HLA-DMA and HLA-DMB

Number of citations of the paper that reports this interaction (PubMedID 8574855)
0

Data Source:
HPRD (in vivo)

		HLA-DMA	HLA-DMB
Description		major histocompatibility complex, class II, DM alpha	major histocompatibility complex, class II, DM beta
Image
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Cell Surface Membrane Late Endosome Membrane MHC Class II Protein Complex	Lysosome Lysosomal Membrane Endosome Membrane Late Endosome Membrane MHC Class II Protein Complex
	Molecular Function	Protein Binding MHC Class II Protein Complex Binding Peptide Antigen Binding	Protein Binding MHC Class II Protein Complex Binding Peptide Antigen Binding
	Biological Process	Adaptive Immune Response Immune System Process Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Immune Response Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation	Adaptive Immune Response Immune System Process MHC Class II Protein Complex Assembly Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Immune Response Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of T Cell Proliferation Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell
Pathways		MHC class II antigen presentation	MHC class II antigen presentation
Drugs
Diseases		Allograft rejection
GWAS		Appendicular lean mass ( 33097823) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848)	A body shape index ( 34021172) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Dermatomyositis ( 27153935) Lung cancer ( 28604730) Rosacea symptom severity ( 29771307) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Schizophrenia ( 30285260) Squamous cell lung carcinoma ( 28604730) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		8 interacting genes: B3GAT1 CD74 CD82 HLA-DMB HLA-DOA HLA-DRA HLA-DRB1 U2AF2	11 interacting genes: CD63 CD74 CD82 CUL3 DPM2 HLA-DMA HLA-DOB HLA-DRA MDM2 PSEN2 TEAD1
Entrez ID		3108	3109
HPRD ID		00830	00831
Ensembl ID		ENSG00000204257	ENSG00000242574
Uniprot IDs		P28067 Q31604 Q6ICR9	A0A1V0E3P2 P28068
PDB IDs		1HDM 2BC4 4FQX 4GBX 4I0P	1HDM 2BC4 4FQX 4GBX 4I0P
Enriched GO Terms of Interacting Partners?		MHC Class II Protein Complex MHC Class II Protein Complex Binding Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Antigen Processing And Presentation Of Exogenous Antigen Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Peptide Antigen Binding MHC Class II Receptor Activity Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Adaptive Immune Response Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Endogenous Antigen Lysosomal Membrane Lumenal Side Of Endoplasmic Reticulum Membrane Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Late Endosome Membrane Myeloid Dendritic Cell Antigen Processing And Presentation Lysosome Regulation Of T Cell Differentiation Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Transport Vesicle Membrane Regulation Of Lymphocyte Differentiation Dendritic Cell Antigen Processing And Presentation ER To Golgi Transport Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Regulation Of Cell Activation Protein-containing Complex Assembly Positive Regulation Of Immune Effector Process Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Endocytic Vesicle Membrane Positive Regulation Of Immune Response Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Autolysosome Membrane CD4 Receptor Binding Positive Regulation Of Memory T Cell Differentiation Protein-containing Complex Organization Endosome Positive Regulation Of Monocyte Differentiation Regulation Of Cell Adhesion	MHC Class II Protein Complex MHC Class II Protein Complex Binding Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Antigen Processing And Presentation Of Exogenous Antigen Antigen Processing And Presentation Of Peptide Antigen Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Peptide Antigen Binding Late Endosome Membrane Lysosomal Membrane Protein-containing Complex Assembly Protein-containing Complex Organization Lysosome Positive Regulation Of Cell Adhesion Endocytic Vesicle Membrane MHC Class II Receptor Activity Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Adaptive Immune Response Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Endosome Regulation Of Cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Antigen Processing And Presentation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Antigen Processing And Presentation Of Endogenous Antigen Lumenal Side Of Endoplasmic Reticulum Membrane Cellular Component Assembly Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Multivesicular Body Transport Vesicle Membrane Pigment Granule Maturation Cell Surface MHC Class II Protein Binding, Via Antigen Binding Groove NOS2-CD74 Complex Regulation Of Cell Activation Macrophage Migration Inhibitory Factor Signaling Pathway Positive Regulation Of Immune Response ER To Golgi Transport Vesicle Membrane
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