PSMD4 and NEDD4L

  • Number of citations of the paper that reports this interaction (PMID 20542005)
  • 28
  • Data Source:
  • BioGRID (enzymatic study)

PSMD4

NEDD4L

Gene Name proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Insomnia (caffeine-induced) ( 22754043)
  • Liver enzyme levels (gamma-glutamyl transferase) ( 22001757)
  • Response to amphetamines ( 22952603)
Protein-Protein Interactions 41 interactors: ADRM1 APP BTRC CCNA2 CCNB1 COPS2 COPS7A CUL1 EGFR ELSPBP1 FBXO25 FLOT1 GNB5 ID1 MDM2 MYOD1 NEDD4 NEDD4L NEDD8 NUB1 NUPR1 PARK2 PSMC2 RAD23A RAD23B RASSF8 RBCK1 SCHIP1 SIAH2 SREBF2 STUB1 TCF3 TRIM63 UBB UBC UBE2C UBE3A UBQLN1 UBQLN2 UBQLN4 XPC 126 interactors: AATF ABL1 ABL2 ACVR1B ACY3 ADAP2 AICDA AKT3 APEX2 ARHGDIA AURKC BBX BMPR1A BRAF C7orf50 CACNB1 CAMK1D CDC34 CDK3 CDK5 CLIC2 CUEDC1 CYBRD1 CYP26B1 DAPK3 DAZAP2 DDX54 DECR2 DMTN DYRK3 EFEMP2 FGF12 FKBP3 GORAB H1F0 HAX1 HGS IFRD2 IKBKB KCNAB1 KCNAB2 KCNAB3 KCNB1 KIF3B KIFC3 LAPTM5 MAGEB1 MAP2 MAP3K2 MAP3K3 MAP3K5 MAPKAPK3 MARK2 MERTK MINK1 MOB3A MRPL19 NDFIP2 NHP2 NR3C1 NSRP1 NTRK1 NUDT16L1 PBX1 PRKX PRR16 PRRG1 PSMD4 RANBP10 RASL10B RASL11B RNF11 RNF7 ROBO3 RPL30 RPS6KB2 SCAMP3 SCD SCN5A SCNN1A SCNN1B SCNN1G SENP2 SERPINF1 SGK1 SGK2 SIVA1 SLC7A7 SMAD2 SMAD3 SMAD7 SNCA SPAG8 SRMS STAC STK40 TAF1B TARBP2 TBC1D7 TCEAL2 TGFB1I1 TMA16 TMEM55A TRIM41 UBAC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2J2 UBE2K UBE2L3 UBE2N VDAC2 WIBG WNK1 WNK4 YWHAG YWHAZ YY1 ZADH2 ZAK ZC3HAV1L ZDHHC3
Entrez ID 5710 23327
HPRD ID 03386 05903
Ensembl ID ENSG00000159352 ENSG00000049759
Uniprot IDs P55036 Q5VWC4 B7Z2P9 B7Z6K0 F5H602 Q96PU5
PDB IDs 1P9C 1P9D 1UEL 1YX4 1YX5 1YX6 2KDE 2KDF 2LAJ 2LB2 2LTY 2NSQ 2ONI 3JVZ 3JW0
Enriched GO Terms of Interacting Partners?
Tagcloud ?
confirm  degradation  demonstrating  dominant  e3  exploited  extend  incorporated  interacting  interferring  ligase  mdm2  modulate  motifs  p53  participates  proteasomal  proteasome  recognition  rescue  rpn10  s5a  selectively  selectivity  stabilization  ubiquitin  ubiquitinated  uim  uims 
2cl  antihypertensive  cotransporter  defective  demonstrating  emerging  enac  exchanger  highlight  hypertension  interactor  interesting  liddle  ligase  makes  na  ncc  nephron  nhe3  nkcc2  originally  progress  salt  sensitive  thiazide  transporters  ubiquitin  ubiquitylates 
Tagcloud (Difference) ?
confirm  degradation  dominant  e3  exploited  extend  incorporated  interacting  interferring  mdm2  modulate  motifs  p53  participates  proteasomal  proteasome  recognition  rescue  rpn10  s5a  selectively  selectivity  stabilization  ubiquitinated  uim  uims 
2cl  antihypertensive  cotransporter  defective  emerging  enac  exchanger  highlight  hypertension  interactor  interesting  liddle  makes  na  ncc  nephron  nhe3  nkcc2  originally  progress  salt  sensitive  thiazide  transporters  ubiquitylates 
Tagcloud (Intersection) ?
demonstrating  ligase  ubiquitin