ISG15 and UBA7

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (in vivo, two hybrid)

		ISG15	UBA7
Gene Name		ISG15 ubiquitin-like modifier	ubiquitin-like modifier activating enzyme 7
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytosol	Nucleus Cytosol
	Molecular Function	Protein Binding Protein Tag	Ubiquitin Activating Enzyme Activity Ubiquitin-protein Transferase Activity ATP Binding ISG15 Activating Enzyme Activity
	Biological Process	Viral Process Cytokine-mediated Signaling Pathway Modification-dependent Protein Catabolic Process Negative Regulation Of Protein Ubiquitination ISG15-protein Conjugation Negative Regulation Of Type I Interferon Production Regulation Of Interferon-gamma Production Response To Type I Interferon Defense Response To Bacterium Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Erythrocyte Differentiation Defense Response To Virus Type I Interferon Signaling Pathway	Cellular Protein Modification Process Protein Ubiquitination Cytokine-mediated Signaling Pathway Modification-dependent Protein Catabolic Process ISG15-protein Conjugation Negative Regulation Of Type I Interferon Production Innate Immune Response
Pathways		RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling Antiviral mechanism by IFN-stimulated genes Innate Immune System	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Antigen processing: Ubiquitination & Proteasome degradation Negative regulators of RIG-I/MDA5 signaling ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Class I MHC mediated antigen processing & presentation Antiviral mechanism by IFN-stimulated genes Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS			Ulcerative colitis ( 21297633)
Protein-Protein Interactions		4 interactors: UBA7 UBE2E2 USP18 USP21	4 interactors: FAS ISG15 UBE2L3 UBE2L6
Entrez ID		9636	7318
HPRD ID		00958	01873
Ensembl ID		ENSG00000187608	ENSG00000182179
Uniprot IDs		P05161	P41226
PDB IDs		1Z2M 2HJ8 3PHX 3PSE 3R66 3RT3 3SDL
Enriched GO Terms of Interacting Partners?		ISG15-protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Protein Deubiquitination Protein Modification By Small Protein Removal Cellular Macromolecule Catabolic Process Cellular Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Cellular Protein Metabolic Process Regulation Of Protein Catabolic Process Catabolic Process Cytokine-mediated Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Deubiquitination Protein K63-linked Deubiquitination Protein Metabolic Process Histone Deubiquitination Protein Ubiquitination Cellular Response To Cytokine Stimulus Protein K11-linked Ubiquitination Protein Modification By Small Protein Conjugation Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Proteolysis Response To Cytokine Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Innate Immune Response Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Type I Interferon Production Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Response To Stress Regulation Of Cytokine-mediated Signaling Pathway Immune Response Defense Response Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Regulation Of Type I Interferon Production Response To Type I Interferon Positive Regulation Of Mitotic Cell Cycle	ISG15-protein Conjugation Negative Regulation Of Type I Interferon Production Modification-dependent Protein Catabolic Process Cellular Response To Organic Substance Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Response To Cytokine Stimulus Protein Catabolic Process Response To Cytokine Regulation Of Type I Interferon Production Response To Organic Substance Cellular Macromolecule Catabolic Process Response To Glucocorticoid Response To Corticosteroid Motor Neuron Apoptotic Process Regulation Of Myeloid Cell Differentiation Regulation Of Protein Ubiquitination Negative Regulation Of Cytokine Production Immune Response Necroptotic Signaling Pathway Proteolysis Transformed Cell Apoptotic Process Activation-induced Cell Death Of T Cells Inflammatory Cell Apoptotic Process Cellular Response To Hyperoxia Positive Regulation Of Protein Homooligomerization Catabolic Process Pantothenate Metabolic Process Cytokine-mediated Signaling Pathway Regulation Of Cellular Protein Metabolic Process Response To Steroid Hormone Negative Thymic T Cell Selection Negative T Cell Selection Long-chain Fatty-acyl-CoA Biosynthetic Process Immune System Process Cellular Response To Lithium Ion T Cell Apoptotic Process Regulation Of Protein Metabolic Process Regulation Of Cytokine Production Protein Metabolic Process Fatty-acyl-CoA Biosynthetic Process Positive Regulation Of Protein Oligomerization Hepatocyte Apoptotic Process Protein Ubiquitination Positive Regulation Of Erythrocyte Differentiation Protein K11-linked Ubiquitination Thymic T Cell Selection Acetyl-CoA Metabolic Process Long-chain Fatty-acyl-CoA Metabolic Process Protein Modification By Small Protein Conjugation
Tagcloud ?		arborization asparate blocking branching cns corroborate dendritic dysfunction engagement evident extend glun2a glun2b hand ifnalpha ifnar indicators indirect initially interferon ko neurocognitive neuroinflammation neurotoxic neurotoxicity nmdar partially protect stat1
Tagcloud (Difference) ?		arborization asparate blocking branching cns corroborate dendritic dysfunction engagement evident extend glun2a glun2b hand ifnalpha ifnar indicators indirect initially interferon ko neurocognitive neuroinflammation neurotoxic neurotoxicity nmdar partially protect stat1
Tagcloud (Intersection) ?