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H3-3A and UHRF1
Number of citations of the paper that reports this interaction (PubMedID
36089195
)
82
Data Source:
BioGRID
(enzymatic study, proximity labelling technology, affinity chromatography technology)
H3-3A
UHRF1
Description
H3.3 histone A
ubiquitin like with PHD and ring finger domains 1
Image
GO Annotations
Cellular Component
Chromosome, Centromeric Region
Chromosome, Telomeric Region
Chromatin
Nucleosome
Inner Kinetochore
Barr Body
Extracellular Region
Nucleus
Nucleoplasm
Chromosome
Protein-containing Complex
Extracellular Exosome
Chromatin
Euchromatin
Heterochromatin
Nucleus
Nucleoplasm
Replication Fork
Spindle
Nuclear Matrix
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
DNA Binding
Protein Binding
Structural Constituent Of Chromatin
Nucleosomal DNA Binding
Protein Heterodimerization Activity
Cis-regulatory Region Sequence-specific DNA Binding
Nucleic Acid Binding
DNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Methyl-CpG Binding
Transferase Activity
Histone Binding
Identical Protein Binding
Hemi-methylated DNA-binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Histone H3K9me2/3 Reader Activity
DNA Damage Sensor Activity
Histone H3 Ubiquitin Ligase Activity
Biological Process
Oocyte Maturation
Osteoblast Differentiation
Nucleosome Assembly
Nucleus Organization
Spermatogenesis
Spermatid Development
Single Fertilization
Embryo Implantation
Cell Population Proliferation
Male Gonad Development
Positive Regulation Of Cell Growth
Pericentric Heterochromatin Formation
Subtelomeric Heterochromatin Formation
Telomere Organization
Multicellular Organism Growth
Muscle Cell Differentiation
Oogenesis
Regulation Of Centromere Complex Assembly
Negative Regulation Of Chromosome Condensation
Negative Regulation Of Transcription By RNA Polymerase II
Double-strand Break Repair Via Homologous Recombination
DNA Repair
Chromatin Organization
Ubiquitin-dependent Protein Catabolic Process
Response To Stress
DNA Damage Response
Protein Ubiquitination
Heterochromatin Formation
Homologous Recombination
Epigenetic Regulation Of Gene Expression
Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Protein Metabolic Process
Protein Autoubiquitination
Mitotic Spindle Assembly
Pathways
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Assembly of the ORC complex at the origin of replication
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Defective pyroptosis
Negative Regulation of CDH1 Gene Transcription
Amyloid fiber formation
Chromatin modifications during the maternal to zygotic transition (MZT)
Replacement of protamines by nucleosomes in the male pronucleus
Factors involved in megakaryocyte development and platelet production
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Regulation of PD-L1(CD274) transcription
DNA methylation
Chromatin modifications during the maternal to zygotic transition (MZT)
Drugs
Diseases
GWAS
Age at first sexual intercourse (
34211149
)
Appendicular lean mass (
33097823
)
Birth weight (
31043758
)
Hip circumference adjusted for BMI (
34021172
)
Medication use (agents acting on the renin-angiotensin system) (
31015401
)
Mental health study participation (completed survey) (
31263887
)
Systolic blood pressure (
30578418
)
Type 2 diabetes (
30297969
)
Urate levels (
31578528
)
Interacting Genes
44 interacting genes:
ASF1A
ASF1B
BPTF
BRD7
CARM1
CBX2
CBX4
CBX6
CBX7
CBX8
CEBPA
CHD1
CREBBP
DCAF1
EP300
ESR1
HMGB2
HPF1
KAT2B
KMT2A
MAPK9
NEDD4
NOS3
PARP10
PARP2
PELP1
PIM1
PPM1D
PPP1CA
PPP1CB
SET
SETD7
SMARCA1
SMARCA4
SMARCA5
SS18
SSRP1
SUPT16H
SUV39H1
TIAM1
TLE2
UBN1
UHRF1
ZMYND11
36 interacting genes:
AKT1
ATR
DNMT3A
ERCC1
ERG
FANCD2
FZR1
H2AC4
H2BC3
H3-3A
H3-4
