HLA-DMA and U2AF2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		HLA-DMA	U2AF2
Description		major histocompatibility complex, class II, DM alpha	U2 small nuclear RNA auxiliary factor 2
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GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Cell Surface Membrane Late Endosome Membrane MHC Class II Protein Complex	Commitment Complex Prp19 Complex Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck U2-type Prespliceosome U2AF Complex
	Molecular Function	Protein Binding MHC Class II Protein Complex Binding Peptide Antigen Binding	Nucleic Acid Binding RNA Binding Protein Binding Poly-pyrimidine Tract Binding Enzyme Binding Pre-mRNA 3'-splice Site Binding C2H2 Zinc Finger Domain Binding Molecular Function Inhibitor Activity
	Biological Process	Adaptive Immune Response Immune System Process Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Immune Response Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation	Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Negative Regulation Of Protein Ubiquitination Positive Regulation Of RNA Splicing Negative Regulation Of MRNA Splicing, Via Spliceosome
Pathways		MHC class II antigen presentation	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Protein hydroxylation
Drugs
Diseases		Allograft rejection
GWAS		Appendicular lean mass ( 33097823) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848)	HDL cholesterol levels ( 32203549) Menopause (age at onset) ( 26414677)
Interacting Genes		8 interacting genes: B3GAT1 CD74 CD82 HLA-DMB HLA-DOA HLA-DRA HLA-DRB1 U2AF2	71 interacting genes: - APBB1 ATXN1 BEND7 CCAR1 CDC42 CHIC2 CPSF7 DACH1 DDX6 DPPA2 DVL2 EPB41 FUBP1 GEMIN2 GLIS2 HLA-DMA HMBOX1 IL7R INO80B KHDC4 KHDRBS3 LURAP1 MAP1B MRPL15 NKAPD1 OGT OTUB2 PHF5A PIN1 POLR2A PRPF40A PUF60 QKI RBFOX2 RBM11 RBM39 RBM4 RBMY1F RBMY1J SAP30BP SCAF11 SF1 SF3B3 SF3B5 SF3B6 SMAD5 SNRPA SRPK1 SRPK2 SRSF1 SRSF11 SRSF3 STAC3 SUGP1 SUMO2 TCERG1 TCF23 THAP1 TLE5 TOP1 U2AF1 USP7 WT1 ZNF107 ZNF526 ZNF57 ZNF71 ZNF835 ZRSR2 ZRSR2P1
Entrez ID		3108	11338
HPRD ID		00830	01872
Ensembl ID		ENSG00000204257	ENSG00000063244
Uniprot IDs		P28067 Q31604 Q6ICR9	P26368
PDB IDs		1HDM 2BC4 4FQX 4GBX 4I0P	1JMT 1O0P 1OPI 1U2F 2G4B 2HZC 2M0G 2U2F 2YH0 2YH1 3VAF 3VAG 3VAH 3VAI 3VAJ 3VAK 3VAL 3VAM 4FXW 4TU7 4TU8 4TU9 5EV1 5EV2 5EV3 5EV4 5W0G 5W0H 6TR0 6XLV 6XLW 6XLX 7S3A 7S3B 7S3C 7SN6 8P25 9C7A 9C7B 9DWU
Enriched GO Terms of Interacting Partners?		MHC Class II Protein Complex MHC Class II Protein Complex Binding Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Antigen Processing And Presentation Of Exogenous Antigen Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Peptide Antigen Binding MHC Class II Receptor Activity Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Adaptive Immune Response Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Endogenous Antigen Lysosomal Membrane Lumenal Side Of Endoplasmic Reticulum Membrane Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Late Endosome Membrane Myeloid Dendritic Cell Antigen Processing And Presentation Lysosome Regulation Of T Cell Differentiation Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Transport Vesicle Membrane Regulation Of Lymphocyte Differentiation Dendritic Cell Antigen Processing And Presentation ER To Golgi Transport Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Regulation Of Cell Activation Protein-containing Complex Assembly Positive Regulation Of Immune Effector Process Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Endocytic Vesicle Membrane Positive Regulation Of Immune Response Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Autolysosome Membrane CD4 Receptor Binding Positive Regulation Of Memory T Cell Differentiation Protein-containing Complex Organization Endosome Positive Regulation Of Monocyte Differentiation Regulation Of Cell Adhesion	RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing RNA Binding RNA Metabolic Process Nucleic Acid Binding Nucleoplasm Regulation Of RNA Splicing Nucleic Acid Metabolic Process Nucleus Spliceosomal Complex Regulation Of MRNA Splicing, Via Spliceosome Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions Regulation Of MRNA Processing Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Nuclear Speck Regulation Of Nucleobase-containing Compound Metabolic Process Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Binding Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process U2AF Complex Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome U12-type Spliceosomal Complex Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Binding Positive Regulation Of Biosynthetic Process RS Domain Binding Pre-mRNA 3'-splice Site Binding Protein-containing Complex Assembly U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex MRNA Splice Site Recognition Negative Regulation Of RNA Metabolic Process Protein-containing Complex Organization Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Splicing
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