ERO1A and LHX4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ERO1A	LHX4
Description		endoplasmic reticulum oxidoreductase 1 alpha	LIM homeobox 4
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Golgi Apparatus Golgi Lumen Membrane Dendrite Cell Projection Intracellular Membrane-bounded Organelle	Chromatin Nucleus
	Molecular Function	Protein Binding Protein-disulfide Reductase Activity Oxidoreductase Activity Thiol Oxidase Activity FAD Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Methyl-CpG Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Folding Apoptotic Process Response To Oxidative Stress Transforming Growth Factor Beta Receptor Signaling Pathway Skeletal Muscle Tissue Development Response To Temperature Stimulus L-ascorbic Acid Metabolic Process Extracellular Matrix Organization Collagen Fibril Organization Endoplasmic Reticulum Unfolded Protein Response Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Protein Modification Process Cell Redox Homeostasis Brown Fat Cell Differentiation Release Of Sequestered Calcium Ion Into Cytosol Protein Maturation Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Hypoxia	Placenta Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Motor Neuron Axon Guidance Animal Organ Morphogenesis Medial Motor Column Neuron Differentiation Neuron Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Detoxification of Reactive Oxygen Species	Regulation of expression of SLITs and ROBOs
Drugs
Diseases			Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Heel bone mineral density ( 30598549) Urine 6-bromotryptophan levels in chronic kidney disease ( 32572055)	Refractive error ( 32231278)
Interacting Genes		14 interacting genes: APPBP2 EBF1 ERP44 GPX7 GPX8 GRSF1 LHX4 LINC01554 OGT P4HB PDIA3 PDILT PELI2 RHOU	54 interacting genes: ADAMTSL4 ARL2 AXIN1 BANP BOD1L2 CDK3 CENPS-CORT CHCHD2 CORO1B DCAF10 DHRS1 DNAJB13 ERO1A FDX2 GOLGA2 HNF1B HOXC5 IFT172 IKZF1 INO80B KLHL38 KRT38 KRT40 LDB2 LONRF1 MAPRE3 MRS2 MYOZ1 NFIC NFIX NRF1 ORC6 PARP11 POU1F1 QRICH1 SCAND1 SH2D1A SNRNP25 SNRPA SSX1 TCAP TCF4 TP53BP2 TRAPPC6A TRMT11 TSEN54 TSTD2 TXNDC5 UBQLN1 USP2 WASHC3 ZBTB2 ZNF354C ZNF76
Entrez ID		30001	89884
HPRD ID		13278	03686
Ensembl ID		ENSG00000197930	ENSG00000121454
Uniprot IDs		Q96HE7	A0A0S2Z5S4 Q969G2
PDB IDs		3AHQ 3AHR	5HOD
Enriched GO Terms of Interacting Partners?		Protein Disulfide Isomerase Activity Endoplasmic Reticulum Lumen Protein Folding Protein Folding In Endoplasmic Reticulum Cellular Response To Interleukin-7 Response To Interleukin-7 Cul2-RING Ubiquitin Ligase Complex Glutathione Peroxidase Activity Protein-disulfide Reductase Activity Peroxidase Activity Isomerase Activity Transport Of Viral Material Towards Nucleus Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Response To Endoplasmic Reticulum Stress
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