LILRB1 and HLA-C

Number of citations of the paper that reports this interaction (PMID 12853576)
72

Data Source:
HPRD (in vitro)

		LILRB1	HLA-C
Gene Name		leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	major histocompatibility complex, class I, C
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Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane	Golgi Membrane Extracellular Region Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Phosphatase 1 Binding HLA-A Specific Inhibitory MHC Class I Receptor Activity HLA-B Specific Inhibitory MHC Class I Receptor Activity MHC Class I Receptor Activity SH2 Domain Binding MHC Class I Protein Binding Protein Homodimerization Activity	Receptor Binding Peptide Antigen Binding TAP Binding
	Biological Process	Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host T Cell Proliferation Involved In Immune Response Negative Regulation Of Cytokine Secretion Involved In Immune Response Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Inhibitory Signaling Pathway Signal Transduction Response To Virus Positive Regulation Of Gene Expression Negative Regulation Of Serotonin Secretion Receptor Internalization Interferon-gamma Production Negative Regulation Of Interferon-gamma Production Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Interferon-beta Secretion Negative Regulation Of T Cell Proliferation Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Interferon-gamma Biosynthetic Process Negative Regulation Of Cell Cycle Negative Regulation Of Endocytosis Positive Regulation Of Cytolysis Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Alpha-beta T Cell Activation Regulation Of Immune Response Defense Response To Virus Negative Regulation Of Calcium Ion Transport Cellular Response To Lipopolysaccharide Interferon-gamma Secretion Dendritic Cell Differentiation Negative Regulation Of Dendritic Cell Apoptotic Process Negative Regulation Of Interleukin-10 Secretion Negative Regulation Of Interleukin-12 Secretion Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Gamma-delta T Cell Activation Involved In Immune Response Negative Regulation Of Dendritic Cell Differentiation Negative Regulation Of Transforming Growth Factor-beta Secretion Negative Regulation Of Osteoclast Development	Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Immune Response Viral Process Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System	Interferon gamma signaling Interferon Signaling Endosomal/Vacuolar pathway Cytokine Signaling in Immune system Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System
Drugs
Diseases
GWAS			AIDS progression ( 19115949) Atopic dermatitis ( 23042114) Beta-2 microglubulin plasma levels ( 23417110) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Complement C3 and C4 levels ( 23028341) Coronary heart disease ( 22319020) Crohn's disease ( 23128233) Height ( 23563607) HIV-1 control ( 21051598 20041166) Hypothyroidism ( 22493691) Nasopharyngeal carcinoma ( 20512145) Protein quantitative trait loci ( 18464913) Psoriasis ( 20953188 20953190 18369459 18364390 19169254) Psoriatic arthritis ( 20953186) Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) ( 21912425) Vitiligo ( 20526339) White blood cell count ( 21738480)
Protein-Protein Interactions		6 interactors: B2M HLA-A HLA-B HLA-C HLA-F HLA-G	20 interactors: B2M BATF2 CALR CD8A CDC25A CXCR4 HSPA5 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS2 KIR2DS4 LILRB1 LILRB2 PRRG4 TANK TAP2 TAPBP YBX1
Entrez ID		10859	3107
HPRD ID		07273	00829
Ensembl ID		ENSG00000104972	ENSG00000204525
Uniprot IDs		A8MVE2 Q8NHL6	O19617 P10321 Q6R739 Q95HC2
PDB IDs		1G0X 1P7Q 1UFU 1UGN 1VDG 3D2U 4LL9	3BZF
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Cellular Response To Interferon-gamma Response To Interferon-gamma Regulation Of Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Antigen Processing And Presentation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Positive Regulation Of Immune Response Response To Cytokine Innate Immune Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Regulation Of Immune Response Positive Regulation Of Immune System Process Antigen Processing And Presentation Of Endogenous Antigen Immune Response Regulation Of Immune System Process Defense Response Protection From Natural Killer Cell Mediated Cytotoxicity Cellular Response To Organic Substance Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Immune System Process Response To Organic Substance Regulation Of Dendritic Cell Differentiation Viral Process Cell Surface Receptor Signaling Pathway Response To Stress Detection Of Bacterium Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Defense Response To Virus By Virus Detection Of Biotic Stimulus Negative Regulation Of Innate Immune Response Negative Regulation Of Immune System Process Regulation Of Interleukin-12 Production	Immune System Process Regulation Of Immune System Process Regulation Of Immune Response Immune Response Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Immune Response-inhibiting Signal Transduction Defense Response Response To Biotic Stimulus Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Response To Stress Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Fc Receptor Mediated Inhibitory Signaling Pathway Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Cell Activation Response To Other Organism Regulation Of Dendritic Cell Differentiation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Peptide Antigen Response To Stimulus Leukocyte Activation Antigen Processing And Presentation Of Endogenous Antigen Single Organismal Cell-cell Adhesion Positive Regulation Of Immune System Process T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Leukocyte Differentiation Lymphocyte Activation Innate Immune Response Response To External Stimulus Immune Response-regulating Signaling Pathway Dendritic Cell Differentiation Negative Regulation Of Calcium Ion Transport Peptide Antigen Assembly With MHC Class I Protein Complex Cytotoxic T Cell Differentiation Natural Killer Cell Inhibitory Signaling Pathway Regulation Of Protein Folding In Endoplasmic Reticulum Negative Regulation Of Interferon-beta Secretion Peptide Antigen Stabilization Negative Regulation Of Transforming Growth Factor-beta Secretion Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation Positive Regulation Of Gamma-delta T Cell Activation Involved In Immune Response Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Signal Transduction
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