ISG15 and DDOST

Number of citations of the paper that reports this interaction (PubMedID 34599178)
110

Data Source:
BioGRID (pull down)

		ISG15	DDOST
Description		ISG15 ubiquitin like modifier	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit
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GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Oligosaccharyltransferase Complex Membrane Azurophil Granule Membrane Intracellular Membrane-bounded Organelle Oligosaccharyltransferase Complex A Oligosaccharyltransferase Complex B
	Molecular Function	Integrin Binding Protein Binding Protein Tag Activity Ubiquitin Protein Ligase Binding	Protein Binding Enzyme Activator Activity
	Biological Process	Immune System Process Regulation Of Immune System Process Integrin-mediated Signaling Pathway Response To Virus Response To Bacterium Protein Ubiquitination Modification-dependent Protein Catabolic Process Positive Regulation Of Bone Mineralization Negative Regulation Of Protein Ubiquitination ISG15-protein Conjugation Positive Regulation Of Protein Oligomerization Regulation Of Type II Interferon Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-10 Production Response To Type I Interferon Defense Response To Bacterium Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Multicellular Organismal Process Defense Response To Virus Negative Regulation Of Type I Interferon-mediated Signaling Pathway Protein Localization To Mitochondrion	Protein Glycosylation Protein N-linked Glycosylation Protein N-linked Glycosylation Via Asparagine Regulation Of Protein Stability Response To Cytokine T Cell Activation
Pathways		ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Interferon alpha/beta signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses RSV-host interactions PKR-mediated signaling Modulation of host responses by IFN-stimulated genes	SRP-dependent cotranslational protein targeting to membrane Asparagine N-linked glycosylation Neutrophil degranulation Advanced glycosylation endproduct receptor signaling Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane PD-L1(CD274) glycosylation and translocation to plasma membrane
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Proportion of activated microglia (inferior temporal cortex) ( 30679421)
Interacting Genes		25 interacting genes: BRAP CBX5 DDOST FUS GRPEL1 HDAC6 HIF1A KLHL26 MRTO4 NAP1L1 NCL PFN1 RPL23 RPL3 RPN2 SUMO1 TPM3 TPM4 TUBA1B UBA7 USP14 USP16 USP18 USP21 USP5	7 interacting genes: ISG15 LTB4R2 MAPK6 NXT1 PTEN SRSF11 STING1
Entrez ID		9636	1650
HPRD ID		00958	03728
Ensembl ID		ENSG00000187608	ENSG00000244038
Uniprot IDs		P05161	P39656
PDB IDs		1Z2M 2HJ8 3PHX 3PSE 3R66 3RT3 3SDL 5TL6 5W8T 5W8U 6BI8 6FFA 6XA9 7RBS 7S6P 8OIF 8SE9 8SEA 8SEB 8SV8	6S7O 6S7T 8B6L 8PN9
Enriched GO Terms of Interacting Partners?		Cysteine-type Deubiquitinase Activity Protein Deubiquitination Regulation Of Protein Stability Protein Modification By Small Protein Removal Cysteine-type Peptidase Activity Protein Metabolic Process Post-translational Protein Modification Protein Modification Process Presynaptic Cytosol Muscle Thin Filament Tropomyosin Oligosaccharyltransferase Complex B Macromolecule Metabolic Process Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Proteolysis Ubiquitin Protein Ligase Binding Oligosaccharyltransferase Complex A Cytoplasm Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Cysteine-type Endopeptidase Activity Regulation Of Epithelial Cell Migration Oligosaccharyltransferase Complex Negative Regulation Of Catabolic Process Axonal Transport Of Mitochondrion Adenyl-nucleotide Exchange Factor Activity Regulation Of Proteolysis Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Nucleolus Peptidase Activity Ubiquitin Binding Cellular Response To Interleukin-4 Deubiquitinase Activity Protein K48-linked Deubiquitination Mitochondrion Transport Along Microtubule Response To Interleukin-4 Postsynaptic Cytosol Histone Deacetylase Binding Response To Cytokine RNA Binding Regulation Of Protein Metabolic Process Establishment Of Mitochondrion Localization Response To Peptide Proteolysis Positive Regulation Of Gene Expression Negative Regulation Of Protein Metabolic Process ISG15 Activating Enzyme Activity Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Positive Regulation Of Ribosome Biogenesis Hsp90 Protein Binding	Nucleoplasm Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Interferon-beta Production Septin Cytoskeleton Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Positive Regulation Of Type I Interferon Production Regulation Of Interferon-beta Production Leukotriene B4 Receptor Activity Cyclic-di-GMP Binding STING Complex 2',3'-cyclic GMP-AMP Binding Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Regulation Of Type I Interferon Production Leukotriene Receptor Activity Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Protein Oligomerization Leukotriene Signaling Pathway
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