HK2 and ZBTB17

Number of citations of the paper that reports this interaction (PubMedID 11068878)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		HK2	ZBTB17
Description		hexokinase 2	zinc finger and BTB domain containing 17
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Centrosome Cytosol Membrane Sarcoplasmic Reticulum	Nucleus Nucleoplasm Protein-containing Complex Protein-DNA Complex
	Molecular Function	Nucleotide Binding Catalytic Activity Glucokinase Activity Hexokinase Activity Protein Binding ATP Binding D-glucose Binding Fructokinase Activity Kinase Activity Transferase Activity Phosphotransferase Activity, Alcohol Group As Acceptor	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Core Promoter Sequence-specific DNA Binding Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding DNA-binding Transcription Factor Binding
	Biological Process	Response To Hypoxia Intracellular Glucose Homeostasis Response To Ischemia Carbohydrate Metabolic Process Fructose 6-phosphate Metabolic Process Glucose Metabolic Process Glycolytic Process Lactation Apoptotic Mitochondrial Changes Hexose Metabolic Process Organophosphate Metabolic Process Negative Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Angiogenesis Regulation Of D-glucose Import Carbohydrate Phosphorylation Glucose 6-phosphate Metabolic Process Canonical Glycolysis Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion Carbohydrate Derivative Metabolic Process Positive Regulation Of Type 2 Mitophagy Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Reactive Oxygen Species Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Gastrulation With Mouth Forming Second Regulation Of Cytokine Production Regulation Of Immune System Process Ectoderm Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II G1 To G0 Transition
Pathways		Glycolysis	XBP1(S) activates chaperone genes
Drugs
Diseases
GWAS		Femoral neck bone geometry ( 22087292)	Dilated cardiomyopathy ( 33495596) Dilated cardiomyopathy (MTAG) ( 33495596) Erectile dysfunction ( 30583798) Glomerular filtration rate ( 29403010) Heel bone mineral density ( 30598549) Idiopathic dilated cardiomyopathy ( 21459883)
Interacting Genes		10 interacting genes: ENO1 MAGEA12 PRKCE PROM1 PTGDS SLC2A4 SUMO2 UBQLN1 UBQLN4 ZBTB17	28 interacting genes: BCL6 CDKN2B CREBBP DIS3 DNMT3A E2F6 EP300 ESR1 ESR2 GTF2I HCFC1 HK2 HK3 HSPB1 IRF8 ITGB5 MAX MSX2 MYC MYCN PGR TMPRSS11A TOPBP1 TRIM55 TRIM63 VHL ZBTB7C ZBTB8A
Entrez ID		3099	7709
HPRD ID		03080	04968
Ensembl ID		ENSG00000159399	ENSG00000116809
Uniprot IDs		E9PB90 P52789	Q13105 Q53EM1
PDB IDs		2NZT 5HEX 5HFU 5HG1	2LVR 2LVT 2LVU 2M0D 2M0E 2M0F 2N25 2N26 2Q81 3M52 4U2M 4U2N 5ION 7AZW 7AZX 7MC1 7MC2 7MC3 7T58
Enriched GO Terms of Interacting Partners?		Regulation Of Proteolysis Cellular Response To Decreased Oxygen Levels Cellular Response To Hypoxia Perinuclear Region Of Cytoplasm Cellular Response To Oxygen Levels Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Response To Hypoxia Amylopectin Biosynthetic Process D-glucose Uniporter Activity Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Negative Regulation Of Store-operated Calcium Channel Activity Response To Decreased Oxygen Levels Regulation Of Protein Metabolic Process Response To Oxygen Levels Endoplasmic Reticulum Negative Regulation Of Cation Transmembrane Transport Ethanol Binding Negative Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Prominosome Glomerular Parietal Epithelial Cell Differentiation Autophagosome Nuclear Proteasome Complex Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity Negative Regulation Of Monoatomic Ion Transport TRAM-dependent Toll-like Receptor 4 Signaling Pathway Prostaglandin-D Synthase Activity Negative Regulation Of Male Germ Cell Proliferation Positive Regulation Of Nephron Tubule Epithelial Cell Differentiation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Autophagosome Maturation Negative Regulation Of Transmembrane Transport Positive Regulation Of Proteasomal Protein Catabolic Process Response To Ethanol Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Toxin Catabolic Process White Fat Cell Proliferation Positive Regulation Of Mucus Secretion Regulation Of Male Germ Cell Proliferation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cytosolic Proteasome Complex Regulation Of Cellular Response To Stress Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Catabolic Process Regulation Of Germ Cell Proliferation	Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Transcription Coactivator Binding Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Chromatin Organization DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Estrogen Response Element Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Response To Decreased Oxygen Levels Chromatin Chromatin Remodeling Regulation Of Gene Expression Response To Oxygen Levels Regulation Of Macromolecule Biosynthetic Process Histone H3K27 Acetyltransferase Activity Myc-Max Complex Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nuclear Steroid Receptor Activity Morphogenesis Of A Branching Structure Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Histone Acetyltransferase Complex Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?