KLF1 and PRR3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KLF1	PRR3
Description		KLF transcription factor 1	proline rich 3
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Ubiquitin Binding Metal Ion Binding	RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Erythrocyte Differentiation Protein Destabilization Positive Regulation Of DNA-templated Transcription Maternal Process Involved In Female Pregnancy Cellular Response To Endothelin
Pathways
Drugs
Diseases		Congenital dyserythropoietic anemias (CDAs)
GWAS		Clozapine-induced agranulocytosis ( 25187353) High light scatter reticulocyte count ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean corpuscular volume ( 29403010 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 27863252 32888494) Red cell distribution width ( 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)	Autism spectrum disorder or schizophrenia ( 28540026) Itch intensity from mosquito bite ( 28199695) Neuroticism ( 29255261)
Interacting Genes		32 interacting genes: ARID1A C1QBP CCDC57 CREBBP CSNK2A1 CSNK2A2 DVL3 EFEMP2 EP300 FLI1 GYS1 HDAC1 HNRNPF HNRNPK MKRN3 PATZ1 PCBP1 PRKACA PRR3 RBM10 RBM4B RBPMS2 SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCE1 SNRPC TIAL1 TLE5 VPS37C	25 interacting genes: APOBEC3C ASF1A BCL2L2-PABPN1 CCDC57 CLP1 DMRTB1 EXOSC8 HNRNPA0 KHDRBS2 KHDRBS3 KLF1 KRT31 KRTAP6-2 KRTAP6-3 MYPOP NXF1 PSMA3 RAMAC RBM3 RBMX RBMY1A1 RBMY1F RBMY1J SNRPA TLE5
Entrez ID		10661	80742
HPRD ID		07197	17915
Ensembl ID		ENSG00000105610	ENSG00000204576
Uniprot IDs		Q13351	B3KQA4 P79522 Q96QB9
PDB IDs		2L2I 2MBH 2N23
Enriched GO Terms of Interacting Partners?		NpBAF Complex NBAF Complex Nucleosome Disassembly Protein-DNA Complex Disassembly Regulation Of Nucleotide-excision Repair SWI/SNF Complex Brahma Complex Regulation Of Double-strand Break Repair RSC-type Complex Regulation Of G0 To G1 Transition Regulation Of Chromosome Segregation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Stem Cell Population Maintenance BBAF Complex Regulation Of DNA Repair Positive Regulation Of Double-strand Break Repair Positive Regulation Of T Cell Differentiation Regulation Of Stem Cell Population Maintenance Nucleosomal DNA Binding Regulation Of Myoblast Differentiation Regulation Of Cellular Response To Stress Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of DNA Repair Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Transcription By RNA Polymerase II Regulation Of Sister Chromatid Segregation Regulation Of T Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coactivator Activity Chromatin Positive Regulation Of Leukocyte Differentiation Regulation Of RNA Metabolic Process Nucleosome Organization Regulation Of Lymphocyte Differentiation Nucleoplasm Protein-containing Complex Disassembly Regulation Of Primary Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of Cell Adhesion Chromatin Remodeling Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Biosynthetic Process Positive Regulation Of T Cell Activation Regulation Of Gene Expression Regulation Of DNA-templated Transcription Positive Regulation Of DNA Metabolic Process Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle G1/S Phase Transition	Regulation Of MRNA Splicing, Via Spliceosome MRNA Processing MRNA Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing RNA Processing Nucleic Acid Binding Positive Regulation Of RNA Splicing Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process RNA Binding RNA Metabolic Process Spliceosomal Complex Nucleic Acid Metabolic Process MRNA Binding Positive Regulation Of MRNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Splicing Nucleus Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of RNA Metabolic Process Identical Protein Binding Regulation Of Gene Expression MRNA 3'-UTR AU-rich Region Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Positive Regulation Of Gene Expression Intermediate Filament ATP-dependent Polyribonucleotide 5'-hydroxyl-kinase Activity Polynucleotide 5'-hydroxyl-kinase Activity ATP-dependent Polynucleotide 5'-hydroxyl-kinase Activity MRNA Capping Enzyme Complex MRNA Cap Methyltransferase RNMT:RAMAC Complex RNA 5'-cap (guanine-N7)-methylation Regulation Of Macromolecule Metabolic Process Global Gene Silencing By MRNA Cleavage U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Supraspliceosomal Complex Keratinization
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