HLA-DMA and HLA-DOA

Number of citations of the paper that reports this interaction (PubMedID 9311912)
0

Data Source:
HPRD (in vivo)

		HLA-DMA	HLA-DOA
Description		major histocompatibility complex, class II, DM alpha	major histocompatibility complex, class II, DO alpha
Image
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Cell Surface Membrane Late Endosome Membrane MHC Class II Protein Complex	Lysosome Lysosomal Membrane Endosome Plasma Membrane Endosome Membrane Membrane Late Endosome Membrane MHC Class II Protein Complex
	Molecular Function	Protein Binding MHC Class II Protein Complex Binding Peptide Antigen Binding	Protein Binding MHC Class II Protein Complex Binding MHC Class II Receptor Activity Peptide Antigen Binding
	Biological Process	Adaptive Immune Response Immune System Process Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Immune Response Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation	Adaptive Immune Response Immune System Process Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Immune Response Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of T Cell Differentiation Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation
Pathways		MHC class II antigen presentation	MHC class II antigen presentation
Drugs
Diseases		Allograft rejection
GWAS		Appendicular lean mass ( 33097823) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848)	Asthma ( 21804548 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Chronic hepatitis B infection ( 25802187) Lung cancer ( 28604730) Mortality in sepsis ( 27639821) Periodontitis (CDC/AAP) ( 24024966) Platelet count ( 22139419) Prostate cancer ( 29892016) Red wine liking ( 25758996) Systemic lupus erythematosus ( 32771030) Wegener's granulomatosis ( 23740775) White wine liking ( 25758996)
Interacting Genes		8 interacting genes: B3GAT1 CD74 CD82 HLA-DMB HLA-DOA HLA-DRA HLA-DRB1 U2AF2	2 interacting genes: HLA-DMA REL
Entrez ID		3108	3111
HPRD ID		00830	00837
Ensembl ID		ENSG00000204257	ENSG00000204252
Uniprot IDs		P28067 Q31604 Q6ICR9	A0A1V0E3M7 A0A1V0E3N1 A0A1V0E3N3 A0A1V0E3N6 A0A1V0E3N7 A0A1V0E3P0 A0A1V0E3P1 A0A1V0E3P3 A0A1V0E3P6 A0A1V0E3P8 A0A1V0E3P9 A0A1V0E3Q1 A0A1V0E3Q2 A0A1V0E3Q3 A0A1V0E3Q4 A0A1V0E3Q5 A0A1V0E3Q6 A0A1V0E3Q7 A0A1V0E3Q8 A0A1V0E3R0 A0A1V0E3R3 A0A1V0E3R4 A0A1V0E3R6 A0A1V0E3R8 A0A1V0E3S0 A0A1V0E3S4 A0A1V0E3S6 A0A1V0E3S7 A0A1V0E3T1 P06340 X5CF87
PDB IDs		1HDM 2BC4 4FQX 4GBX 4I0P	4I0P
Enriched GO Terms of Interacting Partners?		MHC Class II Protein Complex MHC Class II Protein Complex Binding Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Antigen Processing And Presentation Of Exogenous Antigen Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Peptide Antigen Binding MHC Class II Receptor Activity Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Adaptive Immune Response Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Endogenous Antigen Lysosomal Membrane Lumenal Side Of Endoplasmic Reticulum Membrane Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Late Endosome Membrane Myeloid Dendritic Cell Antigen Processing And Presentation Lysosome Regulation Of T Cell Differentiation Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Transport Vesicle Membrane Regulation Of Lymphocyte Differentiation Dendritic Cell Antigen Processing And Presentation ER To Golgi Transport Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Regulation Of Cell Activation Protein-containing Complex Assembly Positive Regulation Of Immune Effector Process Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Endocytic Vesicle Membrane Positive Regulation Of Immune Response Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Autolysosome Membrane CD4 Receptor Binding Positive Regulation Of Memory T Cell Differentiation Protein-containing Complex Organization Endosome Positive Regulation Of Monocyte Differentiation Regulation Of Cell Adhesion	MHC Class II Protein Complex MHC Class II Protein Complex Binding Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Peptide Antigen Binding Antigen Processing And Presentation Of Exogenous Peptide Antigen Peptide Antigen Assembly With MHC Class II Protein Complex Negative Regulation Of Interferon-beta Production Non-canonical NF-kappaB Signal Transduction NF-kappaB Complex
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