RHOD and SMURF2

Number of citations of the paper that reports this interaction (PubMedID 15761153)
0

Data Source:
HPRD (in vivo)

		RHOD	SMURF2
Description		ras homolog family member D	SMAD specific E3 ubiquitin protein ligase 2
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GO Annotations	Cellular Component	Golgi Membrane Mitochondrial Outer Membrane Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Cell Projection	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Speck Membrane Raft
	Molecular Function	Nucleotide Binding GTPase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Protein Kinase Binding	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Identical Protein Binding SMAD Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Targeting Actin Filament Organization Small GTPase-mediated Signal Transduction Rho Protein Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway Cell Projection Assembly Lamellipodium Assembly Actin Filament Polymerization Positive Regulation Of Cell Migration Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Adhesion Focal Adhesion Assembly Actin Filament Bundle Assembly Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Focal Adhesion Assembly Response To Fibroblast Growth Factor	Negative Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Trophoblast Cell Migration
Pathways		RHO GTPases Activate Formins RHOD GTPase cycle	Signaling by BMP Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity Asymmetric localization of PCP proteins Degradation of AXIN Hedgehog 'on' state Hedgehog 'on' state Ub-specific processing proteases Regulation of RUNX3 expression and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Height ( 20881960 25282103) Hip circumference adjusted for BMI ( 34021172) Waist circumference adjusted for body mass index ( 34021172)	Cardiac troponin-I levels ( 31014085) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Joint mobility (Beighton score) ( 27182965) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Periodontitis (Mean PAL) ( 24024966)
Interacting Genes		13 interacting genes: ACVR1 ADCK5 ADRB2 ANKFY1 BMPR1B DIAPH2 HRAS IHH PLXNA1 SMAD2 SMAD4 SMURF2 TGFBR1	94 interacting genes: ABRAXAS2 ACBD3 ACOX3 ADAR AIMP2 ANAPC5 ARHGAP5 ASH2L AXIN1 BTRC CANX CNKSR2 CUEDC1 DAB2 DAZAP2 DGCR2 DSCR9 EGFR EPHA1 ERBB2 FKBP4 FLNB FUBP1 GNG2 HDGFL3 ING2 IRF3 IRF8 ITGB1BP1 KLF5 LAPTM5 LATS1 LITATS1 LMNA MAVS NEK6 NKIRAS1 NRAS PARP1 PDE4B PPID PRICKLE1 PRICKLE2 RAB13 RAB14 RAB17 RAB22A RAB25 RAN RAP1B RASD2 RASL12 RHOD RLIM RNF11 RNF111 RNF2 RPS27A RRAS2 RTN4IP1 RUNX2 RUNX3 SF3A2 SKIL SMAD1 SMAD2 SMAD3 SMAD5 SMAD6 SMAD7 SMAP1 SNCA SNRNP70 SOCS6 SPART SRSF4 TFPI2 TGFBR1 TMEM139 TNPO3 TOP2A TRAF2 TRAF4 TRIM28 TSSK4 TXNIP UBC UBE2D2 UBE2D3 UBE2L3 USP15 XPO1 YY1 ZBTB44
Entrez ID		29984	64750
HPRD ID		05776	06901
Ensembl ID		ENSG00000173156	ENSG00000108854
Uniprot IDs		E9PIG5 O00212	Q96DE7 Q9HAU4
PDB IDs		2J1L 7KDC	1ZVD 2DJY 2JQZ 2KXQ 2LTZ 6FX4 7M3Q
Enriched GO Terms of Interacting Partners?		SMAD Binding Transforming Growth Factor Beta Receptor Activity, Type I Activin Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Fate Commitment Pattern Specification Process Positive Regulation Of Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Tissue Morphogenesis I-SMAD Binding Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling In Utero Embryonic Development Chordate Embryonic Development Transforming Growth Factor Beta Receptor Signaling Pathway Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Positive Regulation Of Developmental Process Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regionalization Animal Organ Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Cellular Response To BMP Stimulus Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Responsive Factor Complex Regulation Of Ossification Osteoblast Differentiation Ameboidal-type Cell Migration Anatomical Structure Morphogenesis Response To Growth Factor Neuron Fate Commitment Ventricular Septum Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Enzyme-linked Receptor Protein Signaling Pathway Developmental Growth Gastrulation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Biomineral Tissue Development Tissue Development Regulation Of Chondrocyte Differentiation Positive Regulation Of Ossification Mesoderm Development Embryonic Morphogenesis Activin Receptor Complex	Ubiquitin Protein Ligase Binding I-SMAD Binding Heteromeric SMAD Protein Complex Response To Growth Factor Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Protein Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Binding Enzyme-linked Receptor Protein Signaling Pathway Protein-containing Complex Negative Regulation Of RNA Metabolic Process GTPase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Nucleobase-containing Compound Metabolic Process GDP Binding Negative Regulation Of Transcription By RNA Polymerase II GTP Binding Nucleoplasm Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Cytosol Negative Regulation Of Signal Transduction SMAD Protein Complex Cell Surface Receptor Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Cell Development Regulation Of RNA Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Transcription Regulator Complex Ureteric Bud Development Negative Regulation Of Macromolecule Metabolic Process Post-translational Protein Modification Response To Transforming Growth Factor Beta Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Osteoblast Fate Commitment Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Mesonephric Tubule Development Cellular Developmental Process Intracellular Signal Transduction Mesonephric Epithelium Development Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process R-SMAD Binding
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