GYS1 and ZNF326

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GYS1	ZNF326
Description		glycogen synthase 1	zinc finger protein 326
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Inclusion Body	Nucleus Nucleoplasm Nuclear Matrix DBIRD Complex
	Molecular Function	Catalytic Activity Alpha-1,4-glucan Glucosyltransferase (UDP-glucose Donor) Activity Protein Binding D-glucose Binding Transferase Activity Glycosyltransferase Activity Glycogen Synthase Activity, Transferring Glucose-1-phosphate	RNA Polymerase II Complex Binding DNA Binding RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Glycogen Metabolic Process Glycogen Biosynthetic Process Heart Development	MRNA Processing RNA Splicing Regulation Of DNA-templated Transcription Elongation Regulation Of RNA Splicing
Pathways		Glycogen synthesis Myoclonic epilepsy of Lafora Glycogen storage disease type XV (GYG1) Glycogen storage disease type 0 (muscle GYS1)
Drugs
Diseases		Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS			Brain structure (hippocampal volume) ( 20197096) Major depressive disorder ( 27479909) Obsessive-compulsive symptoms ( 26859814) Thiopurine-induced digestive symptoms in inflammatory bowel disease ( 29923122)
Interacting Genes		43 interacting genes: AIMP2 APP BEND7 CCDC33 CDCA8 CLVS2 CRX CSNK2A1 EFHC2 FAM228A GSK3B GYG1 GYG2 HOXB6 HOXC8 IHO1 INCA1 KATNBL1 KLF1 KLF4 MAPKAPK5 MEOX1 NDUFB7 NHLRC1 PCYT1A PINX1 PLAGL2 PNMA5 PRKACA RBM48 SNIP1 SORBS3 SUMO2 TFAP2D TLE5 WASHC1 ZBTB33 ZNF212 ZNF326 ZNF474 ZNF552 ZNF620 ZNF774	9 interacting genes: GEMIN4 GYS1 KHDRBS3 KPNA5 NCOA5 PTEN SLC26A4-AS1 SPTA1 VMAC
Entrez ID		2997	284695
HPRD ID		00721	15774
Ensembl ID		ENSG00000104812	ENSG00000162664
Uniprot IDs		P13807	A0A0A0MRN4 Q5BKZ1
PDB IDs		7Q0B 7Q0S 7Q12 7Q13 7ZBN 8CVX 8CVY 8CVZ
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Glycogenin Glucosyltransferase Activity Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Glycogen Biosynthetic Process Glycogen Metabolic Process Regulation Of RNA Metabolic Process DNA Binding Polysaccharide Biosynthetic Process Protein Binding Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Energy Reserve Metabolic Process Polysaccharide Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Energy Derivation By Oxidation Of Organic Compounds Regulation Of Protein Ubiquitination Regulation Of Protein Metabolic Process Cellular Response To Endothelin Positive Regulation Of Apoptotic Process Regulation Of Post-translational Protein Modification Response To Endothelin Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Wnt Signaling Pathway RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Neuron Apoptotic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Laminar Fluid Shear Stress Regulation Of Cell Cycle Generation Of Precursor Metabolites And Energy Positive Regulation Of Protein Export From Nucleus
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