H3C1
H3C13
H3C14
H3C15
H4C14
KAT5
KIF11
LASP1
LIG1
MBD4
MUS81
NR3C1
PCLAF
PCNA
PLK1
PRKACA
SAP30
TP53
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2N
UHRF2
USP7
Entrez ID
3020
29128
HPRD ID
03082
06992
Ensembl ID
ENSG00000163041
ENSG00000276043
Uniprot IDs
B2R4P9
P84243
A0A087WVR3
Q96T88
PDB IDs
2L43
3ASK
3ASL
3AV2
3JVK
3MUK
3MUL
3QL9
3QLA
3QLC
3WTP
4GNE
4GNF
4GNG
4GU0
4GUR
4GUS
4GY5
4H9N
4H9O
4H9P
4H9Q
4H9R
4H9S
4HGA
4L58
4N4I
4O62
4QQ4
4TMP
4U7T
4W5A
5B32
5B33
5BNV
5BNX
5DWQ
5DX0
5JA4
5JJY
5JLB
5KDM
5X7X
6A5L
6A5O
6A5P
6A5R
6A5T
6A5U
6HGT
6INQ
6IR9
6J4W
6J4X
6J4Y
6J4Z
6J50
6J51
6J9J
6PZV
6QXZ
6R0C
6RNY
6U04
7A08
7CIZ
7CJ0
7CWH
7OKP
7V1L
7V1M
7VCQ
7W5M
7WBV
7WBW
7WBX
7XSE
7XSX
7XSZ
7XT7
7XTD
7XTI
8JH2
8JH3
8JH4
8KB5
9B3P
9EOZ
9J0N
9J0O
9J0P
2FAZ
2L3R
2LGG
2LGK
2LGL
2PB7
3ASK
3ASL
3BI7
3CLZ
3DB3
3DB4
3DWH
3FL2
3SHB
3SOU
3SOW
3SOX
3T6R
3ZVY
3ZVZ
4GY5
4QQD
5C6D
5IAY
5XPI
5YY9
5YYA
6B9M
6IIW
6VCS
6VED
6VYJ
6W92
7FB7
8JIG
8WMS
8XV4
8XV6
8XV7
8XV8
Enriched GO Terms of Interacting Partners
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Chromatin Organization
Chromatin Remodeling
Chromatin Binding
Nucleoplasm
Nucleus
Regulation Of DNA-templated Transcription
Negative Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Chromatin
Negative Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Nucleosome Organization
Negative Regulation Of Macromolecule Metabolic Process
Chromosome
Regulation Of Macromolecule Metabolic Process
Histone Binding
Negative Regulation Of Metabolic Process
Regulation Of Primary Metabolic Process
Cellular Response To Stress
Protein-DNA Complex Assembly
DNA Damage Response
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Metabolic Process
Nucleosome Assembly
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Metabolic Process
PRC1 Complex
Rhythmic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Epigenetic Regulation Of Gene Expression
DNA Metabolic Process
PcG Protein Complex
Positive Regulation Of Macromolecule Metabolic Process
N-terminal Peptidyl-lysine Acetylation
Positive Regulation Of Biosynthetic Process
Nucleosome Binding
Nucleic Acid Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
DNA Repair
Nucleolus
Positive Regulation Of Metabolic Process
Nucleoplasm
Nucleus
DNA Repair
Nucleosome
Chromosome
Structural Constituent Of Chromatin
Chromatin Organization
Chromatin Remodeling
DNA Metabolic Process
DNA Damage Response
DNA Binding
Nucleosome Assembly
Nucleosome Organization
Cellular Response To Stress
Chromosome Organization
Protein Heterodimerization Activity
Chromosome, Telomeric Region
Protein-DNA Complex Assembly
Macromolecule Metabolic Process
Telomere Organization
Negative Regulation Of Macromolecule Metabolic Process
Double-strand Break Repair
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Signal Transduction In Response To DNA Damage
DNA Damage Checkpoint Signaling
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Nucleic Acid Metabolic Process
Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
TORC1 Signaling
Response To Radiation
Negative Regulation Of TORC1 Signaling
Protein-containing Complex
Mitotic DNA Damage Checkpoint Signaling
Protein Ubiquitination
Negative Regulation Of Transcription By RNA Polymerase II
Mitotic DNA Integrity Checkpoint Signaling
Chromatin Binding
Response To Ionizing Radiation
Regulation Of DNA Metabolic Process
Regulation Of Chromosome Organization
Ubiquitin Conjugating Enzyme Activity
Response To UV
TOR Signaling
Cellular Response To Nutrient Levels
Regulation Of Cell Cycle
Protein Modification By Small Protein Conjugation
Regulation Of Cellular Response To Stress
Negative Regulation Of TOR Signaling
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