KLF1 and SMARCA4

Number of citations of the paper that reports this interaction (PMID 11018012)
66

Data Source:
BioGRID (pull down)

		KLF1	SMARCA4
Gene Name		Kruppel-like factor 1 (erythroid)	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
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Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus	Nuclear Chromatin Heterochromatin Extracellular Space Nucleus Nucleoplasm Nuclear Euchromatin Perichromatin Fibrils Nucleolus Membrane SWI/SNF Complex Protein Complex NpBAF Complex NBAF Complex
	Molecular Function	Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Regulatory Region DNA Binding Metal Ion Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Transcription Coactivator Activity P53 Binding Transcription Coactivator Activity Transcription Corepressor Activity Helicase Activity Protein Binding ATP Binding DNA-dependent ATPase Activity Tat Protein Binding Nucleosomal DNA Binding Protein N-terminus Binding Androgen Receptor Binding DNA Polymerase Binding Lysine-acetylated Histone Binding
	Biological Process	In Utero Embryonic Development Liver Development Chromatin Remodeling Transcription, DNA-templated Erythrocyte Differentiation Embryonic Hemopoiesis Erythrocyte Maturation Positive Regulation Of Transcription, DNA-templated Cellular Response To Peptide	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Vasculogenesis Blastocyst Growth Blastocyst Hatching Liver Development Neural Retina Development Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Methylation-dependent Chromatin Silencing Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Glial Cell Fate Determination DNA Methylation On Cytosine Within A CG Sequence Stem Cell Maintenance Positive Regulation Of Wnt Signaling Pathway Extracellular Matrix Organization Keratinocyte Differentiation Negative Regulation Of Cell Growth Forebrain Development Hindbrain Development Embryonic Hindlimb Morphogenesis Aortic Smooth Muscle Cell Differentiation ATP-dependent Chromatin Remodeling Positive Regulation Of DNA Binding Positive Regulation By Host Of Viral Transcription Histone H3 Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Organ Morphogenesis Epidermis Morphogenesis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Definitive Erythrocyte Differentiation Heart Trabecula Formation Negative Regulation Of Androgen Receptor Signaling Pathway Lens Fiber Cell Development Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			Chromatin modifying enzymes Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer RMTs methylate histone arginines
Drugs
Diseases
GWAS			Coronary heart disease ( 21347282)
Protein-Protein Interactions		14 interactors: ARID1A CREBBP CSNK2A1 CSNK2A2 EP300 FLI1 HDAC1 PRKACA SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCE1	73 interactors: ACTB ACTL6A AHR AR ARID1A ARID1B ARID2 BRCA1 BRWD1 CARM1 CBX5 CCNE1 CDK19 CDK8 CDKN2A CDX2 CEBPA CEBPB CHD4 CHMP5 CIITA CREB1 CTNNB1 DPF3 ESR1 ETS2 FANCA GATA1 GMNN H2AFX H3F3A HIST1H3A HIST1H4F HIST2H2BE HIST2H3C HSF1 HSF4 IKZF1 KLF1 MBD3 MDM2 MED17 MED6 MKL1 MPHOSPH6 MPP6 MYC MYOCD NR3C1 NR4A2 PABPN1 PAX6 PBRM1 PHB RAP1A RB1 RBL1 RBL2 RELB RFXAP SIN3A SIN3B SMARCB1 SMARCC1 SMARCE1 SS18 SS18L1 STAT2 STAT3 STK11 TMF1 TP53 ZMYND11
Entrez ID		10661	6597
HPRD ID		07197	04459
Ensembl ID		ENSG00000105610	ENSG00000127616
Uniprot IDs		Q13351	A7E2E1 B3KNW7 P51532 Q9HBD4
PDB IDs		2L2I	2GRC 2H60 3UVD
Enriched GO Terms of Interacting Partners?		Nucleosome Disassembly Chromatin Modification ATP-dependent Chromatin Remodeling Chromatin Organization Chromatin Remodeling Chromosome Organization Nucleosome Organization Chromatin Assembly Or Disassembly Protein Complex Disassembly Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Positive Regulation Of Transcription, DNA-templated Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Developmental Process System Development Nervous System Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Interaction With Symbiont RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Positive Regulation By Host Of Viral Transcription Negative Regulation Of Cellular Metabolic Process Organelle Organization Regulation Of Viral Transcription RNA Metabolic Process Anatomical Structure Morphogenesis Regulation Of Metabolic Process Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryo Development Regulation Of Viral Process	Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromosome Organization Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Modification Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Organelle Organization Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Chromatin Remodeling Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Regulation Of Cellular Process Intracellular Steroid Hormone Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Anatomical Structure Development Developmental Process Chromatin Assembly Or Disassembly System Development Multicellular Organismal Development ATP-dependent Chromatin Remodeling
Tagcloud ?		acetylation active binds chromatin compromising contributing disappearance erythroid explore expressions facilitating forming gata generation globin interestingly k562 knockdown locus looping near occupancy stabilizing stably structure tal1 though transcribing unclear	abnormality arid1a coinactivation copyright fish frame harboring heterozygous infancy insights malignancies missense monoploid mrts pbrm1 protected remodeling reserved rhabdoid rights screened sense snf subunits swi trisomy truncating
Tagcloud (Difference) ?		acetylation active binds chromatin compromising contributing disappearance erythroid explore expressions facilitating forming gata generation globin interestingly k562 knockdown locus looping near occupancy stabilizing stably structure tal1 though transcribing unclear	abnormality arid1a coinactivation copyright fish frame harboring heterozygous infancy insights malignancies missense monoploid mrts pbrm1 protected remodeling reserved rhabdoid rights screened sense snf subunits swi trisomy truncating
Tagcloud (Intersection) ?