H3-3A and TLE2

Number of citations of the paper that reports this interaction (PubMedID 9334241)
0

Data Source:
HPRD (in vivo)

		H3-3A	TLE2
Description		H3.3 histone A	TLE family member 2, transcriptional corepressor
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromosome, Telomeric Region Chromatin Nucleosome Inner Kinetochore Barr Body Extracellular Region Nucleus Nucleoplasm Chromosome Protein-containing Complex Extracellular Exosome	Extracellular Space Nucleus Nucleoplasm Transcription Regulator Complex Focal Adhesion Nuclear Body
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA Binding Protein Binding Structural Constituent Of Chromatin Nucleosomal DNA Binding Protein Heterodimerization Activity	Transcription Corepressor Activity Protein Binding
	Biological Process	Oocyte Maturation Osteoblast Differentiation Nucleosome Assembly Nucleus Organization Spermatogenesis Spermatid Development Single Fertilization Embryo Implantation Cell Population Proliferation Male Gonad Development Positive Regulation Of Cell Growth Pericentric Heterochromatin Formation Subtelomeric Heterochromatin Formation Telomere Organization Multicellular Organism Growth Muscle Cell Differentiation Oogenesis Regulation Of Centromere Complex Assembly Negative Regulation Of Chromosome Condensation	Regulation Of DNA-templated Transcription Signal Transduction Animal Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Assembly of the ORC complex at the origin of replication RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Replacement of protamines by nucleosomes in the male pronucleus Factors involved in megakaryocyte development and platelet production MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription	Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes
Drugs
Diseases
GWAS
Interacting Genes		44 interacting genes: ASF1A ASF1B BPTF BRD7 CARM1 CBX2 CBX4 CBX6 CBX7 CBX8 CEBPA CHD1 CREBBP DCAF1 EP300 ESR1 HMGB2 HPF1 KAT2B KMT2A MAPK9 NEDD4 NOS3 PARP10 PARP2 PELP1 PIM1 PPM1D PPP1CA PPP1CB SET SETD7 SMARCA1 SMARCA4 SMARCA5 SS18 SSRP1 SUPT16H SUV39H1 TIAM1 TLE2 UBN1 UHRF1 ZMYND11	16 interacting genes: BARHL1 EMX2 FOXA3 H3-3A HES1 HMGB1 LEF1 MSX1 MSX2 PAX9 PRDM1 RUNX1 TLE1 TLX3 UTY VENTX
Entrez ID		3020	7089
HPRD ID		03082	03025
Ensembl ID		ENSG00000163041	ENSG00000065717
Uniprot IDs		B2R4P9 P84243	K7EMK7 Q04725
PDB IDs		2L43 3ASK 3ASL 3AV2 3JVK 3MUK 3MUL 3QL9 3QLA 3QLC 3WTP 4GNE 4GNF 4GNG 4GU0 4GUR 4GUS 4GY5 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA 4L58 4N4I 4O62 4QQ4 4TMP 4U7T 4W5A 5B32 5B33 5BNV 5BNX 5DWQ 5DX0 5JA4 5JJY 5JLB 5KDM 5X7X 6A5L 6A5O 6A5P 6A5R 6A5T 6A5U 6HGT 6INQ 6IR9 6J4W 6J4X 6J4Y 6J4Z 6J50 6J51 6J9J 6PZV 6QXZ 6R0C 6RNY 6U04 7A08 7CIZ 7CJ0 7CWH 7OKP 7V1L 7V1M 7VCQ 7W5M 7WBV 7WBW 7WBX 7XSE 7XSX 7XSZ 7XT7 7XTD 7XTI 8JH2 8JH3 8JH4 8KB5 9B3P 9EOZ 9J0N 9J0O 9J0P
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Remodeling Chromatin Binding Nucleoplasm Nucleus Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromatin Negative Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Nucleosome Organization Negative Regulation Of Macromolecule Metabolic Process Chromosome Regulation Of Macromolecule Metabolic Process Histone Binding Negative Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Cellular Response To Stress Protein-DNA Complex Assembly DNA Damage Response Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Nucleosome Assembly Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process PRC1 Complex Rhythmic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Epigenetic Regulation Of Gene Expression DNA Metabolic Process PcG Protein Complex Positive Regulation Of Macromolecule Metabolic Process N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Biosynthetic Process Nucleosome Binding Nucleic Acid Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Repair Nucleolus Positive Regulation Of Metabolic Process	Sequence-specific Double-stranded DNA Binding Chromatin DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Developmental Process Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Cell Differentiation Animal Organ Development Cell Population Proliferation Nucleus Anterior/posterior Pattern Specification Positive Regulation Of Transcription By RNA Polymerase II Cellular Developmental Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding BMP Signaling Pathway Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Primary Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Odontogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific DNA Binding Positive Regulation Of Mesenchymal Cell Apoptotic Process Positive Regulation Of Biosynthetic Process Face Morphogenesis DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regionalization Midbrain Development Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Animal Organ Morphogenesis Embryonic Nail Plate Morphogenesis Positive Regulation Of BMP Signaling Pathway Tube Morphogenesis Negative Regulation Of Biosynthetic Process
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