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LIMK2 and ROCK1
Number of citations of the paper that reports this interaction (PubMedID
11340065
)
0
Data Source:
HPRD
(in vivo, in vitro)
LIMK2
ROCK1
Description
LIM domain kinase 2
Rho associated coiled-coil containing protein kinase 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cis-Golgi Network
Centrosome
Spindle
Cytoskeleton
Perinuclear Region Of Cytoplasm
Mitotic Spindle
Golgi Membrane
Ruffle
Extracellular Region
Cytoplasm
Golgi Apparatus
Centriole
Cytosol
Cytoskeleton
Plasma Membrane
Cytoplasmic Stress Granule
Membrane
Lamellipodium
Bleb
Secretory Granule Lumen
Cell Projection
Schaffer Collateral - CA1 Synapse
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Metal Ion Binding
Protein Serine Kinase Activity
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Kinase Activity
Transferase Activity
Small GTPase Binding
Metal Ion Binding
Tau Protein Binding
Tau-protein Kinase Activity
Rho-dependent Protein Serine/threonine Kinase Activity
Protein Serine Kinase Activity
Biological Process
Protein Phosphorylation
Spermatogenesis
Actin Cytoskeleton Organization
Astral Microtubule Organization
Establishment Of Vesicle Localization
Head Development
Cornea Development In Camera-type Eye
Positive Regulation Of Protein Localization To Nucleus
Negative Regulation Of Cilium Assembly
Mitotic Cytokinesis
Epithelial To Mesenchymal Transition
Aortic Valve Morphogenesis
Apical Constriction
Apoptotic Process
Smooth Muscle Contraction
Leukocyte Cell-cell Adhesion
Signal Transduction
Rho Protein Signal Transduction
Regulation Of Gene Expression
Positive Regulation Of Autophagy
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Gene Expression
Negative Regulation Of Angiogenesis
Peptidyl-serine Phosphorylation
Membrane To Membrane Docking
Actin Cytoskeleton Organization
Regulation Of Cell Adhesion
Regulation Of Cell Migration
Cortical Actin Cytoskeleton Organization
Actomyosin Structure Organization
Neuron Projection Development
Bleb Assembly
Negative Regulation Of Protein Binding
Regulation Of Actin Cytoskeleton Organization
Regulation Of Actin Filament-based Process
Intracellular Signal Transduction
Positive Regulation Of MAPK Cascade
Regulation Of Keratinocyte Differentiation
Regulation Of Neuron Differentiation
Positive Regulation Of Phosphate Metabolic Process
Embryonic Morphogenesis
Leukocyte Migration
Leukocyte Tethering Or Rolling
Negative Regulation Of Membrane Protein Ectodomain Proteolysis
Myoblast Migration
Regulation Of Stress Fiber Assembly
Regulation Of Focal Adhesion Assembly
Positive Regulation Of Focal Adhesion Assembly
MRNA Destabilization
Negative Regulation Of Biomineral Tissue Development
Regulation Of Microtubule Cytoskeleton Organization
Response To Transforming Growth Factor Beta
Protein Localization To Plasma Membrane
Regulation Of Synapse Maturation
Podocyte Cell Migration
Motor Neuron Apoptotic Process
Blood Vessel Diameter Maintenance
Regulation Of Angiotensin-activated Signaling Pathway
Neuron Projection Arborization
Positive Regulation Of Amyloid-beta Clearance
Regulation Of Synaptic Vesicle Endocytosis
Regulation Of Cell Junction Assembly
Regulation Of Amyloid-beta Formation
Negative Regulation Of Amyloid-beta Formation
Negative Regulation Of Amyloid Precursor Protein Catabolic Process
Regulation Of Establishment Of Endothelial Barrier
Negative Regulation Of Bicellular Tight Junction Assembly
Positive Regulation Of Connective Tissue Replacement
Response To Angiotensin
Regulation Of Establishment Of Cell Polarity
Regulation Of Cell Motility
Negative Regulation Of Motor Neuron Apoptotic Process
Pathways
EPHB-mediated forward signaling
Sema4D induced cell migration and growth-cone collapse
RHO GTPases Activate ROCKs
Apoptotic cleavage of cellular proteins
EPHB-mediated forward signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse
Sema4D induced cell migration and growth-cone collapse
VEGFA-VEGFR2 Pathway
RHO GTPases Activate ROCKs
RHO GTPases Activate ROCKs
Neutrophil degranulation
RHOA GTPase cycle
RHOB GTPase cycle
RHOC GTPase cycle
RHOH GTPase cycle
RHOBTB1 GTPase cycle
Potential therapeutics for SARS
RND3 GTPase cycle
Drugs
Fostamatinib
Hydroxyfasudil
(S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE
Fasudil
Y-27632
Ripasudil
Netarsudil
Belumosudil
Diseases
GWAS
Eosinophil count (
27863252
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
27863252
)
Fish- and plant-related diet (
32066663
)
Mean reticulocyte volume (
32888494
)
Multiple sclerosis (
31604244
)
Neutrophil percentage of granulocytes (
27863252
)
Oily fish consumption (
32066663
)
Paclitaxel-induced neuropathy (
23776197
)
Pork consumption (
32066663
)
Red cell distribution width (
32888494
)
