H1-4 and CBX1

Number of citations of the paper that reports this interaction (PubMedID 16127177)
0

Data Source:
HPRD (in vitro)

		H1-4	CBX1
Description		H1.4 linker histone, cluster member	chromobox 1
Image
GO Annotations	Cellular Component	Chromatin Nucleosome Euchromatin Heterochromatin Nucleus Chromosome	Chromosome, Centromeric Region Chromosome, Telomeric Region Chromatin Heterochromatin Female Pronucleus Male Pronucleus Nucleus Nucleoplasm Pericentric Heterochromatin Spindle Chromocenter Nuclear Body Site Of DNA Damage
	Molecular Function	DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding Structural Constituent Of Chromatin Chromatin DNA Binding Nucleosomal DNA Binding Histone Deacetylase Binding	Chromatin Binding Protein Binding Enzyme Binding Identical Protein Binding Histone Methyltransferase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Nucleosome Assembly Regulation Of Transcription By RNA Polymerase II Chromosome Condensation Negative Regulation Of DNA Recombination	DNA Damage Response Heterochromatin Formation Negative Regulation Of DNA-templated Transcription
Pathways		Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)	HCMV Early Events
Drugs		Copper
Diseases
GWAS			Aspartate aminotransferase levels ( 33547301) Body mass index ( 20935630 26426971) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Generalized epilepsy ( 22949513)
Interacting Genes		10 interacting genes: CBX1 CBX3 CBX5 FOXP1 IL7R IRAK4 OGT PDE4B PRKCA RBFOX2	34 interacting genes: ABI3BP ARL5A ATXN7L2 BAHD1 BARD1 BRCA1 CBX3 CBX5 CHAF1A DNMT1 DNMT3A DNMT3B EMSY H1-4 H3-4 H3C1 H3C3 HECW2 HSPB1 KLF11 LNX1 LRIF1 NR2F6 PCNA PIM1 RPL12 SP100 SUV39H1 TRIM24 TRIM28 UCHL1 VHL VTN ZNF280C
Entrez ID		3008	10951
HPRD ID		07513	05149
Ensembl ID		ENSG00000168298	ENSG00000108468
Uniprot IDs		A3R0T8 P10412	P83916 Q6IBN6
PDB IDs		3TZD 5JJZ 6H8P 7K5Y 7K63 7PET 7PEU 7PEX 7PEZ 7PF0 7PF2 7PF3 7PF5 7PF6 7PFA 7PFC 7PFD 7PFE 7PFT 7PFU 7PFV 7PFW 7PFX 8H1T 8VG2 9DDE	2FMM 3F2U 3Q6S 5T1G 6D07 6D08
Enriched GO Terms of Interacting Partners?		Pericentric Heterochromatin Site Of DNA Damage Heterochromatin Negative Regulation Of Gene Expression Positive Regulation Of Smooth Muscle Cell Proliferation Chromocenter Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Stress Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Chromatin Organization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Metabolic Process Heterochromatin Formation Histone Methyltransferase Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Hemopoiesis Negative Regulation Of Gene Expression, Epigenetic Chromosome, Centromeric Region Chromosome, Telomeric Region Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Immune System Process Negative Regulation Of Lymphocyte Apoptotic Process Nucleoplasm Negative Regulation Of Metabolic Process Response To Ketone Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Regulation Of Muscle System Process Chromatin Remodeling Epigenetic Regulation Of Gene Expression Negative Regulation Of Leukocyte Apoptotic Process Regulation Of Metabolic Process Regulation Of Lymphocyte Apoptotic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Neutrophil Migration Response To Lipid Regulation Of Cardiac Muscle Hypertrophy DNA Damage Response Regulation Of RNA Metabolic Process Leukocyte Homeostasis Regulation Of Primary Metabolic Process Regulation Of Immune System Process Interleukin-7 Receptor Activity	Chromatin Organization Heterochromatin Chromatin Remodeling Epigenetic Regulation Of Gene Expression Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA (cytosine-5-)-methyltransferase Activity Nucleoplasm Chromatin Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Euchromatin Chromo Shadow Domain Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Epigenetic Programming Of Gene Expression Negative Regulation Of Biosynthetic Process Ubiquitin-protein Transferase Activity Chromosome Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Chromosome, Telomeric Region Regulation Of Primary Metabolic Process DNA Damage Response Nucleosome Assembly Histone H2AK127 Ubiquitin Ligase Activity Nucleus Histone H2AK129 Ubiquitin Ligase Activity Regulation Of Macromolecule Metabolic Process BRCA1-BARD1 Complex Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Regulation Of Metabolic Process Nucleosome Organization DNA Binding Cellular Response To Stress DNA-methyltransferase Activity BRCA1-B Complex Cellular Response To Bisphenol A Structural Constituent Of Chromatin Pericentric Heterochromatin Post-translational Protein Modification Protein-DNA Complex Assembly
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