GYS1 and KLF1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GYS1	KLF1
Description		glycogen synthase 1	KLF transcription factor 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Inclusion Body	Chromatin Nucleus Nucleoplasm
	Molecular Function	Catalytic Activity Alpha-1,4-glucan Glucosyltransferase (UDP-glucose Donor) Activity Protein Binding D-glucose Binding Transferase Activity Glycosyltransferase Activity Glycogen Synthase Activity, Transferring Glucose-1-phosphate	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Ubiquitin Binding Metal Ion Binding
	Biological Process	Glycogen Metabolic Process Glycogen Biosynthetic Process Heart Development	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Erythrocyte Differentiation Protein Destabilization Positive Regulation Of DNA-templated Transcription Maternal Process Involved In Female Pregnancy Cellular Response To Endothelin
Pathways		Glycogen synthesis Myoclonic epilepsy of Lafora Glycogen storage disease type XV (GYG1) Glycogen storage disease type 0 (muscle GYS1)
Drugs
Diseases		Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)	Congenital dyserythropoietic anemias (CDAs)
GWAS			Clozapine-induced agranulocytosis ( 25187353) High light scatter reticulocyte count ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean corpuscular volume ( 29403010 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 27863252 32888494) Red cell distribution width ( 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		43 interacting genes: AIMP2 APP BEND7 CCDC33 CDCA8 CLVS2 CRX CSNK2A1 EFHC2 FAM228A GSK3B GYG1 GYG2 HOXB6 HOXC8 IHO1 INCA1 KATNBL1 KLF1 KLF4 MAPKAPK5 MEOX1 NDUFB7 NHLRC1 PCYT1A PINX1 PLAGL2 PNMA5 PRKACA RBM48 SNIP1 SORBS3 SUMO2 TFAP2D TLE5 WASHC1 ZBTB33 ZNF212 ZNF326 ZNF474 ZNF552 ZNF620 ZNF774	32 interacting genes: ARID1A C1QBP CCDC57 CREBBP CSNK2A1 CSNK2A2 DVL3 EFEMP2 EP300 FLI1 GYS1 HDAC1 HNRNPF HNRNPK MKRN3 PATZ1 PCBP1 PRKACA PRR3 RBM10 RBM4B RBPMS2 SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCE1 SNRPC TIAL1 TLE5 VPS37C
Entrez ID		2997	10661
HPRD ID		00721	07197
Ensembl ID		ENSG00000104812	ENSG00000105610
Uniprot IDs		P13807	Q13351
PDB IDs		7Q0B 7Q0S 7Q12 7Q13 7ZBN 8CVX 8CVY 8CVZ	2L2I 2MBH 2N23
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Glycogenin Glucosyltransferase Activity Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Glycogen Biosynthetic Process Glycogen Metabolic Process Regulation Of RNA Metabolic Process DNA Binding Polysaccharide Biosynthetic Process Protein Binding Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Energy Reserve Metabolic Process Polysaccharide Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Energy Derivation By Oxidation Of Organic Compounds Regulation Of Protein Ubiquitination Regulation Of Protein Metabolic Process Cellular Response To Endothelin Positive Regulation Of Apoptotic Process Regulation Of Post-translational Protein Modification Response To Endothelin Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Wnt Signaling Pathway RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Neuron Apoptotic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Laminar Fluid Shear Stress Regulation Of Cell Cycle Generation Of Precursor Metabolites And Energy Positive Regulation Of Protein Export From Nucleus	NpBAF Complex NBAF Complex Nucleosome Disassembly Protein-DNA Complex Disassembly Regulation Of Nucleotide-excision Repair SWI/SNF Complex Brahma Complex Regulation Of Double-strand Break Repair RSC-type Complex Regulation Of G0 To G1 Transition Regulation Of Chromosome Segregation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Stem Cell Population Maintenance BBAF Complex Regulation Of DNA Repair Positive Regulation Of Double-strand Break Repair Positive Regulation Of T Cell Differentiation Regulation Of Stem Cell Population Maintenance Nucleosomal DNA Binding Regulation Of Myoblast Differentiation Regulation Of Cellular Response To Stress Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of DNA Repair Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Transcription By RNA Polymerase II Regulation Of Sister Chromatid Segregation Regulation Of T Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coactivator Activity Chromatin Positive Regulation Of Leukocyte Differentiation Regulation Of RNA Metabolic Process Nucleosome Organization Regulation Of Lymphocyte Differentiation Nucleoplasm Protein-containing Complex Disassembly Regulation Of Primary Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of Cell Adhesion Chromatin Remodeling Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Biosynthetic Process Positive Regulation Of T Cell Activation Regulation Of Gene Expression Regulation Of DNA-templated Transcription Positive Regulation Of DNA Metabolic Process Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle G1/S Phase Transition
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