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LILRB1 and HLA-G
Number of citations of the paper that reports this interaction (PMID
12853576
)
72
Data Source:
HPRD
(in vivo, in vitro)
LILRB1
HLA-G
Gene Name
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
major histocompatibility complex, class I, G
Image
Gene Ontology Annotations
Cellular Component
Extracellular Region
Cytoplasm
Plasma Membrane
External Side Of Plasma Membrane
Integral Component Of Membrane
Golgi Membrane
Plasma Membrane
ER To Golgi Transport Vesicle Membrane
Membrane
Phagocytic Vesicle Membrane
Early Endosome Membrane
MHC Class I Protein Complex
Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
Molecular Function
Protein Phosphatase 1 Binding
HLA-A Specific Inhibitory MHC Class I Receptor Activity
HLA-B Specific Inhibitory MHC Class I Receptor Activity
MHC Class I Receptor Activity
SH2 Domain Binding
MHC Class I Protein Binding
Protein Homodimerization Activity
Receptor Binding
Peptide Antigen Binding
Protein Homodimerization Activity
Biological Process
Negative Regulation Of T Cell Mediated Cytotoxicity
Positive Regulation Of Defense Response To Virus By Host
T Cell Proliferation Involved In Immune Response
Negative Regulation Of Cytokine Secretion Involved In Immune Response
Immune Response-inhibiting Cell Surface Receptor Signaling Pathway
Fc Receptor Mediated Inhibitory Signaling Pathway
Signal Transduction
Response To Virus
Positive Regulation Of Gene Expression
Negative Regulation Of Serotonin Secretion
Receptor Internalization
Interferon-gamma Production
Negative Regulation Of Interferon-gamma Production
Negative Regulation Of Mononuclear Cell Proliferation
Negative Regulation Of Interferon-beta Secretion
Negative Regulation Of T Cell Proliferation
Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Interferon-gamma Biosynthetic Process
Negative Regulation Of Cell Cycle
Negative Regulation Of Endocytosis
Positive Regulation Of Cytolysis
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity
Negative Regulation Of Alpha-beta T Cell Activation
Regulation Of Immune Response
Defense Response To Virus
Negative Regulation Of Calcium Ion Transport
Cellular Response To Lipopolysaccharide
Interferon-gamma Secretion
Dendritic Cell Differentiation
Negative Regulation Of Dendritic Cell Apoptotic Process
Negative Regulation Of Interleukin-10 Secretion
Negative Regulation Of Interleukin-12 Secretion
Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation
Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell
Positive Regulation Of Gamma-delta T Cell Activation Involved In Immune Response
Negative Regulation Of Dendritic Cell Differentiation
Negative Regulation Of Transforming Growth Factor-beta Secretion
Negative Regulation Of Osteoclast Development
Positive Regulation Of T Cell Mediated Cytotoxicity
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent
Positive Regulation Of T Cell Tolerance Induction
Immune Response-inhibiting Cell Surface Receptor Signaling Pathway
Cellular Defense Response
Cytokine-mediated Signaling Pathway
Positive Regulation Of Interleukin-12 Production
Negative Regulation Of T Cell Proliferation
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Positive Regulation Of Regulatory T Cell Differentiation
Regulation Of Immune Response
Interferon-gamma-mediated Signaling Pathway
Type I Interferon Signaling Pathway
Negative Regulation Of Dendritic Cell Differentiation
Pathways
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Adaptive Immune System
Interferon gamma signaling
Interferon Signaling
Endosomal/Vacuolar pathway
Cytokine Signaling in Immune system
Interferon alpha/beta signaling
Class I MHC mediated antigen processing & presentation
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Antigen processing-Cross presentation
ER-Phagosome pathway
Adaptive Immune System
Drugs
Diseases
GWAS
Crohn's disease (
22412388
)
IgE levels (
22075330
)
Rheumatoid arthritis (
21653640
)
Protein-Protein Interactions
6 interactors:
B2M
HLA-A
HLA-B
HLA-C
HLA-F
HLA-G
9 interactors:
B2M
CD8A
COPB1
KIR2DL4
KLRD1
LILRB1
LILRB2
TAP1
TAP2
Entrez ID
10859
3135
HPRD ID
07273
00834
Ensembl ID
ENSG00000104972
ENSG00000204632
Uniprot IDs
A8MVE2
Q8NHL6
P17693
Q29897
Q31611
Q5RJ85
Q6DU14
PDB IDs
1G0X
1P7Q
1UFU
1UGN
1VDG
3D2U
4LL9
1YDP
2D31
2DYP
3BZE
3CDG
3CII
3KYN
3KYO
Enriched GO Terms of Interacting Partners
?
