RHOD and BMPR1B

Number of citations of the paper that reports this interaction (PubMedID 15761153)
0

Data Source:
HPRD (in vivo)

		RHOD	BMPR1B
Description		ras homolog family member D	bone morphogenetic protein receptor type 1B
Image
GO Annotations	Cellular Component	Golgi Membrane Mitochondrial Outer Membrane Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Cell Projection	Plasma Membrane Membrane Dendrite Neuronal Cell Body Receptor Complex HFE-transferrin Receptor Complex
	Molecular Function	Nucleotide Binding GTPase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Protein Kinase Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transmembrane Signaling Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Kinase Activity Transferase Activity BMP Binding SMAD Binding Metal Ion Binding BMP Receptor Activity
	Biological Process	Protein Targeting Actin Filament Organization Small GTPase-mediated Signal Transduction Rho Protein Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway Cell Projection Assembly Lamellipodium Assembly Actin Filament Polymerization Positive Regulation Of Cell Migration Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Adhesion Focal Adhesion Assembly Actin Filament Bundle Assembly Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Focal Adhesion Assembly Response To Fibroblast Growth Factor	Cartilage Condensation Ovarian Cumulus Expansion Osteoblast Differentiation Eye Development Chondrocyte Differentiation Chondrocyte Development Inflammatory Response Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Dorsal/ventral Pattern Formation Positive Regulation Of Gene Expression Central Nervous System Neuron Differentiation Cell Differentiation Proteoglycan Biosynthetic Process Positive Regulation Of Bone Mineralization BMP Signaling Pathway Retinal Ganglion Cell Axon Guidance Positive Regulation Of Chondrocyte Differentiation Ovulation Cycle Camera-type Eye Development Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cartilage Development Retina Development In Camera-type Eye Bone Development Endochondral Bone Morphogenesis Positive Regulation Of Cartilage Development Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Chondrocyte Proliferation
Pathways		RHO GTPases Activate Formins RHOD GTPase cycle	Signaling by BMP
Drugs			Fostamatinib
Diseases			Acromesomelic dysplasia with genital anomalies Brachydactyly, including: type A; type B; type D; type E
GWAS		Height ( 20881960 25282103) Hip circumference adjusted for BMI ( 34021172) Waist circumference adjusted for body mass index ( 34021172)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Attention deficit hyperactivity disorder ( 20732626) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778 33020668) Diverticular disease ( 30177863) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 30598549) Hen's egg allergy ( 29051540) Maximum stenosis ( 32469969) Opioid dependence (time to event) ( 34124712) Polycystic ovary syndrome (reproductive subtype) ( 32574161) Prepulse inhibition of the startle response ( 31596458) Schizophrenia ( 30470734) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969) Systolic blood pressure ( 30578418 30224653) Waist-hip ratio ( 28552196)
Interacting Genes		13 interacting genes: ACVR1 ADCK5 ADRB2 ANKFY1 BMPR1B DIAPH2 HRAS IHH PLXNA1 SMAD2 SMAD4 SMURF2 TGFBR1	64 interacting genes: AMHR2 APP ARHGEF6 BAMBI BMP15 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR2 CDK14 CDK4 CHN1 DCAF12 DCAF6 DCAF7 FANCL GDF5 GDF6 GDF9 KLHL1 LZTR1 NKIRAS1 OTUB1 OXSR1 PAK1 PLEKHB1 POMK PPP2CA PPP3CC RAB25 RAB38 RAB6B RAN RAP2A RASD2 RASL12 RHEBL1 RHOD RHOJ RPS27A RRAS2 SASH3 SH3KBP1 SMAD6 SMAD7 SNX6 SOCS6 SQSTM1 SRGAP1 STAMBP STK35 STUB1 TGFBR1 TNNT1 TRAF6 TTC17 TTC27 UBA52 UBE2Z UBXN1 USP45 VEPH1
Entrez ID		29984	658
HPRD ID		05776	04457
Ensembl ID		ENSG00000173156	ENSG00000138696
Uniprot IDs		E9PIG5 O00212	A8KAE3 O00238
PDB IDs		2J1L 7KDC	3MDY
Enriched GO Terms of Interacting Partners?		SMAD Binding Transforming Growth Factor Beta Receptor Activity, Type I Activin Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Fate Commitment Pattern Specification Process Positive Regulation Of Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Tissue Morphogenesis I-SMAD Binding Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling In Utero Embryonic Development Chordate Embryonic Development Transforming Growth Factor Beta Receptor Signaling Pathway Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Positive Regulation Of Developmental Process Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regionalization Animal Organ Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Cellular Response To BMP Stimulus Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Responsive Factor Complex Regulation Of Ossification Osteoblast Differentiation Ameboidal-type Cell Migration Anatomical Structure Morphogenesis Response To Growth Factor Neuron Fate Commitment Ventricular Septum Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Enzyme-linked Receptor Protein Signaling Pathway Developmental Growth Gastrulation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Biomineral Tissue Development Tissue Development Regulation Of Chondrocyte Differentiation Positive Regulation Of Ossification Mesoderm Development Embryonic Morphogenesis Activin Receptor Complex	Regulation Of SMAD Protein Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Cartilage Development Response To Growth Factor Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cartilage Development Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Signal Transduction Cellular Response To BMP Stimulus GTPase Activity Cell Surface Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling GTP Binding Positive Regulation Of Bone Mineralization Cardiac Septum Morphogenesis Ubiquitin Protein Ligase Binding Regulation Of Ossification Nucleotide Binding Positive Regulation Of Biomineral Tissue Development Regulation Of Chondrocyte Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Ossification Transmembrane Receptor Protein Serine/threonine Kinase Activity Intracellular Signaling Cassette Regulation Of Osteoblast Differentiation Mesenchyme Development BMP Receptor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Growth Factor Activity Negative Regulation Of Signal Transduction Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Motility Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Locomotion Intracellular Signal Transduction Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Signaling Negative Regulation Of Cell Communication Post-translational Protein Modification Regulation Of Cell Migration
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