RHOD and DIAPH2

Number of citations of the paper that reports this interaction (PMID 12577064)
50

Data Source:
HPRD (in vivo, in vitro)

		RHOD	DIAPH2
Gene Name		ras homolog family member D	diaphanous-related formin 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Early Endosome Cytosol Plasma Membrane	Nucleolus Mitochondrion Early Endosome Golgi Apparatus Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	GTPase Activity GTP Binding Protein Kinase Binding	Actin Binding Receptor Binding Rho GTPase Binding
	Biological Process	Protein Targeting Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Metabolic Process Lamellipodium Assembly Positive Regulation Of Cell Migration Positive Regulation Of Cell Adhesion Focal Adhesion Assembly Actin Filament Bundle Assembly Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Focal Adhesion Assembly Regulation Of Actin Cytoskeleton Reorganization	Cytokinesis Multicellular Organismal Development Female Gamete Generation Actin Filament Polymerization Oogenesis
Pathways		Rho GTPase cycle Signaling by Rho GTPases
Drugs
Diseases
GWAS		Height ( 20881960)
Protein-Protein Interactions		14 interactors: ACVR1 ADCK5 ADRB2 ANKFY1 ARHGAP29 BMPR1B DIAPH2 HRAS IHH PLXNA1 SMAD2 SMAD4 SMURF2 TGFBR1	6 interactors: APBB1 CDC42 CENPA NCKIPSD RHOD TCERG1
Entrez ID		29984	1730
HPRD ID		05776	02117
Ensembl ID		ENSG00000173156	ENSG00000147202
Uniprot IDs		E9PIG5 O00212	O60879 Q17R91
PDB IDs		2J1L
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Organ Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta BMP Signaling Pathway Cell Development Pattern Specification Process Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Fate Commitment Activin Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signaling Cell Surface Receptor Signaling Pathway Tissue Morphogenesis Negative Regulation Of Cell Proliferation Tissue Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Bone Mineralization Cell Morphogenesis Involved In Differentiation Positive Regulation Of Biomineral Tissue Development Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Epithelial To Mesenchymal Transition Tube Morphogenesis Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Transcription, DNA-templated Mesenchyme Development Endocardial Cell Differentiation Branching Morphogenesis Of An Epithelial Tube Heart Morphogenesis In Utero Embryonic Development Morphogenesis Of An Epithelium Heart Development Endothelial Cell Activation Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Stem Cell Development Regulation Of Bone Mineralization Positive Regulation Of Gene Expression Signal Transduction Germ Cell Development	Cytoskeleton Organization Actin Filament Bundle Assembly Cellular Protein Localization Adherens Junction Organization Organelle Organization Negative Regulation Of Thymidylate Synthase Biosynthetic Process Positive Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of DNA Metabolic Process Protein Localization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Establishment Of Localization In Cell Actin Filament Branching Submandibular Salivary Gland Formation Establishment Or Maintenance Of Cell Polarity Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Synapse Structural Plasticity Regulation Of Cell-substrate Adhesion Cell-cell Junction Organization Cellular Localization Establishment Of Golgi Localization Positive Regulation Of Metalloenzyme Activity Phagocytosis Fc Receptor Signaling Pathway Cell Projection Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Neuron Fate Determination Epithelial-mesenchymal Cell Signaling Cell Projection Assembly Regulation Of Protein Heterodimerization Activity Actin Filament Organization Keratinocyte Development Regulation Of Synapse Structural Plasticity Establishment Of Organelle Localization Protein Localization To Chromosome, Centromeric Region Positive Regulation Of Pseudopodium Assembly Nuclear Migration Cardiac Conduction System Development Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Golgi Localization Axon Guidance Filopodium Assembly Organelle Localization Protein Targeting Intracellular Transport Hair Follicle Placode Formation Macrophage Differentiation NLS-bearing Protein Import Into Nucleus
Tagcloud ?		10nm 130nm 400nm 500ms 50nm 5x100hz bapta brevis buffering carbonylcyanide ctrl digitorum electrically electroporation fccp fdb flexor fluo footpads mag mfn2 mitofusin myoplasmic sarcomere tetani tetanic tethers transients trifluoromethoxyphenylhydrazone
Tagcloud (Difference) ?		10nm 130nm 400nm 500ms 50nm 5x100hz bapta brevis buffering carbonylcyanide ctrl digitorum electrically electroporation fccp fdb flexor fluo footpads mag mfn2 mitofusin myoplasmic sarcomere tetani tetanic tethers transients trifluoromethoxyphenylhydrazone
Tagcloud (Intersection) ?