KLF1 and FLI1

Number of citations of the paper that reports this interaction (PubMedID 12556498)
80

Data Source:
HPRD (in vitro)

		KLF1	FLI1
Description		KLF transcription factor 1	Fli-1 proto-oncogene, ETS transcription factor
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Chromatin Nucleus Nucleoplasm Cytosol Nuclear Body
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Ubiquitin Binding Metal Ion Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Erythrocyte Differentiation Protein Destabilization Positive Regulation Of DNA-templated Transcription Maternal Process Involved In Female Pregnancy Cellular Response To Endothelin	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Hemostasis Blood Circulation Animal Organ Morphogenesis Cell Differentiation Megakaryocyte Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways			Transcriptional regulation of granulopoiesis
Drugs
Diseases		Congenital dyserythropoietic anemias (CDAs)	Ewing's sarcoma
GWAS		Clozapine-induced agranulocytosis ( 25187353) High light scatter reticulocyte count ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean corpuscular volume ( 29403010 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 27863252 32888494) Red cell distribution width ( 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)	Albumin-globulin ratio ( 29403010) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Corneal astigmatism ( 30306274) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Digit length ratio ( 29659830) Digit length ratio (left hand) ( 29659830) Digit length ratio (right hand) ( 29659830) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Heel bone mineral density ( 30598549) Height ( 31562340 20881960) Hip circumference adjusted for BMI ( 34021172) Left ventricular obstructive tract defect (inherited effect) ( 28468790) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Myopia (pathological) ( 23049088) Non-albumin protein levels ( 29403010) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Refractive error ( 32231278) Rheumatoid arthritis ( 22446963) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 27399966 26502338) Type 1 diabetes ( 34012112 34127860) Vitiligo ( 27723757)
Interacting Genes		32 interacting genes: ARID1A C1QBP CCDC57 CREBBP CSNK2A1 CSNK2A2 DVL3 EFEMP2 EP300 FLI1 GYS1 HDAC1 HNRNPF HNRNPK MKRN3 PATZ1 PCBP1 PRKACA PRR3 RBM10 RBM4B RBPMS2 SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCE1 SNRPC TIAL1 TLE5 VPS37C	18 interacting genes: BRCA1 CTBP2 ELK1 ERG ETV6 EWSR1 GATA1 KLF1 PIAS1 PIAS2 PRKCD SIAH1 SMAD3 SMAD9 SOX30 SRF TDP2 UBE2I
Entrez ID		10661	2313
HPRD ID		07197	01901
Ensembl ID		ENSG00000105610	ENSG00000151702
Uniprot IDs		Q13351	Q01543
PDB IDs		2L2I 2MBH 2N23	1FLI 1X66 2YTU 5E8G 5E8I 5JVT 6VG2 6VG8 6VGD 9CP6 9MWY 9MX8 9MX9 9MXA
Enriched GO Terms of Interacting Partners?		NpBAF Complex NBAF Complex Nucleosome Disassembly Protein-DNA Complex Disassembly Regulation Of Nucleotide-excision Repair SWI/SNF Complex Brahma Complex Regulation Of Double-strand Break Repair RSC-type Complex Regulation Of G0 To G1 Transition Regulation Of Chromosome Segregation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Stem Cell Population Maintenance BBAF Complex Regulation Of DNA Repair Positive Regulation Of Double-strand Break Repair Positive Regulation Of T Cell Differentiation Regulation Of Stem Cell Population Maintenance Nucleosomal DNA Binding Regulation Of Myoblast Differentiation Regulation Of Cellular Response To Stress Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of DNA Repair Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Transcription By RNA Polymerase II Regulation Of Sister Chromatid Segregation Regulation Of T Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coactivator Activity Chromatin Positive Regulation Of Leukocyte Differentiation Regulation Of RNA Metabolic Process Nucleosome Organization Regulation Of Lymphocyte Differentiation Nucleoplasm Protein-containing Complex Disassembly Regulation Of Primary Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of Cell Adhesion Chromatin Remodeling Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Biosynthetic Process Positive Regulation Of T Cell Activation Regulation Of Gene Expression Regulation Of DNA-templated Transcription Positive Regulation Of DNA Metabolic Process Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle G1/S Phase Transition	Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA Binding Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Nucleus Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Cis-regulatory Region Binding Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cellular Developmental Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process SUMO Transferase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Biosynthetic Process SMAD Protein Signal Transduction Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Cell Differentiation PML Body Sequence-specific DNA Binding Negative Regulation Of Macromolecule Metabolic Process Transcription Coregulator Binding Cellular Response To Oxygen-containing Compound Negative Regulation Of Metabolic Process Protein Sumoylation SMAD Protein Complex Response To Hormone Heteromeric SMAD Protein Complex Developmental Process
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