LILRB1 and HLA-A

Number of citations of the paper that reports this interaction (PMID 12897781)
47

Data Source:
HPRD (in vitro)

		LILRB1	HLA-A
Gene Name		leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	major histocompatibility complex, class I, A
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Golgi Medial Cisterna Plasma Membrane Integral Component Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Extracellular Vesicular Exosome Endoplasmic Reticulum Exit Site Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Phosphatase 1 Binding HLA-A Specific Inhibitory MHC Class I Receptor Activity HLA-B Specific Inhibitory MHC Class I Receptor Activity MHC Class I Receptor Activity SH2 Domain Binding MHC Class I Protein Binding Protein Homodimerization Activity	Receptor Binding Protein Binding Beta-2-microglobulin Binding Peptide Antigen Binding T Cell Receptor Binding Poly(A) RNA Binding TAP Binding
	Biological Process	Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host T Cell Proliferation Involved In Immune Response Negative Regulation Of Cytokine Secretion Involved In Immune Response Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Inhibitory Signaling Pathway Signal Transduction Response To Virus Positive Regulation Of Gene Expression Negative Regulation Of Serotonin Secretion Receptor Internalization Interferon-gamma Production Negative Regulation Of Interferon-gamma Production Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Interferon-beta Secretion Negative Regulation Of T Cell Proliferation Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Interferon-gamma Biosynthetic Process Negative Regulation Of Cell Cycle Negative Regulation Of Endocytosis Positive Regulation Of Cytolysis Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Alpha-beta T Cell Activation Regulation Of Immune Response Defense Response To Virus Negative Regulation Of Calcium Ion Transport Cellular Response To Lipopolysaccharide Interferon-gamma Secretion Dendritic Cell Differentiation Negative Regulation Of Dendritic Cell Apoptotic Process Negative Regulation Of Interleukin-10 Secretion Negative Regulation Of Interleukin-12 Secretion Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Gamma-delta T Cell Activation Involved In Immune Response Negative Regulation Of Dendritic Cell Differentiation Negative Regulation Of Transforming Growth Factor-beta Secretion Negative Regulation Of Osteoclast Development	Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Immune Response Viral Process Detection Of Bacterium Cytokine-mediated Signaling Pathway Positive Regulation Of Interferon-gamma Production Protection From Natural Killer Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Defense Response To Virus By Virus Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Positive Regulation Of Memory T Cell Activation
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System	Interferon gamma signaling Interferon Signaling Endosomal/Vacuolar pathway Cytokine Signaling in Immune system Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Antigen Presentation: Folding, assembly and peptide loading of class I MHC Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System Interferon gamma signaling Interferon Signaling Endosomal/Vacuolar pathway Cytokine Signaling in Immune system Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System
Drugs
Diseases
GWAS			Adverse response to carbamapezine ( 21149285) Beta-2 microglubulin plasma levels ( 23417110) Complement C3 and C4 levels ( 23028341) Crohn's disease ( 22412388) Drug-induced liver injury (amoxicillin-clavulanate) ( 21570397) HIV-1 control ( 20041166) IgA nephropathy ( 22197929) IgE levels ( 22075330) Nasopharyngeal carcinoma ( 19664746 20512145) Vitiligo ( 20410501)
Protein-Protein Interactions		6 interactors: B2M HLA-A HLA-B HLA-C HLA-F HLA-G	25 interactors: APLP2 B2M BCAP31 CALR CANX CD8A DEK DERL1 ERBB2 KIR3DL2 LILRB1 LILRB2 MAGEA1 MAGEA4 MEOX2 PDIA3 PRKAR1A PRKCA SRC STAT3 TAPBP TRA TRB UBB ZDHHC17
Entrez ID		10859	3105
HPRD ID		07273	00826
Ensembl ID		ENSG00000104972	ENSG00000206503
Uniprot IDs		A8MVE2 Q8NHL6	B1PKY1 B2R7U3 P04439 P30443 Q5SUL5
PDB IDs		1G0X 1P7Q 1UFU 1UGN 1VDG 3D2U 4LL9	1W72 2XPG 3BO8 3RL1 3RL2
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Cellular Response To Interferon-gamma Response To Interferon-gamma Regulation Of Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Antigen Processing And Presentation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Positive Regulation Of Immune Response Response To Cytokine Innate Immune Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Regulation Of Immune Response Positive Regulation Of Immune System Process Antigen Processing And Presentation Of Endogenous Antigen Immune Response Regulation Of Immune System Process Defense Response Protection From Natural Killer Cell Mediated Cytotoxicity Cellular Response To Organic Substance Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Immune System Process Response To Organic Substance Regulation Of Dendritic Cell Differentiation Viral Process Cell Surface Receptor Signaling Pathway Response To Stress Detection Of Bacterium Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Defense Response To Virus By Virus Detection Of Biotic Stimulus Negative Regulation Of Innate Immune Response Negative Regulation Of Immune System Process Regulation Of Interleukin-12 Production	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Immune System Process Antigen Processing And Presentation Of Peptide Antigen Defense Response Neurotrophin TRK Receptor Signaling Pathway Signaling Neurotrophin Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Cell Communication Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Immune Response Regulation Of Immune System Process Signal Transduction Homeostatic Process Cellular Response To Organic Substance Response To Stress Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Chemical Homeostasis Regulation Of Immune Response Regulation Of Signaling Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Cell Adhesion Positive Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signal Transduction Response To Stimulus Regulation Of Protein Kinase Activity Fc Receptor Mediated Inhibitory Signaling Pathway Cellular Response To Stimulus Regulation Of Kinase Activity Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Viral Process Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process Cellular Response To Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Immune Response-inhibiting Signal Transduction Response To Growth Factor Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Dendritic Cell Differentiation Negative Regulation Of T Cell Proliferation Protein Transport
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