Sum eosinophil basophil counts (
27863252
)
Type 2 diabetes nephropathy (
21150874
)
Asthma exacerbations in inhaled corticosteroid treatment (
30697902
)
Lysophosphatidylcholine levels (
31551469
)
Telomere length (
30185882
)
Interacting Genes
12 interacting genes:
CDC42BPA
CFL1
FBXO7
GSN
H1-1
HIPK3
LIMK1
MBP
NF1
PARD3
ROCK1
RPS6KA1
40 interacting genes:
ADD1
ARHGAP24
CASP3
CASP7
CDC25A
CDC34
CFAP206
CRMP1
DES
DPYSL2
EZR
FAM124A
GFAP
HMGB2
IKBKB
IRS1
ITSN2
LIMK1
LIMK2
LINC00452
LMO2
MAGEB4
MLC1
MSN
PFN2
POLR3C
PPP1R12A
PTK2
RDX
RHOA
RHOB
RHOC
RND3
SMAD2
SMAD5
TPPP
TRIM15
TSG101
UBE2T
VIM
Entrez ID
3985
6093
HPRD ID
03585
03414
Ensembl ID
ENSG00000182541
ENSG00000067900
Uniprot IDs
P53671
Q13464
PDB IDs
1X6A
4TPT
5NXD
7QHG
8GI4
8S3X
8WSW
1S1C
2ESM
2ETK
2ETR
2V55
3D9V
3NCZ
3NDM
3O0Z
3TV7
3TWJ
3V8S
4L2W
4W7P
4YVC
4YVE
5BML
5F5P
5HVU
5KKS
5KKT
5UZJ
5WNE
5WNF
5WNG
5WNH
6E9W
7JOU
7S25
7S26
8P0S
8ZH5
Enriched GO Terms of Interacting Partners
?
Lamellipodium
Actin Filament-based Process
Actin Cytoskeleton Organization
Regulation Of Establishment Of Cell Polarity
Regulation Of Establishment Or Maintenance Of Cell Polarity
Cytoskeleton Organization
Protein Serine Kinase Activity
Protein Phosphorylation
Internode Region Of Axon
Phosphorylation
Protein Serine/threonine Kinase Activity
Regulation Of Cellular Component Organization
Rho Protein Signal Transduction
Protein Kinase Activity
Actin Filament Depolymerization
Regulation Of Actin Filament Organization
Small GTPase-mediated Signal Transduction
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Regulation Of Protein Metabolic Process
Actin Filament Severing
Regulation Of Multicellular Organismal Process
Myelination
Axon Ensheathment
Kinase Activity
Actomyosin Structure Organization
Positive Regulation Of Multicellular Organismal Process
Myelination In Peripheral Nervous System
Positive Regulation Of Cellular Component Organization
Regulation Of Actin Cytoskeleton Organization
Regulation Of Cell-matrix Adhesion
Cytosol
Organelle Organization
Regulation Of Proteolysis
Regulation Of Actin Filament-based Process
Regulation Of Supramolecular Fiber Organization
Immune System Process
Muscle Cell Migration
Positive Regulation Of Cell Growth
Positive Regulation Of Focal Adhesion Assembly
Regulation Of Cell Development
Positive Regulation Of Supramolecular Fiber Organization
Negative Regulation Of Apoptotic Process
Intracellular Signaling Cassette
Fc-gamma Receptor Signaling Pathway
Positive Regulation Of Cytoskeleton Organization
Regulation Of Multicellular Organismal Development
Protein Depolymerization
Regulation Of Metabolic Process
Negative Regulation Of Programmed Cell Death
Focal Adhesion
Cytoskeleton
Supramolecular Fiber Organization
Regulation Of Cellular Component Organization
Cytoskeleton Organization
Regulation Of Cytoskeleton Organization
Cytoplasm
Cytosol
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Early Endosome To Late Endosome Transport
Positive Regulation Of Protein Localization To Early Endosome
Regulation Of Organelle Organization
Astral Microtubule Organization
Regulation Of Actin Filament-based Process
Actin Filament Organization
Positive Regulation Of Protein Localization To Endosome
Negative Regulation Of Cell Projection Organization
Regulation Of Protein-containing Complex Assembly
Skeletal Muscle Satellite Cell Migration
Positive Regulation Of Stress Fiber Assembly
Cleavage Furrow
Establishment Of Epithelial Cell Apical/basal Polarity
Protein Kinase Binding
Regulation Of Establishment Of Endothelial Barrier
Regulation Of Early Endosome To Late Endosome Transport
Positive Regulation Of Actin Filament Bundle Assembly
Actin Filament Bundle Assembly
Cytoplasmic Microtubule Organization
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Actin Filament Bundle Organization
Actin Cytoskeleton Organization
Developmental Process
Establishment Of Apical/basal Cell Polarity
Regulation Of Cell Projection Organization
Intracellular Signaling Cassette
Polarized Epithelial Cell Differentiation
Cytoskeletal Protein Binding
Establishment Of Monopolar Cell Polarity
Establishment Or Maintenance Of Monopolar Cell Polarity
Regulation Of Cellular Component Size
Regulation Of Organelle Assembly
Negative Regulation Of Cellular Component Organization
Regulation Of Actin Filament Organization
Cellular Developmental Process
Cellular Response To Staurosporine
Cell Differentiation
Actin Filament-based Process
Wound Healing, Spreading Of Cells
Establishment Of Epithelial Cell Polarity
Regulation Of Adherens Junction Organization
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Tagcloud (Difference)
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Tagcloud (Intersection)
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