HIST1H1E and IRAK4

Number of citations of the paper that reports this interaction (PMID 15927069)
0

Data Source:
BioGRID (enzymatic study)

		HIST1H1E	IRAK4
Gene Name		histone cluster 1, H1e	interleukin-1 receptor-associated kinase 4
Image
Gene Ontology Annotations	Cellular Component	Nucleosome Nucleus Nuclear Heterochromatin Extracellular Vesicular Exosome	Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Endosome Membrane
	Molecular Function	Protein Binding Chromatin DNA Binding Poly(A) RNA Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Interleukin-1 Receptor Binding Protein Binding ATP Binding
	Biological Process	Nucleosome Assembly Nucleosome Positioning	Cytokine Production Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation JNK Cascade Cytokine-mediated Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Smooth Muscle Cell Proliferation
Pathways		DNA Damage/Telomere Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Activation of DNA fragmentation factor Apoptosis induced DNA fragmentation Cellular Senescence Programmed Cell Death Apoptotic execution phase	Toll Like Receptor 7/8 (TLR7/8) Cascade Cytokine Signaling in Immune system Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Signaling by Interleukins Toll-Like Receptors Cascades MyD88 cascade initiated on plasma membrane Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 5 (TLR5) Cascade Toll Like Receptor 4 (TLR4) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Interleukin-1 signaling Toll Like Receptor 9 (TLR9) Cascade TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Innate Immune System
Drugs
Diseases
GWAS			Immune reponse to smallpox (secreted TNF-alpha) ( 22610502)
Protein-Protein Interactions		6 interactors: CBX1 CBX3 CBX5 IL7R IRAK4 PRKCA	18 interactors: ARNT EIF4EBP1 HIST1H1A HIST1H1B HIST1H1C HIST1H1D HIST1H1E HIST1H1T IRAK1 MBP MYD88 PELI1 PELI2 PELI3 TBPL1 TICAM2 TIRAP TRAF6
Entrez ID		3008	51135
HPRD ID		07513	06051
Ensembl ID		ENSG00000168298	ENSG00000198001
Uniprot IDs		A3R0T8 P10412	B2RAP9 B4E359 Q69FE3 Q9NWZ3
PDB IDs		3TZD	2NRU 2NRY 2O8Y 2OIB 2OIC 2OID 3MOP
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Biosynthetic Process Positive Regulation Of Dense Core Granule Biogenesis Response To Cytokine Interleukin-7-mediated Signaling Pathway Histone H3-T6 Phosphorylation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Immune System Process Negative Regulation Of T Cell Mediated Cytotoxicity Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Negative Regulation Of Glucose Import Immune Response Regulation Of Immune System Process Positive Regulation Of Macrophage Differentiation Negative Regulation Of Gene Expression Desmosome Organization Negative Regulation Of T Cell Mediated Immunity Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Lymph Node Development Positive Regulation Of T Cell Differentiation In Thymus Regulation Of Platelet Aggregation Negative Regulation Of Glucose Transport Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Blood Coagulation Hemostasis Positive Regulation Of Blood Vessel Endothelial Cell Migration Cytokine-mediated Signaling Pathway Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Regulation Of Cell Activation Negative Regulation Of Lyase Activity Regulation Of Rhodopsin Mediated Signaling Pathway Negative Regulation Of CAMP Biosynthetic Process Activation Of Adenylate Cyclase Activity Regulation Of Cardiac Muscle Hypertrophy Rhodopsin Mediated Signaling Pathway Regulation Of Platelet Activation Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Positive Chemotaxis Negative Regulation Of CAMP Metabolic Process Regulation Of The Force Of Heart Contraction Cellular Response To Organic Substance	Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Toll Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Regulation Of I-kappaB Kinase/NF-kappaB Signaling Nucleosome Assembly Regulation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Chromatin Assembly Nucleosome Organization Toll-like Receptor 9 Signaling Pathway Response To Bacterium Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Regulation Of Cytokine Production DNA Packaging Positive Regulation Of Cytokine Production Positive Regulation Of Immune System Process Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Nucleosome Positioning Response To Other Organism Immune Response-regulating Signaling Pathway Response To Biotic Stimulus DNA Conformation Change Positive Regulation Of Intracellular Signal Transduction Response To Lipopolysaccharide Positive Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Signal Transduction Cellular Response To Molecule Of Bacterial Origin Response To Molecule Of Bacterial Origin Regulation Of Immune System Process Defense Response Positive Regulation Of Interleukin-6 Production Positive Regulation Of Immune Response Protein Complex Assembly Regulation Of Protein Metabolic Process Regulation Of Interleukin-6 Production Innate Immune Response Positive Regulation Of Protein Metabolic Process Positive Regulation Of Lymphocyte Proliferation Response To Lipid
Tagcloud ?		abundance arrest bax bcl beneficial calcitriol candidates changing cyclins d3 eif2ak2 endometrial g0 hint2 identifies immortalized investigates oncogenesis p27 preventing progesterone proteomics prove stranded triad upregulate validation	curated degeneracy degenerative districts dysbiosis emerge experimentally gi gut interactomes microbiome mtx multi nitrogenous omic pathogens picture ppi properly recollects recommendation run screens silico simulation synovial topological usage warn
Tagcloud (Difference) ?		abundance arrest bax bcl beneficial calcitriol candidates changing cyclins d3 eif2ak2 endometrial g0 hint2 identifies immortalized investigates oncogenesis p27 preventing progesterone proteomics prove stranded triad upregulate validation	curated degeneracy degenerative districts dysbiosis emerge experimentally gi gut interactomes microbiome mtx multi nitrogenous omic pathogens picture ppi properly recollects recommendation run screens silico simulation synovial topological usage warn
Tagcloud (Intersection) ?