LIMK2

Name	LIM domain kinase 2
Structure
Novel Interactors	1 novel interactors: FCGR2A
Interactors	12 interactors: CDC42BPA CFL1 FBXO7 GSN H1-1 HIPK3 LIMK1 MBP NF1 PARD3 ROCK1 RPS6KA1
GO Annotations	Cellular Component	Nucleus Cytoplasm Cis-Golgi Network Centrosome Spindle Cytoskeleton Perinuclear Region Of Cytoplasm Mitotic Spindle
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation Spermatogenesis Actin Cytoskeleton Organization Astral Microtubule Organization Establishment Of Vesicle Localization Head Development Cornea Development In Camera-type Eye Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Cilium Assembly
Pathways	EPHB-mediated forward signaling Sema4D induced cell migration and growth-cone collapse RHO GTPases Activate ROCKs
Drugs	Fostamatinib
GWAS	Eosinophil count ( 27863252 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 27863252 ) Fish- and plant-related diet ( 32066663 ) Mean reticulocyte volume ( 32888494 ) Multiple sclerosis ( 31604244 ) Neutrophil percentage of granulocytes ( 27863252 ) Oily fish consumption ( 32066663 ) Paclitaxel-induced neuropathy ( 23776197 ) Pork consumption ( 32066663 ) Red cell distribution width ( 32888494 ) Sum eosinophil basophil counts ( 27863252 ) Type 2 diabetes nephropathy ( 21150874 )
Entrez ID	3985
HPRD ID	03585
Ensembl ID	ENSG00000182541
Uniprot IDs	P53671
PDB IDs	1X6A 4TPT 5NXD 7QHG 8GI4 8S3X 8WSW
GO Terms Enriched among Interactors ?	Lamellipodium Actin Filament-based Process Actin Cytoskeleton Organization Regulation Of Establishment Of Cell Polarity Regulation Of Establishment Or Maintenance Of Cell Polarity Cytoskeleton Organization Protein Serine Kinase Activity Protein Phosphorylation Internode Region Of Axon Phosphorylation Protein Serine/threonine Kinase Activity Regulation Of Cellular Component Organization Rho Protein Signal Transduction Protein Kinase Activity Actin Filament Depolymerization Regulation Of Actin Filament Organization Small GTPase-mediated Signal Transduction Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Actin Filament Severing Regulation Of Multicellular Organismal Process Myelination Axon Ensheathment Kinase Activity Actomyosin Structure Organization Positive Regulation Of Multicellular Organismal Process Myelination In Peripheral Nervous System Positive Regulation Of Cellular Component Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Cell-matrix Adhesion Cytosol Organelle Organization Regulation Of Proteolysis Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Immune System Process Muscle Cell Migration Positive Regulation Of Cell Growth Positive Regulation Of Focal Adhesion Assembly Regulation Of Cell Development Positive Regulation Of Supramolecular Fiber Organization Negative Regulation Of Apoptotic Process Intracellular Signaling Cassette Fc-gamma Receptor Signaling Pathway Positive Regulation Of Cytoskeleton Organization Regulation Of Multicellular Organismal Development Protein Depolymerization Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death