LILRB1 and HLA-G

Number of citations of the paper that reports this interaction (PubMedID 12853576)
38

Data Source:
HPRD (in vitro, in vivo)

		LILRB1	HLA-G
Description		leukocyte immunoglobulin like receptor B1	major histocompatibility complex, class I, G
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane External Side Of Plasma Membrane Membrane	Golgi Membrane Extracellular Region Extracellular Space Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Filopodium Membrane Early Endosome Membrane Cis-Golgi Network Membrane MHC Class I Protein Complex Cell Projection Recycling Endosome Membrane Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Amyloid-beta Binding Protein Binding Protein Phosphatase 1 Binding MHC Class Ib Protein Complex Binding MHC Class Ib Protein Binding HLA-A Specific Inhibitory MHC Class I Receptor Activity HLA-B Specific Inhibitory MHC Class I Receptor Activity MHC Class I Receptor Activity MHC Class Ib Receptor Activity Inhibitory MHC Class I Receptor Activity SH2 Domain Binding MHC Class I Protein Binding Protein Homodimerization Activity	Signaling Receptor Binding Protein Binding Peptide Antigen Binding CD8 Receptor Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Adaptive Immune Response T Cell Proliferation Involved In Immune Response Immune System Process Negative Regulation Of Cytokine Production Involved In Immune Response Immune Response-regulating Signaling Pathway Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Inhibitory Signaling Pathway Signal Transduction Cell Surface Receptor Signaling Pathway Response To Virus Positive Regulation Of Gene Expression Negative Regulation Of Serotonin Secretion Receptor Internalization Negative Regulation Of Interferon-beta Production Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Type II Interferon Production Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Negative Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Alpha-beta T Cell Activation Defense Response To Virus Negative Regulation Of Calcium Ion Transport Positive Regulation Of Macrophage Cytokine Production Cellular Response To Lipopolysaccharide Negative Regulation Of Transforming Growth Factor Beta Production Dendritic Cell Differentiation Interleukin-10-mediated Signaling Pathway Negative Regulation Of Dendritic Cell Apoptotic Process Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Gamma-delta T Cell Activation Involved In Immune Response Negative Regulation Of Dendritic Cell Differentiation Negative Regulation Of Osteoclast Development	Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Immune System Process Peripheral B Cell Tolerance Induction Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Positive Regulation Of Tolerance Induction Positive Regulation Of T Cell Tolerance Induction Positive Regulation Of Natural Killer Cell Cytokine Production Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Immune Response Cellular Defense Response Negative Regulation Of Angiogenesis Positive Regulation Of Interleukin-12 Production Negative Regulation Of T Cell Proliferation Protection From Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Immune Response Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Macrophage Cytokine Production Protein Homotrimerization Negative Regulation Of G0 To G1 Transition Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Cellular Senescence Negative Regulation Of Dendritic Cell Differentiation
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Interferon gamma signaling Interferon alpha/beta signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Clozapine-induced agranulocytosis ( 25187353)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Childhood ear infection ( 27182965) Colorectal cancer ( 30529582) Crohn's disease ( 22412388) Eosinophil percentage of white cells ( 32888494) Glaucoma (primary open-angle) ( 33627673) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) IgE levels ( 22075330) IgM levels ( 28628107) LDL cholesterol levels ( 32203549) Lung adenocarcinoma ( 28604730) Lung cancer ( 31577861) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Smoking status (ever vs never smokers) ( 30643258) Takayasu arteritis ( 25604533 33308445) Triglyceride levels ( 32203549) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		7 interacting genes: B2M HLA-A HLA-B HLA-C HLA-F HLA-G SNCA	10 interacting genes: B2M CD8A CDC42 COPB1 KIR2DL4 KLRD1 LILRB1 LILRB2 TAP1 TAP2
Entrez ID		10859	3135
HPRD ID		07273	00834
Ensembl ID		ENSG00000104972	ENSG00000204632
Uniprot IDs		A0A087WSV6 A0A087WSX8 A0A0B4J1W1 A0A0G2JNM2 A0A0G2JP64 A0A0G2JQ15 A8MVE2 D9IDM5 Q8NHL6	A0A0G2JNX1 P17693 Q31611 Q5RJ85 Q6DU14 Q8MH48
PDB IDs		1G0X 1P7Q 1UFU 1UGN 1VDG 3D2U 4LL9 4NO0 5KNM 6AEE 6EWA 6EWC 6EWO 6K60 6ZDX 7KFK	1YDP 2D31 2DYP 3BZE 3CDG 3CII 3KYN 3KYO 6AEE 6K60
Enriched GO Terms of Interacting Partners?		MHC Class I Protein Complex Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Antigen Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib ER To Golgi Transport Vesicle Membrane Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Phagocytic Vesicle Membrane Regulation Of Leukocyte Mediated Cytotoxicity Antigen Processing And Presentation Recycling Endosome Membrane Lumenal Side Of Endoplasmic Reticulum Membrane Regulation Of T Cell Mediated Immunity Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Lymphocyte Mediated Immunity Early Endosome Membrane Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Adaptive Immune Response TAP Binding Positive Regulation Of Immune Effector Process Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity External Side Of Plasma Membrane Protection From Natural Killer Cell Mediated Cytotoxicity Golgi Membrane Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Immune Response Adaptive Immune Response Extracellular Space Negative Regulation Of Innate Immune Response Regulation Of Immune System Process Regulation Of Defense Response Regulation Of Cytokine Production Involved In Immune Response Signaling Receptor Binding Immune System Process Regulation Of Immune Response Regulation Of Innate Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of T Cell Cytokine Production	MHC Class Ib Protein Binding Adaptive Immune Response MHC Class I Protein Binding Regulation Of Leukocyte Mediated Cytotoxicity MHC Class I Peptide Loading Complex Regulation Of T Cell Mediated Cytotoxicity Peptide Antigen Assembly With MHC Class I Protein Complex Regulation Of Lymphocyte Mediated Immunity Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Peptide Transmembrane Transporter Activity ABC-type Peptide Antigen Transporter Activity TAP Complex MHC Class Ib Protein Complex Binding Positive Regulation Of Immune Effector Process Regulation Of Immune Response Regulation Of T Cell Mediated Immunity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Immune System Process Antigen Processing And Presentation Of Endogenous Antigen Lymphocyte Mediated Immunity Positive Regulation Of Lymphocyte Mediated Immunity ABC-type Peptide Transporter Activity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I T Cell Mediated Immunity Peptide Antigen Binding Positive Regulation Of Immune Response Leukocyte Mediated Immunity Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class Ib TAP1 Binding Immune System Process Immune Effector Process Immune Response-regulating Signaling Pathway Cytosol To Endoplasmic Reticulum Transport Fc Receptor Mediated Inhibitory Signaling Pathway Regulation Of Natural Killer Cell Mediated Cytotoxicity MHC Class Ib Receptor Activity Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Adaptive Immune Response MHC Class I Protein Complex Binding MHC Protein Binding Inhibitory MHC Class I Receptor Activity Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Regulation Of Immune System Process Immune Response-inhibiting Cell Surface Receptor Signaling Pathway
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