HK2 and UBQLN4

Number of citations of the paper that reports this interaction (PubMedID 16713569)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HK2	UBQLN4
Description		hexokinase 2	ubiquilin 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Centrosome Cytosol Membrane Sarcoplasmic Reticulum	Nucleus Nucleoplasm Chromosome Cytoplasm Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Cytoplasmic Vesicle Nuclear Proteasome Complex Cytosolic Proteasome Complex Protein-containing Complex Perinuclear Region Of Cytoplasm Site Of DNA Damage
	Molecular Function	Nucleotide Binding Catalytic Activity Glucokinase Activity Hexokinase Activity Protein Binding ATP Binding D-glucose Binding Fructokinase Activity Kinase Activity Transferase Activity Phosphotransferase Activity, Alcohol Group As Acceptor	Protein Binding Polyubiquitin Modification-dependent Protein Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding
	Biological Process	Response To Hypoxia Intracellular Glucose Homeostasis Response To Ischemia Carbohydrate Metabolic Process Fructose 6-phosphate Metabolic Process Glucose Metabolic Process Glycolytic Process Lactation Apoptotic Mitochondrial Changes Hexose Metabolic Process Organophosphate Metabolic Process Negative Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Angiogenesis Regulation Of D-glucose Import Carbohydrate Phosphorylation Glucose 6-phosphate Metabolic Process Canonical Glycolysis Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion Carbohydrate Derivative Metabolic Process Positive Regulation Of Type 2 Mitophagy Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Reactive Oxygen Species Metabolic Process	DNA Repair Ubiquitin-dependent Protein Catabolic Process Autophagy DNA Damage Response Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Response To Stress Negative Regulation Of Autophagosome Maturation Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Glycolysis
Drugs
Diseases
GWAS		Femoral neck bone geometry ( 22087292)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 29273807) Crohn's disease ( 28067908) General risk tolerance (MTAG) ( 30643258) Inflammatory bowel disease ( 23128233 28067908)
Interacting Genes		10 interacting genes: ENO1 MAGEA12 PRKCE PROM1 PTGDS SLC2A4 SUMO2 UBQLN1 UBQLN4 ZBTB17	163 interacting genes: ADAM33 ADPGK AGR2 ANKRD13D AREG ARL4C ATP5IF1 ATP5MK ATXN1 BAG6 BPIFA1 C1orf94 C1QTNF1 CACNA1G CCDC107 CCDC134 CCDC136 CCDC14 CCDC33 CCL21 CD274 CD99 CDSN CEND1 COL8A1 COPB1 CPSF6 CRIPT CSTF2 CSTF2T CSTPP1 CTSB CYB5R1 DAZAP2 DKK3 DMPK DNAJB11 DTX2 EAPP EDN1 EEF1A1 EFEMP2 ELF5 EPDR1 ERP27 ERP29 FA2H FGFBP1 FKBP2 FKBP7 FZD7 GABRD GDI1 GJA1 GJA5 GJC1 GKAP1 GPX7 HAVCR1 HGS HK2 HSPA13 HSPA5 IGFBP6 IGHM IGLC1 IMMT IMPDH2 ITPRIPL1 KLHL26 KLHL42 LAT2 MDK MDM2 MIEF2 MIF4GD MLLT6 MOAP1 MTNR1B MYDGF NAE1 NME3 NOMO1 NOMO3 NOTCH2NLA NPHP1 NPPA NXF1 OAT ORC5 PBXIP1 PCDH17 PCDH8 PDIA5 PDLIM7 PELI2 PICK1 PIN1 PIP4K2B PLAAT3 PMEPA1 PNMA1 PPIB PPIC PRL PRPF40A PTN PTPRN PTPRN2 QSOX1 RAD23A RAI2 RBM10 RIC8A RNF11 RNPS1 ROBO2 RPN1 RSRC2 RUNX1T1 RXRA SCAF1 SCG2 SCG5 SCMH1 SEMG1 SERPINE1 SERPINH1 SERPINI2 SMAD3 SMAD9 SMARCB1 SPAG8 SPINT1 SPP1 SRGN SRSF2 STAM2 STMN1 SUPT20H TFF1 TGFB1I1 TNFRSF14 TNRC6B TRAF2 TRIB2 TRIM32 UBC UBQLN1 UBQLN2 UBR7 UNC119 UROS VIP WAC WWP2 YWHAQ ZBTB22 ZDHHC3 ZFPM2 ZG16 ZG16B ZNF205
Entrez ID		3099	56893
HPRD ID		03080	05670
Ensembl ID		ENSG00000159399	ENSG00000160803
Uniprot IDs		E9PB90 P52789	B4DZF6 Q59F94 Q9NRR5
PDB IDs		2NZT 5HEX 5HFU 5HG1
