PRDM1

Gene Name		PR domain containing 1, with ZNF domain
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Methyltransferase Activity Histone Deacetylase Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Maternal Placenta Development Transcription, DNA-templated Germ Cell Development Post-embryonic Development Positive Regulation Of Gene Expression Negative Regulation Of B Cell Proliferation Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Methylation Eye Photoreceptor Cell Development Cell Fate Commitment Positive Regulation Of B Cell Differentiation Intestinal Epithelial Cell Development Trophoblast Giant Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Crohn's disease ( 21102463) Systemic lupus erythematosus ( 23273568 19838193)
Protein-protein Interactions		9 interactors: AES ATXN1 HIST1H1A HIST2H3A IRF4 KDM1A PIAS1 TLE1 TLE2
Entrez ID		639
HPRD ID		04572
Ensembl ID		ENSG00000057657
Uniprot IDs		B4DW27 O75626
PDB IDs		3DAL
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cellular Metabolic Process Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signal Transduction Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Regulation Of Signaling Regulation Of Anoikis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Wnt Signaling Pathway Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Binding Positive Regulation Of Gene Expression Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Binding Organ Development Biosynthetic Process Regulation Of Primitive Erythrocyte Differentiation Positive Regulation Of Interleukin-13 Biosynthetic Process Regulation Of DNA Binding Negative Regulation Of Binding Regulation Of Metabolic Process Positive Regulation Of Interleukin-10 Biosynthetic Process Positive Regulation Of Interleukin-4 Biosynthetic Process Myeloid Leukocyte Differentiation Positive Regulation Of Transcription, DNA-templated Interferon-gamma-mediated Signaling Pathway Notch Signaling Pathway Response To Stimulus
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