ISG15 and MRTO4

Number of citations of the paper that reports this interaction (PubMedID 34599178)
110

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ISG15	MRTO4
Description		ISG15 ubiquitin like modifier	MRT4 homolog, ribosome maturation factor
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GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleolus Cytoplasm Preribosome, Large Subunit Precursor
	Molecular Function	Integrin Binding Protein Binding Protein Tag Activity Ubiquitin Protein Ligase Binding	RNA Binding Protein Binding
	Biological Process	Immune System Process Regulation Of Immune System Process Integrin-mediated Signaling Pathway Response To Virus Response To Bacterium Protein Ubiquitination Modification-dependent Protein Catabolic Process Positive Regulation Of Bone Mineralization Negative Regulation Of Protein Ubiquitination ISG15-protein Conjugation Positive Regulation Of Protein Oligomerization Regulation Of Type II Interferon Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-10 Production Response To Type I Interferon Defense Response To Bacterium Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Multicellular Organismal Process Defense Response To Virus Negative Regulation Of Type I Interferon-mediated Signaling Pathway Protein Localization To Mitochondrion	Ribosomal Large Subunit Assembly Nuclear-transcribed MRNA Catabolic Process RRNA Processing Ribosome Biogenesis Ribosomal Large Subunit Biogenesis
Pathways		ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Interferon alpha/beta signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses RSV-host interactions PKR-mediated signaling Modulation of host responses by IFN-stimulated genes
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Cerebrospinal AB1-42 levels in normal cognition ( 29274321)
Interacting Genes		25 interacting genes: BRAP CBX5 DDOST FUS GRPEL1 HDAC6 HIF1A KLHL26 MRTO4 NAP1L1 NCL PFN1 RPL23 RPL3 RPN2 SUMO1 TPM3 TPM4 TUBA1B UBA7 USP14 USP16 USP18 USP21 USP5	4 interacting genes: CEBPA DNAJB6 ISG15 TERF2IP
Entrez ID		9636	51154
HPRD ID		00958	12725
Ensembl ID		ENSG00000187608	ENSG00000053372
Uniprot IDs		P05161	Q9UKD2
PDB IDs		1Z2M 2HJ8 3PHX 3PSE 3R66 3RT3 3SDL 5TL6 5W8T 5W8U 6BI8 6FFA 6XA9 7RBS 7S6P 8OIF 8SE9 8SEA 8SEB 8SV8	8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8IDT 8IDY 8IE3 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8RL2
Enriched GO Terms of Interacting Partners?		Cysteine-type Deubiquitinase Activity Protein Deubiquitination Regulation Of Protein Stability Protein Modification By Small Protein Removal Cysteine-type Peptidase Activity Protein Metabolic Process Post-translational Protein Modification Protein Modification Process Presynaptic Cytosol Muscle Thin Filament Tropomyosin Oligosaccharyltransferase Complex B Macromolecule Metabolic Process Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Proteolysis Ubiquitin Protein Ligase Binding Oligosaccharyltransferase Complex A Cytoplasm Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Cysteine-type Endopeptidase Activity Regulation Of Epithelial Cell Migration Oligosaccharyltransferase Complex Negative Regulation Of Catabolic Process Axonal Transport Of Mitochondrion Adenyl-nucleotide Exchange Factor Activity Regulation Of Proteolysis Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Nucleolus Peptidase Activity Ubiquitin Binding Cellular Response To Interleukin-4 Deubiquitinase Activity Protein K48-linked Deubiquitination Mitochondrion Transport Along Microtubule Response To Interleukin-4 Postsynaptic Cytosol Histone Deacetylase Binding Response To Cytokine RNA Binding Regulation Of Protein Metabolic Process Establishment Of Mitochondrion Localization Response To Peptide Proteolysis Positive Regulation Of Gene Expression Negative Regulation Of Protein Metabolic Process ISG15 Activating Enzyme Activity Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Positive Regulation Of Ribosome Biogenesis Hsp90 Protein Binding	CHOP-C/EBP Complex Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Protein Localization To Organelle Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Chorion Development Negative Regulation Of DNA Recombination At Telomere White Fat Cell Proliferation Positive Regulation Of Protein Oligomerization Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex ISG15-protein Conjugation Shelterin Complex Response To Phenylpropanoid Chorio-allantoic Fusion Protection From Non-homologous End Joining At Telomere Negative Regulation Of Nucleobase-containing Compound Metabolic Process Urea Metabolic Process Nucleoplasm HMG Box Domain Binding Urea Cycle STAT Family Protein Binding Regulation Of Protein Metabolic Process Fat Cell Proliferation Response To Type I Interferon Negative Regulation Of Inclusion Body Assembly Protein Localization To Chromosome, Telomeric Region Nuclear Telomere Cap Complex Telomere Capping G-rich Strand Telomeric DNA Binding Response To Lithium Ion Transcription By RNA Polymerase I Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Interleukin-6-mediated Signaling Pathway Regulation Of Hemopoiesis Osteoblast Development Intracellular Protein Localization Protein Tag Activity Regulation Of Cellular Response To Heat Telomere Maintenance In Response To DNA Damage Brown Fat Cell Differentiation Granulocyte Differentiation Positive Regulation Of Macrophage Activation Response To Peptide
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