HK2 and UBQLN4

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HK2	UBQLN4
Gene Name		hexokinase 2	ubiquilin 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrial Outer Membrane Cytosol Membrane	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Nuclear Proteasome Complex Cytosolic Proteasome Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Glucokinase Activity Hexokinase Activity ATP Binding Glucose Binding Fructokinase Activity Mannokinase Activity	Protein Binding Polyubiquitin Binding Identical Protein Binding
	Biological Process	Cellular Glucose Homeostasis Response To Ischemia Carbohydrate Metabolic Process Glucose Metabolic Process Glycolytic Process Lactation Apoptotic Mitochondrial Changes Hexose Transport Pathogenesis Glucose Transport Small Molecule Metabolic Process Regulation Of Glucose Import Carbohydrate Phosphorylation Glucose 6-phosphate Metabolic Process Transmembrane Transport	Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pathways		Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates Glucose transport SLC-mediated transmembrane transport Hexose transport
Drugs
Diseases
GWAS		Femoral neck bone geometry ( 22087292)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		7 interactors: MAGEA12 PRKCE PTGDS SLC2A4 UBQLN1 UBQLN4 ZBTB17	157 interactors: ADAM33 ADPGK AGR2 ANKRD13D AREG ARL4C ATPIF1 ATXN1 BAG6 BPIFA1 C11orf49 C1orf94 C1QTNF1 CACNA1G CCDC107 CCDC134 CCDC136 CCDC14 CCDC33 CCL21 CD99 CDSN CEND1 COL8A1 COPB1 CPSF6 CRIPT CSTF2 CSTF2T CTSB CYB5R1 DAZAP2 DKK3 DMPK DNAJB11 DTX2 EAPP EDN1 EEF1A1 EFEMP2 ELF5 EPDR1 ERP27 ERP29 FA2H FGFBP1 FKBP2 FKBP7 FZD7 GABRD GDI1 GKAP1 GPX7 HAVCR1 HGS HK2 HSPA13 HSPA5 IGFBP6 IGHM IGLC1 IMMT IMPDH2 ITPRIPL1 KLHL26 KLHL42 LAT2 MDK MDM2 MIEF2 MIF4GD MLLT6 MOAP1 MYDGF NAE1 NME3 NOMO1 NOMO3 NOTCH2NL NPHP1 NPPA NXF1 OAT ORC5 PBXIP1 PCDH17 PCDH8 PDIA5 PDLIM7 PELI2 PICK1 PIN1 PIP4K2B PLA2G16 PMEPA1 PNMA1 PPIB PPIC PRL PRPF40A PSMD4 PTN PTPRN PTPRN2 QSOX1 RAD23A RAI2 RBM10 RIC8A RNF11 RNPS1 ROBO2 RPN1 RSRC2 RUNX1T1 RXRA SCAF1 SCG2 SCG5 SCMH1 SEMG1 SERPINE1 SERPINH1 SERPINI2 SMAD3 SMAD9 SMARCB1 SPAG8 SPINT1 SPP1 SRGN SRSF2 STAM2 STMN1 SUPT20H TFF1 TGFB1I1 TNFRSF14 TNRC6B TRAF2 TRIB2 TRIM32 UBQLN1 UBQLN2 UBR7 UNC119 UROS USMG5 VIP WAC YWHAQ ZBTB22 ZDHHC3 ZFPM2 ZG16 ZG16B ZNF205
Entrez ID		3099	56893
HPRD ID		03080	05670
Ensembl ID		ENSG00000159399	ENSG00000160803
Uniprot IDs		P52789	B4DZF6 Q9NRR5
PDB IDs		2NZT
Enriched GO Terms of Interacting Partners?		Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Response To Hypoxia Positive Regulation Of Cellular Glucuronidation Amylopectin Biosynthetic Process Cellular Response To Stress TRAM-dependent Toll-like Receptor 4 Signaling Pathway Response To Ethanol Response To Endoplasmic Reticulum Stress Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Negative Regulation Of Sodium Ion Transmembrane Transport Regulation Of Protein Metabolic Process Cellular Response To Ethanol Glucose Import Response To Abiotic Stimulus Positive Regulation Of Fibroblast Migration Macrophage Activation Involved In Immune Response Locomotory Exploration Behavior Response To Organic Substance Negative Regulation Of Sodium Ion Transport	Regulation Of Cellular Process Response To Stress Positive Regulation Of Cellular Metabolic Process Response To Stimulus Signaling Signal Transduction Cell Communication Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Multicellular Organismal Development Positive Regulation Of Metabolic Process Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Cell Proliferation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transport Organ Development Positive Regulation Of Mitochondrion Organization Regulation Of Cellular Localization Regulation Of Proteolysis Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Developmental Process Response To Organic Substance Tissue Development Regulation Of Metabolic Process Positive Regulation Of Gene Expression Anatomical Structure Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Behavior Regulation Of Phosphorus Metabolic Process System Development Protein Peptidyl-prolyl Isomerization Regulation Of Signaling Negative Regulation Of Cell Proliferation Regulation Of Body Fluid Levels Regulation Of Chemotaxis Cell Surface Receptor Signaling Pathway Regulation Of Phosphorylation Cellular Localization Defense Response Regulation Of Mitochondrion Organization Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cellular Component Organization
Tagcloud ?		acly anabolism bioenergetic bioenergetics chemoresistance clarified clearer complexified concepts dialog dysfunctional facets flexibility glutamine ldha likewise microenvironmental modulators mycn oncometabolites owing pgam1 progressed proof remodel stroma symbiosis translated warburg
Tagcloud (Difference) ?		acly anabolism bioenergetic bioenergetics chemoresistance clarified clearer complexified concepts dialog dysfunctional facets flexibility glutamine ldha likewise microenvironmental modulators mycn oncometabolites owing pgam1 progressed proof remodel stroma symbiosis translated warburg
Tagcloud (Intersection) ?