HLA-DMA and CD74

Number of citations of the paper that reports this interaction (PMID 8574855)
30

Data Source:
HPRD (in vivo)

		HLA-DMA	CD74
Gene Name		major histocompatibility complex, class II, DM alpha	CD74 molecule, major histocompatibility complex, class II invariant chain
Image
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Multivesicular Body Cell Surface Membrane Integral Component Of Membrane Late Endosome Membrane MHC Class II Protein Complex Extracellular Vesicular Exosome	Golgi Membrane Intracellular Lysosomal Membrane Multivesicular Body Vacuole Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Integral Component Of Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane Macrophage Migration Inhibitory Factor Receptor Complex NOS2-CD74 Complex MHC Class II Protein Complex Lysosomal Lumen Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	MHC Class II Protein Complex Binding	Beta-amyloid Binding Cytokine Receptor Activity Protein Binding Cytokine Binding MHC Class II Protein Complex Binding Macrophage Migration Inhibitory Factor Binding MHC Class II Protein Binding MHC Class II Protein Binding, Via Antigen Binding Groove Identical Protein Binding Protein Binding Involved In Protein Folding Nitric-oxide Synthase Binding
	Biological Process	Peptide Antigen Assembly With MHC Class II Protein Complex Protein Transport Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Thymic T Cell Selection Positive Regulation Of T Cell Differentiation Inner Ear Development Positive Regulation Of Immune Response Chaperone Mediated Protein Folding Requiring Cofactor	Activation Of MAPK Activity Prostaglandin Biosynthetic Process Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Negative Regulation Of Peptide Secretion Positive Regulation Of Type 2 Immune Response Negative Regulation Of Mature B Cell Apoptotic Process Protein Complex Assembly Intracellular Protein Transport Defense Response Signal Transduction Cell Proliferation Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Of Endogenous Antigen Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of B Cell Proliferation Macrophage Migration Inhibitory Factor Signaling Pathway Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator T Cell Selection Positive Thymic T Cell Selection Negative Thymic T Cell Selection Negative Regulation Of T Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Chaperone Mediated Protein Folding Requiring Cofactor Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Neutrophil Chemotaxis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways			MHC class II antigen presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: B3GAT1 CD74 CD82 HLA-DMB HLA-DOA HLA-DRA HLA-DRB1 U2AF2	14 interactors: APP CD1D CD44 CTSF CTSL HADHA HLA-DMA HLA-DMB HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRA MIF
Entrez ID		3108	972
HPRD ID		00830	00825
Ensembl ID		ENSG00000204257	ENSG00000019582
Uniprot IDs		Q31604 Q5SP00 Q6ICR9	P04233
PDB IDs		4I0P	1A6A 1ICF 1IIE 1L3H 1MUJ 3PDO 3PGC 3PGD 3QXA 3QXD 4AEN 4AH2
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Assembly Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Regulation Of T Cell Activation Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Cell Activation Polysaccharide Assembly With MHC Class II Protein Complex Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Activation Positive Regulation Of Cell Adhesion Immune Response Regulation Of Immune System Process Positive Regulation Of Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Cellular Protein Complex Assembly Protein Complex Assembly Immune System Process Negative Regulation Of Immune System Process T Cell Costimulation Cytokine-mediated Signaling Pathway Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Macrophage Migration Inhibitory Factor Signaling Pathway Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion T Cell Receptor Signaling Pathway Negative Regulation Of Homotypic Cell-cell Adhesion Cellular Response To Cytokine Stimulus Positive Regulation Of Lymphocyte Proliferation Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Mononuclear Cell Proliferation Regulation Of T Cell Differentiation Negative Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Receptor-mediated Signaling Pathway Cellular Macromolecular Complex Assembly Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion Cellular Response To Interferon-gamma Regulation Of T Cell Proliferation Response To Cytokine Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Leukocyte Activation	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Positive Regulation Of Homotypic Cell-cell Adhesion Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Activation Immune Response Positive Regulation Of T Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Positive Regulation Of Immune Response Immune System Process Regulation Of Cell Activation Regulation Of T Cell Activation Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Cell Adhesion Interferon-gamma-mediated Signaling Pathway Cellular Response To Interferon-gamma Regulation Of Immune System Process Defense Response Response To Interferon-gamma T Cell Costimulation Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Assembly T Cell Receptor Signaling Pathway Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Antigen Receptor-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of T Cell Proliferation Immune Response-activating Cell Surface Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of T Cell Proliferation Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Cytokine Response To Organic Substance Response To Stress Response To Stimulus Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Response To Organic Substance Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Cell Proliferation
Tagcloud ?			actionable adenocarcinomas akt1 alk braf capture ccdc6 clip4 deemed driver fusions g719a genomic introns kif5b map2k1 nccn ngs nras pack pik3ca profiling rearranged ret ros1 socs5 targetable uniform v600e
Tagcloud (Difference) ?			actionable adenocarcinomas akt1 alk braf capture ccdc6 clip4 deemed driver fusions g719a genomic introns kif5b map2k1 nccn ngs nras pack pik3ca profiling rearranged ret ros1 socs5 targetable uniform v600e
Tagcloud (Intersection) ?