis
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity
Negative Regulation Of Alpha-beta T Cell Activation
Regulation Of Immune Response
Defense Response To Virus
Negative Regulation Of Calcium Ion Transport
Cellular Response To Lipopolysaccharide
Interferon-gamma Secretion
Dendritic Cell Differentiation
Negative Regulation Of Dendritic Cell Apoptotic Process
Negative Regulation Of Interleukin-10 Secretion
Negative Regulation Of Interleukin-12 Secretion
Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation
Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell
Positive Regulation Of Gamma-delta T Cell Activation Involved In Immune Response
Negative Regulation Of Dendritic Cell Differentiation
Negative Regulation Of Transforming Growth Factor-beta Secretion
Negative Regulation Of Osteoclast Development
Positive Regulation Of T Cell Mediated Cytotoxicity
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent
Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent
Regulation Of T Cell Anergy
Defense Response
Immune Response
Viral Process
Detection Of Bacterium
Cytokine-mediated Signaling Pathway
Regulation Of Interleukin-12 Production
Regulation Of Interleukin-6 Production
Protection From Natural Killer Cell Mediated Cytotoxicity
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Innate Immune Response
Regulation Of Immune Response
Interferon-gamma-mediated Signaling Pathway
Type I Interferon Signaling Pathway
Regulation Of Dendritic Cell Differentiation
Pathways
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Adaptive Immune System
Interferon gamma signaling
Interferon Signaling
Endosomal/Vacuolar pathway
Cytokine Signaling in Immune system
Interferon alpha/beta signaling
Class I MHC mediated antigen processing & presentation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen processing-Cross presentation
ER-Phagosome pathway
Adaptive Immune System
Interferon gamma signaling
Interferon Signaling
Endosomal/Vacuolar pathway
Cytokine Signaling in Immune system
Interferon alpha/beta signaling
Class I MHC mediated antigen processing & presentation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen processing-Cross presentation
ER-Phagosome pathway
Adaptive Immune System
Drugs
Diseases
GWAS
Ankylosing spondylitis (
21743469
)
Beta-2 microglubulin plasma levels (
23417110
)
CD4:CD8 lymphocyte ratio (
20045101
)
Cervical cancer (
23482656
)
Drug-induced liver injury (flucloxacillin) (
19483685
)
Epstein-Barr virus immune response (EBNA-1) (
23326239
)
Graves' disease (
21841780
)
Height (
19343178
23563607
)
HIV-1 control (
20205591
21051598
20041166
)
Hypothyroidism (
22493691
)
Multiple sclerosis (
22190364
19525953
)
Nasopharyngeal carcinoma (
20512145
)
Platelet counts (
22139419
)
Visceral adipose tissue adjusted for BMI (
22589738
)
Vitiligo (
20526339
)
White blood cell count (
21738480
)
Protein-Protein Interactions
6 interactors:
B2M
HLA-A
HLA-B
HLA-C
HLA-F
HLA-G
16 interactors:
ARHGEF4
ATF7IP
B2M
CD8A
CSF1
KIR3DL1
KIR3DS1
KLRD1
LILRB1
LILRB2
MAGEA1
SRC
STAT1
TRA
TRB
TRIB3
Entrez ID
10859
3106
HPRD ID
07273
00828
Ensembl ID
ENSG00000104972
ENSG00000234745
Uniprot IDs
A8MVE2
Q8NHL6
E5FQ95
P01889
P30466
S6AU73
PDB IDs
1G0X
1P7Q
1UFU
1UGN
1VDG
3D2U
4LL9
3VCL
4JQV
Enriched GO Terms of Interacting Partners
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Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent
Positive Regulation Of T Cell Mediated Cytotoxicity
Regulation Of T Cell Mediated Cytotoxicity
Positive Regulation Of Leukocyte Mediated Cytotoxicity
Positive Regulation Of T Cell Mediated Immunity
Positive Regulation Of Cell Killing
Regulation Of Leukocyte Mediated Cytotoxicity
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Interferon-gamma-mediated Signaling Pathway
Positive Regulation Of Adaptive Immune Response
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Cellular Response To Interferon-gamma
Response To Interferon-gamma
Regulation Of Adaptive Immune Response
Antigen Processing And Presentation Of Peptide Antigen
Type I Interferon Signaling Pathway
Cellular Response To Type I Interferon
Response To Type I Interferon
Antigen Processing And Presentation
Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent
Cytokine-mediated Signaling Pathway
Cellular Response To Cytokine Stimulus
Positive Regulation Of Immune Response
Response To Cytokine
Innate Immune Response
Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Antigen Processing And Presentation Of Endogenous Antigen
Immune Response
Regulation Of Immune System Process
Defense Response
Protection From Natural Killer Cell Mediated Cytotoxicity
Cellular Response To Organic Substance
Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity
Immune System Process
Response To Organic Substance
Regulation Of Dendritic Cell Differentiation
Viral Process
Cell Surface Receptor Signaling Pathway
Response To Stress
Detection Of Bacterium
Regulation Of Natural Killer Cell Mediated Cytotoxicity
Regulation Of Natural Killer Cell Mediated Immunity
Regulation Of Defense Response To Virus By Virus
Detection Of Biotic Stimulus
Negative Regulation Of Innate Immune Response
Negative Regulation Of Immune System Process
Regulation Of Interleukin-12 Production
Immune Response
Regulation Of Immune Response
Regulation Of Immune System Process
Defense Response
Immune System Process
Innate Immune Response
Leukocyte Differentiation
Response To Molecule Of Bacterial Origin
Cell Activation
Cellular Response To Lipopolysaccharide
Response To Other Organism
Fc Receptor Mediated Inhibitory Signaling Pathway
Cellular Response To Molecule Of Bacterial Origin
Response To Biotic Stimulus
Response To Stress
Immune Response-inhibiting Cell Surface Receptor Signaling Pathway
Response To Bacterium
Immune Response-inhibiting Signal Transduction
Leukocyte Activation
Single Organismal Cell-cell Adhesion
Regulation Of Dendritic Cell Differentiation
Signal Transduction
Cell Surface Receptor Signaling Pathway
Response To Virus
Hemopoiesis
Signaling
Response To Lipopolysaccharide
Cell Communication
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Immune System Development
Cellular Response To Organic Substance
Positive Regulation Of Cell Adhesion
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Negative Regulation Of Biosynthetic Process
Regulation Of Cellular Process
Lymphocyte Activation
Cellular Response To Lipid
Defense Response To Virus
Enzyme Linked Receptor Protein Signaling Pathway
Cellular Response To Stimulus
Positive Regulation Of Immune System Process
Response To Stimulus
Immune Response-regulating Signaling Pathway
Tissue Homeostasis
Negative Regulation Of Cell Adhesion
Viral Process
Positive Regulation Of T Cell Activation
Cellular Response To Insulin Stimulus
Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Homotypic Cell-cell Adhesion
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