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent
Positive Regulation Of T Cell Mediated Cytotoxicity
Regulation Of T Cell Mediated Cytotoxicity
Positive Regulation Of Leukocyte Mediated Cytotoxicity
Positive Regulation Of T Cell Mediated Immunity
Positive Regulation Of Cell Killing
Regulation Of Leukocyte Mediated Cytotoxicity
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Interferon-gamma-mediated Signaling Pathway
Positive Regulation Of Adaptive Immune Response
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Cellular Response To Interferon-gamma
Response To Interferon-gamma
Regulation Of Adaptive Immune Response
Antigen Processing And Presentation Of Peptide Antigen
Type I Interferon Signaling Pathway
Cellular Response To Type I Interferon
Response To Type I Interferon
Antigen Processing And Presentation
Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent
Cytokine-mediated Signaling Pathway
Cellular Response To Cytokine Stimulus
Positive Regulation Of Immune Response
Response To Cytokine
Innate Immune Response
Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Antigen Processing And Presentation Of Endogenous Antigen
Immune Response
Regulation Of Immune System Process
Defense Response
Protection From Natural Killer Cell Mediated Cytotoxicity
Cellular Response To Organic Substance
Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity
Immune System Process
Response To Organic Substance
Regulation Of Dendritic Cell Differentiation
Viral Process
Cell Surface Receptor Signaling Pathway
Response To Stress
Detection Of Bacterium
Regulation Of Natural Killer Cell Mediated Cytotoxicity
Regulation Of Natural Killer Cell Mediated Immunity
Regulation Of Defense Response To Virus By Virus
Detection Of Biotic Stimulus
Negative Regulation Of Innate Immune Response
Negative Regulation Of Immune System Process
Regulation Of Interleukin-12 Production
Regulation Of Immune System Process
Defense Response
Cytosol To ER Transport
Regulation Of Immune Response
Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent
Fc Receptor Mediated Inhibitory Signaling Pathway
Intracellular Transport Of Viral Protein In Host Cell
Immune Response-inhibiting Cell Surface Receptor Signaling Pathway
Immune System Process
Immune Response-inhibiting Signal Transduction
Antigen Processing And Presentation
Regulation Of Dendritic Cell Differentiation
Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Endogenous Antigen
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Single Organismal Cell-cell Adhesion
Viral Process
Response To Stress
Intracellular Transport Of Virus
Immune Response
Antigen Processing And Presentation Of Peptide Antigen
Response To Other Organism
Response To Biotic Stimulus
Negative Regulation Of Calcium Ion Transport
T Cell Aggregation
T Cell Activation
Lymphocyte Aggregation
Leukocyte Aggregation
Cellular Defense Response
Leukocyte Cell-cell Adhesion
Homotypic Cell-cell Adhesion
Leukocyte Differentiation
Response To Molecule Of Bacterial Origin
Positive Regulation Of Immune System Process
Negative Regulation Of T Cell Proliferation
Negative Regulation Of Lymphocyte Proliferation
Negative Regulation Of Mononuclear Cell Proliferation
Negative Regulation Of Leukocyte Proliferation
Negative Regulation Of Transforming Growth Factor-beta Secretion
Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation
Positive Regulation Of Gamma-delta T Cell Activation Involved In Immune Response
Cytotoxic T Cell Differentiation
Negative Regulation Of Interferon-beta Secretion
Lymphocyte Activation
Regulation Of Defense Response To Virus
Regulation Of T Cell Mediated Cytotoxicity
Peptide Transport
Negative Regulation Of Ion Transport
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