HLA-DMA and B3GAT1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		HLA-DMA	B3GAT1
Description		major histocompatibility complex, class II, DM alpha	beta-1,3-glucuronyltransferase 1
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GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Cell Surface Membrane Late Endosome Membrane MHC Class II Protein Complex	Golgi Membrane Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane
	Molecular Function	Protein Binding MHC Class II Protein Complex Binding Peptide Antigen Binding	Protein Binding Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase Activity Transferase Activity Metal Ion Binding
	Biological Process	Adaptive Immune Response Immune System Process Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Immune Response Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation	Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Protein Glycosylation Visual Learning Chondroitin Sulfate Proteoglycan Biosynthetic Process
Pathways		MHC class II antigen presentation	Glycosaminoglycan-protein linkage region biosynthesis
Drugs			D-tartaric acid Uridine-5'-Diphosphate
Diseases		Allograft rejection
GWAS		Appendicular lean mass ( 33097823) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848)	Liver enzyme levels (alkaline phosphatase) ( 33972514) N-glycan levels ( 21908519) Neonatal white matter microstructure ( 33009551) Prostate cancer ( 29892016) Schizophrenia ( 33169155) Serum alkaline phosphatase levels ( 33547301) Verbal declarative memory ( 25648963)
Interacting Genes		8 interacting genes: B3GAT1 CD74 CD82 HLA-DMB HLA-DOA HLA-DRA HLA-DRB1 U2AF2	3 interacting genes: CMTM7 HLA-DMA SH3GL1
Entrez ID		3108	27087
HPRD ID		00830	06969
Ensembl ID		ENSG00000204257	ENSG00000109956
Uniprot IDs		P28067 Q31604 Q6ICR9	Q9P2W7
PDB IDs		1HDM 2BC4 4FQX 4GBX 4I0P	1V82 1V83 1V84
Enriched GO Terms of Interacting Partners?		MHC Class II Protein Complex MHC Class II Protein Complex Binding Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Antigen Processing And Presentation Of Exogenous Antigen Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Peptide Antigen Binding MHC Class II Receptor Activity Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Adaptive Immune Response Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Endogenous Antigen Lysosomal Membrane Lumenal Side Of Endoplasmic Reticulum Membrane Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Late Endosome Membrane Myeloid Dendritic Cell Antigen Processing And Presentation Lysosome Regulation Of T Cell Differentiation Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Transport Vesicle Membrane Regulation Of Lymphocyte Differentiation Dendritic Cell Antigen Processing And Presentation ER To Golgi Transport Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Regulation Of Cell Activation Protein-containing Complex Assembly Positive Regulation Of Immune Effector Process Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Endocytic Vesicle Membrane Positive Regulation Of Immune Response Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Autolysosome Membrane CD4 Receptor Binding Positive Regulation Of Memory T Cell Differentiation Protein-containing Complex Organization Endosome Positive Regulation Of Monocyte Differentiation Regulation Of Cell Adhesion	B-1a B Cell Differentiation B-1 B Cell Differentiation
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