PSMD4 and TMEM129

Number of citations of the paper that reports this interaction (PubMedID 24807418)
53

Data Source:
BioGRID (enzymatic study)

		PSMD4	TMEM129
Description		proteasome 26S subunit ubiquitin receptor, non-ATPase 4	transmembrane protein 129, E3 ubiquitin ligase
Image			No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytosol Proteasome Regulatory Particle, Base Subcomplex Proteasome Accessory Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	RNA Binding Protein Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Molecular Adaptor Activity	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Response To Unfolded Protein Protein Ubiquitination Retrograde Protein Transport, ER To Cytosol ERAD Pathway
Pathways		Proteasome assembly Proteasome assembly	E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Body mass index ( 26426971) Hip circumference adjusted for BMI ( 34021172)	Bladder cancer ( 20972438 24163127) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 1 diabetes ( 33830302) Urinary bladder cancer ( 20348956) Walking pace ( 33128006)
Interacting Genes		46 interacting genes: ADRM1 APP BTRC CCNA2 CFTR CUL1 EGFR FBXO25 FLOT1 GNB5 H2AC4 H2BC3 ID1 MAP3K1 MDM2 MYOD1 NEDD4 NEDD4L NEDD8 NUB1 OGT PRKN PTEN RAD23A RAD23B RASSF8 RBCK1 RBM11 SCHIP1 SIAH2 SMURF1 SREBF2 STUB1 TCF3 TCP11L1 TMEM129 TP53 TRIM63 UBB UBC UBD UBE2C UBQLN1 UBQLN2 WWP2 XPC	6 interacting genes: DLC1 MSANTD3 PDGFRL PSMD4 UBE2D1 UBE2D3
Entrez ID		5710	92305
HPRD ID		03386	14290
Ensembl ID		ENSG00000159352	ENSG00000168936
Uniprot IDs		P55036 Q5VWC4	A0AVI4
PDB IDs		1P9C 1P9D 1UEL 1YX4 1YX5 1YX6 2KDE 2KDF 5GJQ 5GJR 5L4K 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHS 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6MUN 6U19 6WJD 6WJN 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8CVT 8JRI 8JRT 8JTI 8K0G 8USB 8USC 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O 9E8Q
Enriched GO Terms of Interacting Partners?		Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasomal Protein Catabolic Process Protein Modification By Small Protein Conjugation Proteolysis Macromolecule Catabolic Process Post-translational Protein Modification Regulation Of Proteolysis Protein Catabolic Process Protein Modification Process Regulation Of Protein Catabolic Process Protein Metabolic Process Positive Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Ubiquitin-protein Transferase Activity Regulation Of Proteasomal Protein Catabolic Process Ubiquitin Protein Ligase Activity Protein Polyubiquitination Positive Regulation Of Protein Metabolic Process Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleus Cytosol Ubiquitin Protein Ligase Binding Positive Regulation Of Macromolecule Metabolic Process Nucleoplasm Positive Regulation Of Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Primary Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Enzyme Binding Proteasome Binding Cytoplasm Cellular Response To Stress Protein-folding Chaperone Binding Ubiquitin Binding Regulation Of Metabolic Process Negative Regulation Of Potassium Ion Export Across Plasma Membrane Protein Monoubiquitination Ubiquitin Ligase Complex Regulation Of Signal Transduction Protein Destabilization	Ubiquitin Conjugating Enzyme Activity Platelet-derived Growth Factor Beta-receptor Activity Platelet-derived Growth Factor Receptor Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of BMP Signaling Pathway Protein K48-linked Ubiquitination Regulation Of BMP Signaling Pathway Hindbrain Morphogenesis Negative Regulation Of Cellular Response To Growth Factor Stimulus Protein Catabolic Process Platelet Activating Factor Receptor Activity Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Platelet-derived Growth Factor Receptor-beta Signaling Pathway Ubiquitin-protein Transferase Activity Macromolecule Catabolic Process Proteasome Regulatory Particle, Base Subcomplex Protein Polyubiquitination Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
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