Enriched GO Terms of Interacting Partners?		Regulation Of Proteolysis Cellular Response To Decreased Oxygen Levels Cellular Response To Hypoxia Perinuclear Region Of Cytoplasm Cellular Response To Oxygen Levels Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Response To Hypoxia Amylopectin Biosynthetic Process D-glucose Uniporter Activity Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Negative Regulation Of Store-operated Calcium Channel Activity Response To Decreased Oxygen Levels Regulation Of Protein Metabolic Process Response To Oxygen Levels Endoplasmic Reticulum Negative Regulation Of Cation Transmembrane Transport Ethanol Binding Negative Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Prominosome Glomerular Parietal Epithelial Cell Differentiation Autophagosome Nuclear Proteasome Complex Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity Negative Regulation Of Monoatomic Ion Transport TRAM-dependent Toll-like Receptor 4 Signaling Pathway Prostaglandin-D Synthase Activity Negative Regulation Of Male Germ Cell Proliferation Positive Regulation Of Nephron Tubule Epithelial Cell Differentiation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Autophagosome Maturation Negative Regulation Of Transmembrane Transport Positive Regulation Of Proteasomal Protein Catabolic Process Response To Ethanol Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Toxin Catabolic Process White Fat Cell Proliferation Positive Regulation Of Mucus Secretion Regulation Of Male Germ Cell Proliferation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cytosolic Proteasome Complex Regulation Of Cellular Response To Stress Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Catabolic Process Regulation Of Germ Cell Proliferation	Protein Binding Endoplasmic Reticulum Lumen Extracellular Region Regulation Of Transport SA Node Cell To Atrial Cardiac Muscle Cell Communication Protein Folding Extracellular Space Peptidyl-prolyl Cis-trans Isomerase Activity Positive Regulation Of Metabolic Process Regulation Of Cell Communication Cardiac Muscle Tissue Development AV Node Cell To Bundle Of His Cell Communication Positive Regulation Of Proteolysis Protein Disulfide Isomerase Activity Gap Junction Assembly Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cell Communication Involved In Cardiac Conduction Regulation Of Protein Catabolic Process Regulation Of Signaling Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Gap Junction Channel Activity Involved In SA Node Cell-atrial Cardiac Muscle Cell Electrical Coupling SA Node Cell To Atrial Cardiac Muscle Cell Communication By Electrical Coupling Regulation Of Macroautophagy Endoplasmic Reticulum Chaperone Complex Positive Regulation Of Cell Communication Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Negative Regulation Of Fat Cell Differentiation Tissue Development Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Neutrophil Migration Negative Regulation Of Cell Population Proliferation Endoplasmic Reticulum Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Epithelial Cell Proliferation Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Regulation Of Response To Endoplasmic Reticulum Stress ESCRT-0 Complex Positive Regulation Of Protein Metabolic Process Regulation Of Biological Quality Regulation Of Membrane Potential Positive Regulation Of Catabolic Process Regulation Of Proteolysis Positive Regulation Of Macroautophagy Collagen Binding Establishment Of Protein Localization MRNA Cleavage And Polyadenylation Specificity Factor Complex Peptidase Inhibitor Complex
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