LIMK2 and GSN

Number of citations: 41 (PubMedID 11171090)
Data Source: HPRD (in vitro)

		LIMK2	GSN
Name		LIM domain kinase 2	gelsolin
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cis-Golgi Network Centrosome Spindle Cytoskeleton Perinuclear Region Of Cytoplasm Mitotic Spindle	Podosome Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Sarcoplasm Lamellipodium Actin Cap Cortical Actin Cytoskeleton Secretory Granule Lumen Phagocytic Vesicle Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Actin Binding Calcium Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol 3-kinase Catalytic Subunit Binding Myosin II Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Protein Phosphorylation Spermatogenesis Actin Cytoskeleton Organization Astral Microtubule Organization Establishment Of Vesicle Localization Head Development Cornea Development In Camera-type Eye Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Cilium Assembly	Phagocytosis, Engulfment Actin Filament Organization Central Nervous System Development Actin Polymerization Or Depolymerization Positive Regulation Of Gene Expression Striated Muscle Atrophy Vesicle-mediated Transport Extracellular Matrix Disassembly Cell Projection Organization Cell Projection Assembly Actin Cytoskeleton Organization Actin Filament Polymerization Actin Filament Depolymerization Protein Destabilization Response To Muscle Stretch Positive Regulation Of Apoptotic Process Host-mediated Suppression Of Symbiont Invasion Actin Filament Severing Barbed-end Actin Filament Capping Positive Regulation Of Actin Nucleation Actin Filament Capping Relaxation Of Cardiac Muscle Cilium Assembly Cellular Response To Type II Interferon Regulation Of Podosome Assembly Cardiac Muscle Cell Contraction Renal Protein Absorption Hepatocyte Apoptotic Process Positive Regulation Of Keratinocyte Apoptotic Process Regulation Of Establishment Of T Cell Polarity Regulation Of Plasma Membrane Raft Polarization Regulation Of Receptor Clustering Positive Regulation Of Protein Processing In Phagocytic Vesicle Amyloid Fibril Formation
Pathways		EPHB-mediated forward signaling Sema4D induced cell migration and growth-cone collapse RHO GTPases Activate ROCKs	Caspase-mediated cleavage of cytoskeletal proteins Neutrophil degranulation Sensory processing of sound by outer hair cells of the cochlea Amyloid fiber formation
Drugs		Fostamatinib	Zinc Latrunculin A Copper Zinc acetate
Diseases		None	Lattice corneal dystrophies (LCD), including: Biber-Haab-Dimmer dystrophy; Familial amyloid polyneuropathy type IV; Meretoja syndrome Familial amyloidosis
GWAS		Eosinophil count ( 27863252 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 27863252 ) Fish- and plant-related diet ( 32066663 ) Mean reticulocyte volume ( 32888494 ) Multiple sclerosis ( 31604244 ) Neutrophil percentage of granulocytes ( 27863252 ) Oily fish consumption ( 32066663 ) Paclitaxel-induced neuropathy ( 23776197 ) Pork consumption ( 32066663 ) Red cell distribution width ( 32888494 ) Sum eosinophil basophil counts ( 27863252 ) Type 2 diabetes nephropathy ( 21150874 )	Blood protein levels ( 30072576 )
Novel Interactors		1 novel interactors: FCGR2A	3 novel interactors: POLE3 RAB14 TRIM32
Interacting Genes		12 interacting genes: CDC42BPA CFL1 FBXO7 GSN H1-1 HIPK3 LIMK1 MBP NF1 PARD3 ROCK1 RPS6KA1	28 interacting genes: ACTA1 ACTB ACTG1 ACTN4 APP AR BCAR1 CASP3 CEBPA CLIC5 CSK ERBB2 FHIT FN1 HSP90AA1 LIMK2 PDE4B PIK3CG PLCG1 PTK2B PXN STK39 TNIK TOM1L1 VASP VCL VDAC1 WEE2-AS1
Entrez ID		3985	2934
HPRD ID		03585	00674
