HK2 and SLC2A4

Number of citations of the paper that reports this interaction (PMID 16396496)
24

Data Source:
HPRD (in vivo)

		HK2	SLC2A4
Gene Name		hexokinase 2	solute carrier family 2 (facilitated glucose transporter), member 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrial Outer Membrane Cytosol Membrane	Multivesicular Body Cytosol Plasma Membrane Integral Component Of Plasma Membrane Coated Pit External Side Of Plasma Membrane Endomembrane System Vesicle Membrane Membrane Clathrin-coated Vesicle Trans-Golgi Network Transport Vesicle T-tubule Insulin-responsive Compartment Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Glucokinase Activity Hexokinase Activity ATP Binding Glucose Binding Fructokinase Activity Mannokinase Activity	Glucose Transmembrane Transporter Activity Protein Binding D-glucose Transmembrane Transporter Activity
	Biological Process	Cellular Glucose Homeostasis Response To Ischemia Carbohydrate Metabolic Process Glucose Metabolic Process Glycolytic Process Lactation Apoptotic Mitochondrial Changes Hexose Transport Pathogenesis Glucose Transport Small Molecule Metabolic Process Regulation Of Glucose Import Carbohydrate Phosphorylation Glucose 6-phosphate Metabolic Process Transmembrane Transport	Carbohydrate Metabolic Process Hexose Transport Pathogenesis Amylopectin Biosynthetic Process Glucose Transport Cellular Response To Insulin Stimulus Glucose Homeostasis Small Molecule Metabolic Process Response To Ethanol Glucose Import Brown Fat Cell Differentiation Transmembrane Transport Membrane Organization Cellular Response To Hypoxia Cellular Response To Osmotic Stress
Pathways		Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates Glucose transport SLC-mediated transmembrane transport Hexose transport	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds Translocation of GLUT4 to the plasma membrane SLC-mediated transmembrane transport Hexose transport Myoclonic epilepsy of Lafora Transcriptional regulation of white adipocyte differentiation Facilitative Na+-independent glucose transporters Glycogen storage diseases Glucose transport Metabolism of carbohydrates
Drugs
Diseases
GWAS		Femoral neck bone geometry ( 22087292)	Birth weight ( 23202124) Metabolite levels ( 22286219)
Protein-Protein Interactions		7 interactors: MAGEA12 PRKCE PTGDS SLC2A4 UBQLN1 UBQLN4 ZBTB17	38 interactors: ACOX1 ACTN1 ACTN4 AKT2 ARF3 ARFIP1 BSG C1QTNF5 CCDC116 CFL1 CTSD DAXX DLD EHD2 ESYT2 FAR1 FKBP10 GAPDH HADH HK2 HSP90AA1 IDH2 KLHL41 LNPEP MAP1S MVP P3H1 P3H4 PDIA6 PRKAR1A PSMD7 RAB7A SERPINH1 SRFBP1 STRN3 UBA52 UBE2I UBE2N
Entrez ID		3099	6517
HPRD ID		03080	00688
Ensembl ID		ENSG00000159399	ENSG00000181856
Uniprot IDs		P52789	P14672 Q05BQ3
PDB IDs		2NZT
Enriched GO Terms of Interacting Partners?		Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Response To Hypoxia Positive Regulation Of Cellular Glucuronidation Amylopectin Biosynthetic Process Cellular Response To Stress TRAM-dependent Toll-like Receptor 4 Signaling Pathway Response To Ethanol Response To Endoplasmic Reticulum Stress Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Negative Regulation Of Sodium Ion Transmembrane Transport Regulation Of Protein Metabolic Process Cellular Response To Ethanol Glucose Import Response To Abiotic Stimulus Positive Regulation Of Fibroblast Migration Macrophage Activation Involved In Immune Response Locomotory Exploration Behavior Response To Organic Substance Negative Regulation Of Sodium Ion Transport	Generation Of Precursor Metabolites And Energy Catabolic Process Protein Localization To Tight Junction Protein Transport Establishment Of Protein Localization Protein Localization Small Molecule Metabolic Process Organelle Organization Positive Regulation Of Transferase Activity Monocarboxylic Acid Metabolic Process Regulation Of Body Fluid Levels Antigen Processing And Presentation Of Peptide Antigen Protein Targeting Blood Coagulation Hemostasis Pyruvate Metabolic Process Intracellular Protein Transport Oxidation-reduction Process Response To Stress Protein Localization To Cell Junction Glucose Metabolic Process Antigen Processing And Presentation Regulation Of Cellular Protein Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Establishment Of Localization In Cell Protein Polyubiquitination Response To Stimulus Cellular Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Cytoskeleton Organization Protein Localization To Membrane Platelet Degranulation Immune System Process Vesicle-mediated Transport Protein Ubiquitination Regulation Of Protein Metabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Extracellular Matrix Organization Extracellular Structure Organization Collagen Metabolic Process Membrane Organization Actin Cytoskeleton Organization Positive Regulation Of Ligase Activity Intracellular Receptor Signaling Pathway Transport Wound Healing Multicellular Organismal Macromolecule Metabolic Process Protein Metabolic Process Regulation Of Protein Ubiquitination
Tagcloud ?		acly anabolism bioenergetic bioenergetics chemoresistance clarified clearer complexified concepts dialog dysfunctional facets flexibility glutamine ldha likewise microenvironmental modulators mycn oncometabolites owing pgam1 progressed proof remodel stroma symbiosis translated warburg	atp1a2 atp1b2 beef corpus cows diestrus follicle glandular gonadotropin lcl lf luteum manipulated nelore ovulation p4 periovulatory pof preovulatory proestrus receptivity slaughtered slc5a1 washings
Tagcloud (Difference) ?		acly anabolism bioenergetic bioenergetics chemoresistance clarified clearer complexified concepts dialog dysfunctional facets flexibility glutamine ldha likewise microenvironmental modulators mycn oncometabolites owing pgam1 progressed proof remodel stroma symbiosis translated warburg	atp1a2 atp1b2 beef corpus cows diestrus follicle glandular gonadotropin lcl lf luteum manipulated nelore ovulation p4 periovulatory pof preovulatory proestrus receptivity slaughtered slc5a1 washings
Tagcloud (Intersection) ?