KLF1 and CCDC57

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KLF1	CCDC57
Description		KLF transcription factor 1	coiled-coil domain containing 57
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Cytoplasm Centrosome Centriole Spindle Cytoskeleton Spindle Microtubule Centriolar Satellite
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Ubiquitin Binding Metal Ion Binding	Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Erythrocyte Differentiation Protein Destabilization Positive Regulation Of DNA-templated Transcription Maternal Process Involved In Female Pregnancy Cellular Response To Endothelin	G2/M Transition Of Mitotic Cell Cycle Microtubule Nucleation Centriole Replication Positive Regulation Of Mitotic Cell Cycle Cilium Assembly
Pathways
Drugs
Diseases		Congenital dyserythropoietic anemias (CDAs)
GWAS		Clozapine-induced agranulocytosis ( 25187353) High light scatter reticulocyte count ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean corpuscular volume ( 29403010 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 27863252 32888494) Red cell distribution width ( 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)	Blood urea nitrogen levels ( 31152163) Proteinuria and chronic kidney disease ( 26420894) Refractive error ( 32231278)
Interacting Genes		32 interacting genes: ARID1A C1QBP CCDC57 CREBBP CSNK2A1 CSNK2A2 DVL3 EFEMP2 EP300 FLI1 GYS1 HDAC1 HNRNPF HNRNPK MKRN3 PATZ1 PCBP1 PRKACA PRR3 RBM10 RBM4B RBPMS2 SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCE1 SNRPC TIAL1 TLE5 VPS37C	148 interacting genes: ABI1 ABI2 ABLIM1 AMOTL2 ANKRD23 AQP1 ARID5A ARL4A AXIN1 BCAR3 BEX2 C19orf44 CATSPERT CBX8 CBY2 CCDC120 CCDC33 CDC20B CEP57L1 CFAP53 COIL CRTC2 CWF19L2 DCLK2 DISC1 DTX2 ECPAS EFHC2 EIF3D EIF4G1 ELOA EMILIN3 ESS2 FAM107A FAM161A FAM161B FAM228A FAM50B FAM90A1 FH FOXD4L1 FTO GFAP GIGYF1 GPBP1 GPKOW GRPEL1 HAUS1 HBA2 HDX IHO1 IKZF3 INCA1 INTS2 JRK KANK2 KIAA0408 KLF1 KLF15 KPRP KRT4 KRT76 KRTAP13-2 KRTAP13-3 LENG1 LINC00526 LZTS1 MAD1L1 MDM1 MFAP1 MT1E MYOZ3 NAB2 NAPRT NCOA5 NELFE NME4 NUMA1 PAK5 PER1 POM121 PPHLN1 PPP1R18 PRAM1 PRDM6 PROSER3 PRPF18 PRPF31 PRR3 PSMB4 PTCHD3 PTPN7 RAB3IL1 RASD1 RBM48 RDM1 RINT1 RNF6 ROBO3 RUSC1 RXRB SAXO4 SFI1 SH3KBP1 SHISA6 SIRPA SLC25A48 SMG9 SNRNP35 SORBS3 SPMIP2 SPMIP6 SPRY1 SYT6 TBC1D22B TCP10L TFIP11 TFPT TIMM44 TLE5 TMEM100 TNNI1 TP53BP2 TRIM14 TRIM29 TSEN54 TSGA10IP TSHZ2 TXLNA USP15 USP2 UTP14C VPS52 YJU2 ZBTB4 ZC2HC1C ZFC3H1 ZGPAT ZMAT2 ZNF417 ZNF436 ZNF474 ZNF552 ZNF648 ZNF655 ZNF688 ZNF835 ZSWIM3
Entrez ID		10661	284001
HPRD ID		07197	14150
Ensembl ID		ENSG00000105610	ENSG00000176155
Uniprot IDs		Q13351	A0A590UJT6 Q2TAC2
PDB IDs		2L2I 2MBH 2N23
Enriched GO Terms of Interacting Partners?		NpBAF Complex NBAF Complex Nucleosome Disassembly Protein-DNA Complex Disassembly Regulation Of Nucleotide-excision Repair SWI/SNF Complex Brahma Complex Regulation Of Double-strand Break Repair RSC-type Complex Regulation Of G0 To G1 Transition Regulation Of Chromosome Segregation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Stem Cell Population Maintenance BBAF Complex Regulation Of DNA Repair Positive Regulation Of Double-strand Break Repair Positive Regulation Of T Cell Differentiation Regulation Of Stem Cell Population Maintenance Nucleosomal DNA Binding Regulation Of Myoblast Differentiation Regulation Of Cellular Response To Stress Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of DNA Repair Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Transcription By RNA Polymerase II Regulation Of Sister Chromatid Segregation Regulation Of T Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coactivator Activity Chromatin Positive Regulation Of Leukocyte Differentiation Regulation Of RNA Metabolic Process Nucleosome Organization Regulation Of Lymphocyte Differentiation Nucleoplasm Protein-containing Complex Disassembly Regulation Of Primary Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of Cell Adhesion Chromatin Remodeling Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Biosynthetic Process Positive Regulation Of T Cell Activation Regulation Of Gene Expression Regulation Of DNA-templated Transcription Positive Regulation Of DNA Metabolic Process Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle G1/S Phase Transition	Protein Binding Spliceosomal Complex Nucleus Cytoskeleton MRNA Splicing, Via Spliceosome RNA Splicing Axonemal A Tubule Inner Sheath RNA Splicing, Via Transesterification Reactions
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