Ensembl ID		ENSG00000182541	ENSG00000148180
Uniprot IDs		P53671	A0A0A0MS51 A0A0A0MT01 A0A384MEF1 A0A8V8TND7 B7Z4U6 P06396
PDB IDs		1X6A 4TPT 5NXD 7QHG 8GI4 8S3X 8WSW	1C0F 1C0G 1D4X 1DEJ 1EQY 1ESV 1H1V 1KCQ 1MDU 1NLV 1NM1 1NMD 1P8X 1P8Z 1SOL 1T44 1YAG 1YVN 2FF3 2FF6 2FH1 2FH2 2FH3 2FH4 3A5L 3A5M 3A5N 3A5O 3CI5 3CIP 3CJB 3CJC 3FFK 3FFN 3TU5 4PKG 4PKH 4PKI 4S10 4Z94 5FAE 5FAF 5H3M 5H3N 5O2Z 5UBO 5ZZ0 6H1F 6JCO 6JEG 6JEH 6LJE 6LJF 6Q9R 6Q9Z 6QBF 6QW3 7P2B 8VIZ 8VKH
GO Terms Enriched among Interactors		Lamellipodium Actin Filament-based Process Actin Cytoskeleton Organization Regulation Of Establishment Of Cell Polarity Regulation Of Establishment Or Maintenance Of Cell Polarity Cytoskeleton Organization Protein Serine Kinase Activity Protein Phosphorylation Internode Region Of Axon Phosphorylation Protein Serine/threonine Kinase Activity Regulation Of Cellular Component Organization Rho Protein Signal Transduction Protein Kinase Activity Actin Filament Depolymerization Regulation Of Actin Filament Organization Small GTPase-mediated Signal Transduction Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Actin Filament Severing Regulation Of Multicellular Organismal Process Myelination Axon Ensheathment Kinase Activity Actomyosin Structure Organization Positive Regulation Of Multicellular Organismal Process Myelination In Peripheral Nervous System Positive Regulation Of Cellular Component Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Cell-matrix Adhesion Cytosol Organelle Organization Regulation Of Proteolysis Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Immune System Process Muscle Cell Migration Positive Regulation Of Cell Growth Positive Regulation Of Focal Adhesion Assembly Regulation Of Cell Development Positive Regulation Of Supramolecular Fiber Organization Negative Regulation Of Apoptotic Process Intracellular Signaling Cassette Fc-gamma Receptor Signaling Pathway Positive Regulation Of Cytoskeleton Organization Regulation Of Multicellular Organismal Development Protein Depolymerization Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death	Cell Surface Receptor Signaling Pathway Regulation Of Monoatomic Cation Transmembrane Transport Lamellipodium Actin Cytoskeleton Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Locomotion Multicellular Organismal-level Homeostasis Regulation Of Metal Ion Transport Regulation Of Cellular Component Organization Regulation Of Immune System Process Regulation Of Calcium Ion Transmembrane Transport Regulation Of Apoptotic Process Nucleotide Binding Regulation Of Monoatomic Ion Transport Regulation Of Cell Migration Regulation Of Programmed Cell Death Focal Adhesion Extracellular Exosome Positive Regulation Of Immune System Process Anatomical Structure Homeostasis Tissue Homeostasis Regulation Of Cell Adhesion Regulation Of Cell Motility Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cytosol Regulation Of Transport Regulation Of Locomotion Platelet Aggregation Plasma Membrane Regulation Of MAPK Cascade Regulation Of Multicellular Organismal Process ATP Binding Regulation Of Calcium Ion Transport Actin Cytoskeleton Organization Signal Transduction Transmembrane Transporter Binding Positive Regulation Of Gene Expression Identical Protein Binding Homotypic Cell-cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway Actin Filament-based Process Cytoplasm Positive Regulation Of Protein Metabolic Process Cell Motility ERBB Signaling Pathway Cell Body Protein Kinase Binding Positive Regulation Of MAPK Cascade