H3F3A and SMARCA5

Number of citations of the paper that reports this interaction (PMID 16728976)
287

Data Source:
HPRD (in vitro)

		H3F3A	SMARCA5
Gene Name		H3 histone, family 3A	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Nuclear Nucleosome Extracellular Region Nucleus Nucleoplasm Protein Complex Extracellular Vesicular Exosome	Condensed Chromosome Nucleus Nucleoplasm Chromatin Silencing Complex Nucleolus NURF Complex RSF Complex Nuclear Replication Fork
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Protein Binding Nucleosomal DNA Binding Protein Heterodimerization Activity	DNA Binding Helicase Activity Protein Binding ATP Binding ATPase Activity Nucleosome Binding Histone Binding
	Biological Process	Chromatin Silencing At RDNA DNA Replication-independent Nucleosome Assembly Blood Coagulation Gene Expression Positive Regulation Of Cell Growth DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic	Chromatin Silencing At RDNA Double-strand Break Repair Nucleosome Assembly Chromatin Remodeling DNA-templated Transcription, Initiation Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Nucleosome Positioning CENP-A Containing Nucleosome Assembly Regulation Of Gene Expression, Epigenetic ATP-dependent Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Cellular Senescence Signaling by Wnt M Phase Amyloids NoRC negatively regulates rRNA expression RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression Factors involved in megakaryocyte development and platelet production PRC2 methylates histones and DNA Cell Cycle, Mitotic Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes	NoRC negatively regulates rRNA expression Chromosome Maintenance Nucleosome assembly Deposition of new CENPA-containing nucleosomes at the centromere Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression
Drugs
Diseases
GWAS
Protein-Protein Interactions		25 interactors: ASF1A ASF1B BPTF BRD1 CABIN1 CARM1 CBX3 CHD1 CREBBP DAXX KAT2B KMT2A MAPK9 NOS3 PARP10 SETD7 SMARCA1 SMARCA4 SMARCA5 SS18 SSRP1 SUPT16H TLE2 UHRF1 ZMYND11	17 interactors: BAZ1A BAZ1B BAZ2A CDT1 CHRAC1 CREB1 CTNNB1 DNMT3B H3F3A HDAC2 HIST1H3A HIST4H4 MAF POLE3 RAD21 RSF1 SATB1
Entrez ID		3020	8467
HPRD ID		03082	04538
Ensembl ID		ENSG00000163041	ENSG00000153147
Uniprot IDs		B2R4P9 P84243	O60264
PDB IDs		2L43 3ASK 3ASL 3AV2 3JVK 3MUK 3MUL 3QL9 3QLA 3QLC 4GNE 4GNF 4GNG 4GU0 4GUR 4GUS 4GY5 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA 4L58
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Modification Chromosome Organization Organelle Organization Transcription, DNA-templated RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Metabolic Process Chromatin Remodeling Gene Expression Biosynthetic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleosome Organization Chromatin Assembly Or Disassembly Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Histone Modification Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Cellular Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process DNA Replication-independent Nucleosome Assembly Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Nucleosome Assembly Internal Protein Amino Acid Acetylation Peptidyl-lysine Modification Protein Acetylation Chromatin Assembly Negative Regulation Of Cellular Metabolic Process DNA Conformation Change Negative Regulation Of Biosynthetic Process Protein-DNA Complex Assembly Negative Regulation Of Transcription, DNA-templated Regulation Of Cellular Process Viral Process	Chromatin Organization Chromatin Silencing Chromosome Organization Chromatin Remodeling Nucleobase-containing Compound Metabolic Process Chromatin Modification Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Organelle Organization Negative Regulation Of Gene Expression, Epigenetic DNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Gene Silencing Regulation Of Gene Expression, Epigenetic DNA Methylation On Cytosine Negative Regulation Of Gene Expression Chromatin Silencing At RDNA Negative Regulation Of Biosynthetic Process DNA Methylation Regulation Of Transcription, DNA-templated Chromatin Assembly Or Disassembly Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process DNA Modification Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Gene Expression Chromatin Assembly DNA Packaging Histone Modification Methylation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Metabolic Process DNA Conformation Change Fungiform Papilla Formation Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Regulation Of Metabolic Process Nucleosome Organization Fungiform Papilla Morphogenesis Protein-DNA Complex Assembly Transcription, DNA-templated Fungiform Papilla Development
Tagcloud ?		36me3 atrx code combinatorial commonest daxx g34r g34v gbms global h3k h3k27me3 h3k36me3 h3k4me3 h3k9me3 highlights hist1h3b idh1 innovative k27m mark marks notably opportunity pediatric polycomb tailored trimethylation underlies	baz2a bc bladder characterizing fgfr3 formulation lowered messenger micrornas mir mirna mtor oncogenes oncogenesis oncomir ploidy promoted promoting qrt representative respective rnas rt4 supposed t24 thap2 today transfection urothelial
Tagcloud (Difference) ?		36me3 atrx code combinatorial commonest daxx g34r g34v gbms global h3k h3k27me3 h3k36me3 h3k4me3 h3k9me3 highlights hist1h3b idh1 innovative k27m mark marks notably opportunity pediatric polycomb tailored trimethylation underlies	baz2a bc bladder characterizing fgfr3 formulation lowered messenger micrornas mir mirna mtor oncogenes oncogenesis oncomir ploidy promoted promoting qrt representative respective rnas rt4 supposed t24 thap2 today transfection urothelial
Tagcloud (Intersection) ?