LILRB1

Gene Name		leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
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Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Phosphatase 1 Binding HLA-A Specific Inhibitory MHC Class I Receptor Activity HLA-B Specific Inhibitory MHC Class I Receptor Activity MHC Class I Receptor Activity SH2 Domain Binding MHC Class I Protein Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host T Cell Proliferation Involved In Immune Response Negative Regulation Of Cytokine Secretion Involved In Immune Response Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Inhibitory Signaling Pathway Signal Transduction Response To Virus Positive Regulation Of Gene Expression Negative Regulation Of Serotonin Secretion Receptor Internalization Interferon-gamma Production Negative Regulation Of Interferon-gamma Production Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Interferon-beta Secretion Negative Regulation Of T Cell Proliferation Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Interferon-gamma Biosynthetic Process Negative Regulation Of Cell Cycle Negative Regulation Of Endocytosis Positive Regulation Of Cytolysis Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Alpha-beta T Cell Activation Regulation Of Immune Response Defense Response To Virus Negative Regulation Of Calcium Ion Transport Cellular Response To Lipopolysaccharide Interferon-gamma Secretion Dendritic Cell Differentiation Negative Regulation Of Dendritic Cell Apoptotic Process Negative Regulation Of Interleukin-10 Secretion Negative Regulation Of Interleukin-12 Secretion Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Gamma-delta T Cell Activation Involved In Immune Response Negative Regulation Of Dendritic Cell Differentiation Negative Regulation Of Transforming Growth Factor-beta Secretion Negative Regulation Of Osteoclast Development
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS
Protein-protein Interactions		6 interactors: B2M HLA-A HLA-B HLA-C HLA-F HLA-G
Entrez ID		10859
HPRD ID		07273
Ensembl ID		ENSG00000104972
Uniprot IDs		A8MVE2 Q8NHL6
PDB IDs		1G0X 1P7Q 1UFU 1UGN 1VDG 3D2U 4LL9
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Cellular Response To Interferon-gamma Response To Interferon-gamma Regulation Of Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Antigen Processing And Presentation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Positive Regulation Of Immune Response Response To Cytokine Innate Immune Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Regulation Of Immune Response Positive Regulation Of Immune System Process Antigen Processing And Presentation Of Endogenous Antigen Immune Response Regulation Of Immune System Process Defense Response Protection From Natural Killer Cell Mediated Cytotoxicity Cellular Response To Organic Substance Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Immune System Process Response To Organic Substance Regulation Of Dendritic Cell Differentiation Viral Process Cell Surface Receptor Signaling Pathway Response To Stress Detection Of Bacterium Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Defense Response To Virus By Virus Detection Of Biotic Stimulus Negative Regulation Of Innate Immune Response Negative Regulation Of Immune System Process Regulation Of Interleukin-12 Production
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