LILRB1 and HLA-F

Number of citations of the paper that reports this interaction (PubMedID 11169396)
0

Data Source:
HPRD (in vivo)

		LILRB1	HLA-F
Description		leukocyte immunoglobulin like receptor B1	major histocompatibility complex, class I, F
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane External Side Of Plasma Membrane Membrane	Golgi Membrane Extracellular Space Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class Ib Protein Complex MHC Class I Protein Complex Recycling Endosome Membrane Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Amyloid-beta Binding Protein Binding Protein Phosphatase 1 Binding MHC Class Ib Protein Complex Binding MHC Class Ib Protein Binding HLA-A Specific Inhibitory MHC Class I Receptor Activity HLA-B Specific Inhibitory MHC Class I Receptor Activity MHC Class I Receptor Activity MHC Class Ib Receptor Activity Inhibitory MHC Class I Receptor Activity SH2 Domain Binding MHC Class I Protein Binding Protein Homodimerization Activity	Signaling Receptor Binding Protein Binding Beta-2-microglobulin Binding Peptide Antigen Binding TAP1 Binding TAP2 Binding 14-3-3 Protein Binding
	Biological Process	Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Adaptive Immune Response T Cell Proliferation Involved In Immune Response Immune System Process Negative Regulation Of Cytokine Production Involved In Immune Response Immune Response-regulating Signaling Pathway Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Inhibitory Signaling Pathway Signal Transduction Cell Surface Receptor Signaling Pathway Response To Virus Positive Regulation Of Gene Expression Negative Regulation Of Serotonin Secretion Receptor Internalization Negative Regulation Of Interferon-beta Production Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Type II Interferon Production Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Negative Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Alpha-beta T Cell Activation Defense Response To Virus Negative Regulation Of Calcium Ion Transport Positive Regulation Of Macrophage Cytokine Production Cellular Response To Lipopolysaccharide Negative Regulation Of Transforming Growth Factor Beta Production Dendritic Cell Differentiation Interleukin-10-mediated Signaling Pathway Negative Regulation Of Dendritic Cell Apoptotic Process Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Gamma-delta T Cell Activation Involved In Immune Response Negative Regulation Of Dendritic Cell Differentiation Negative Regulation Of Osteoclast Development	Positive Regulation Of T Cell Mediated Cytotoxicity Immune System Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Negative Regulation Of T Cell Cytokine Production Negative Regulation Of Natural Killer Cell Cytokine Production Positive Regulation Of Natural Killer Cell Cytokine Production Immune Response Negative Regulation Of Natural Killer Cell Degranulation Positive Regulation Of Natural Killer Cell Degranulation Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Interferon gamma signaling Interferon alpha/beta signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Clozapine-induced agranulocytosis ( 25187353)	Albumin-globulin ratio ( 29403010) Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 22412388) Hip circumference adjusted for BMI ( 34021172) Lung cancer ( 31577861) Mixed cellularity Hodgkin lymphoma ( 29196614) Nasopharyngeal carcinoma ( 19664746) Offspring birth weight ( 31043758)
Interacting Genes		7 interacting genes: B2M HLA-A HLA-B HLA-C HLA-F HLA-G SNCA	5 interacting genes: B2M CHRM5 LILRB1 LILRB2 TAP1
Entrez ID		10859	3134
HPRD ID		07273	00884
Ensembl ID		ENSG00000104972	ENSG00000204642
Uniprot IDs		A0A087WSV6 A0A087WSX8 A0A0B4J1W1 A0A0G2JNM2 A0A0G2JP64 A0A0G2JQ15 A8MVE2 D9IDM5 Q8NHL6	A0A0G2JH66 D0EV57 P30511 Q5JZ47 Q5JZ48
PDB IDs		1G0X 1P7Q 1UFU 1UGN 1VDG 3D2U 4LL9 4NO0 5KNM 6AEE 6EWA 6EWC 6EWO 6K60 6ZDX 7KFK	5IUE 5KNM
Enriched GO Terms of Interacting Partners?		MHC Class I Protein Complex Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Antigen Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib ER To Golgi Transport Vesicle Membrane Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Phagocytic Vesicle Membrane Regulation Of Leukocyte Mediated Cytotoxicity Antigen Processing And Presentation Recycling Endosome Membrane Lumenal Side Of Endoplasmic Reticulum Membrane Regulation Of T Cell Mediated Immunity Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Lymphocyte Mediated Immunity Early Endosome Membrane Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Adaptive Immune Response TAP Binding Positive Regulation Of Immune Effector Process Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity External Side Of Plasma Membrane Protection From Natural Killer Cell Mediated Cytotoxicity Golgi Membrane Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Immune Response Adaptive Immune Response Extracellular Space Negative Regulation Of Innate Immune Response Regulation Of Immune System Process Regulation Of Defense Response Regulation Of Cytokine Production Involved In Immune Response Signaling Receptor Binding Immune System Process Regulation Of Immune Response Regulation Of Innate Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of T Cell Cytokine Production	MHC Class Ib Protein Binding MHC Class I Protein Binding MHC Class Ib Protein Complex Binding Adaptive Immune Response Fc Receptor Mediated Inhibitory Signaling Pathway Inhibitory MHC Class I Receptor Activity MHC Class I Peptide Loading Complex Peptide Antigen Assembly With MHC Class I Protein Complex Negative Regulation Of Monoatomic Ion Transport Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Interleukin-10-mediated Signaling Pathway Immune Response-inhibiting Signal Transduction Regulation Of Dendritic Cell Differentiation Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Protein Homodimerization Activity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Protein Phosphatase 1 Binding Antigen Processing And Presentation Of Endogenous Antigen Positive Regulation Of T Cell Activation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Positive Regulation Of Leukocyte Cell-cell Adhesion Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Regulation Of Metal Ion Transport Negative Regulation Of Calcium Ion Transport Immune Response Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Antigen Processing And Presentation Of Peptide Antigen Regulation Of Monoatomic Ion Transport Negative Regulation Of Transport Regulation Of Hemopoiesis Negative Regulation Of Endocytosis Defense Response Cellular Response To Lipid Negative Regulation Of T Cell Proliferation Phagocytic Vesicle Membrane Positive Regulation Of Cytokine Production Positive Regulation Of Cell Adhesion Positive Regulation Of Cytokine Production Involved In Immune Response Regulation Of Cell-cell Adhesion Amyloid-beta Binding Regulation Of Lymphocyte Activation Negative Regulation Of Lymphocyte Proliferation
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