GYS1 and MAPKAPK5

Number of citations of the paper that reports this interaction (PMID 9628874)
65

Data Source:
HPRD (in vitro)

		GYS1	MAPKAPK5
Gene Name		glycogen synthase 1 (muscle)	mitogen-activated protein kinase-activated protein kinase 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Membrane Inclusion Body	Nucleoplasm Cytoplasm
	Molecular Function	Glycogen (starch) Synthase Activity Protein Binding Glucose Binding Protein Kinase Binding Glycogen Synthase Activity, Transferring Glucose-1-phosphate	P53 Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Carbohydrate Metabolic Process Glycogen Biosynthetic Process Glucose Metabolic Process Heart Development Pathogenesis Small Molecule Metabolic Process	MAPK Cascade Activation Of MAPK Activity Regulation Of Translation Signal Transduction Ras Protein Signal Transduction Negative Regulation Of TOR Signaling Protein Autophosphorylation Stress-induced Premature Senescence
Pathways		Glucose metabolism Glycogen synthesis Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates	Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: AIMP2 APP CCDC36 CSNK2A1 GSK3B GYG1 GYG2 MAPKAPK5 PRKACA	28 interactors: ATF2 CDCA8 EEF2K EIF4E EIF4EBP1 GYS1 HSPB1 HSPB2 JUN LSR MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK4 MAPK6 MAPK9 MBP MYH11 PLA2G4A RPL13 SRPK1 SRPK2 TAB1 TP53 ZNF282 ZNF576
Entrez ID		2997	8550
HPRD ID		00721	09467
Ensembl ID		ENSG00000104812	ENSG00000089022
Uniprot IDs		P13807	Q8IW41
PDB IDs
Enriched GO Terms of Interacting Partners?		Energy Reserve Metabolic Process Positive Regulation Of Protein Metabolic Process Glycogen Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Polysaccharide Metabolic Process Apoptotic Process Generation Of Precursor Metabolites And Energy Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Export From Nucleus Cell Death Death Positive Regulation Of Cellular Protein Metabolic Process Glucose Metabolic Process Regulation Of Protein Binding Glycogen Catabolic Process Carbohydrate Biosynthetic Process Regulation Of Protein Metabolic Process Polysaccharide Catabolic Process Protein Phosphorylation Chemotaxis Regulation Of Proteasomal Protein Catabolic Process Glycogen Biosynthetic Process Pathogenesis Hexose Metabolic Process Regulation Of Proteolysis Regulation Of Cardiac Muscle Hypertrophy Regulation Of Protein Export From Nucleus Cellular Carbohydrate Catabolic Process Cellular Carbohydrate Metabolic Process Regulation Of Protein Kinase Activity Monosaccharide Metabolic Process Regulation Of Binding Negative Regulation Of Catalytic Activity Cellular Polysaccharide Biosynthetic Process Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Polysaccharide Biosynthetic Process Regulation Of MAP Kinase Activity Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Phosphorylation Positive Regulation Of Metabolic Process Carbohydrate Metabolic Process Regulation Of Protein Catabolic Process Axon Guidance Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Protein Processing Regulation Of Mitotic Cell Cycle	MAPK Cascade Signal Transduction By Phosphorylation Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Phosphorylation Regulation Of Innate Immune Response Response To Organic Substance Response To Stress Gene Expression Cellular Response To Organic Substance Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Immune Response Protein Phosphorylation Signaling Phosphate-containing Compound Metabolic Process Cell Cycle Cell Communication Ras Protein Signal Transduction Innate Immune Response Signal Transduction Mitochondrion Organization Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Signaling Pathway Apoptotic Mitochondrial Changes Defense Response Response To Toxic Substance Cellular Response To Stimulus Response To Stimulus
Tagcloud ?		akt1 antidiabetic antiobesity extract fructose glut glut1 glut2 glut3 glut4 green gsk3b igf1 igf2 igf2r ins1 ins2 insr irs1 irs2 pik3cb pik3r1 shc1 slc2a1 slc2a2 slc2a3 slc2a4 sos1 tea	acids amino blot designated encodes erk gst homology identities jnk jun kinase light mitogen myosin northern novel nucleotide p38 phosphorylate phosphorylated recombinant sequence shares substrate wide
Tagcloud (Difference) ?		akt1 antidiabetic antiobesity extract fructose glut glut1 glut2 glut3 glut4 green gsk3b igf1 igf2 igf2r ins1 ins2 insr irs1 irs2 pik3cb pik3r1 shc1 slc2a1 slc2a2 slc2a3 slc2a4 sos1 tea	acids amino blot designated encodes erk gst homology identities jnk jun kinase light mitogen myosin northern novel nucleotide p38 phosphorylate phosphorylated recombinant sequence shares substrate wide
Tagcloud (Intersection) ?