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GYS1 and INCA1
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
GYS1
INCA1
Description
glycogen synthase 1
inhibitor of CDK, cyclin A1 interacting protein 1
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Membrane
Inclusion Body
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Body
Molecular Function
Catalytic Activity
Alpha-1,4-glucan Glucosyltransferase (UDP-glucose Donor) Activity
Protein Binding
D-glucose Binding
Transferase Activity
Glycosyltransferase Activity
Glycogen Synthase Activity, Transferring Glucose-1-phosphate
Protein Kinase Inhibitor Activity
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Cyclin Binding
Identical Protein Binding
Protein-containing Complex Binding
Biological Process
Glycogen Metabolic Process
Glycogen Biosynthetic Process
Heart Development
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Fibroblast Proliferation
Negative Regulation Of Fibroblast Proliferation
Apoptotic Signaling Pathway
Positive Regulation Of Apoptotic Signaling Pathway
Pathways
Glycogen synthesis
Myoclonic epilepsy of Lafora
Glycogen storage disease type XV (GYG1)
Glycogen storage disease type 0 (muscle GYS1)
Drugs
Diseases
Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS
Intraocular pressure (
29235454
)
Keratoconus (
33649486
)
Obesity-related traits (
23251661
)
Interacting Genes
43 interacting genes:
AIMP2
APP
BEND7
CCDC33
CDCA8
CLVS2
CRX
CSNK2A1
EFHC2
FAM228A
GSK3B
GYG1
GYG2
HOXB6
HOXC8
IHO1
INCA1
KATNBL1
KLF1
KLF4
MAPKAPK5
MEOX1
NDUFB7
NHLRC1
PCYT1A
PINX1
PLAGL2
PNMA5
PRKACA
RBM48
SNIP1
SORBS3
SUMO2
TFAP2D
TLE5
WASHC1
ZBTB33
ZNF212
ZNF326
ZNF474
ZNF552
ZNF620
ZNF774
236 interacting genes:
ABI2
ACTMAP
ACY3
AKAP8L
ANKRD28
ARMC7
ASPSCR1
ATG5
ATP6V0D2
ATPAF2
BAG3
BANF2
BOLA3
BPIFA1
C10orf55
C1orf35
C1orf50
C1orf56
C22orf39
CABP5
CCBE1
CCDC57
CCDC78
CCNA1
CDA
CDC23
CDK18
CDK2
CDK4
CDKN1A
CDKN2B
CDKN2D
CEP72
CHCHD2
CHCHD5
CHRD
CINP
CKS1B
CLIC3
CLK3
COL8A1
CPSF1
CSDC2
CSTF2
CTNNBIP1
CTTNBP2
CYSRT1
DAZAP2
DEF6
DMRT3
DMRTB1
DOK4
DPH7
DUSP13B
EFEMP2
EMD
EPHB6
EXOSC8
FAAP20
FAIM
FEM1A
FGF16
FHL2
FMR1
FRS3
GEM
GEMIN2
GRB2
GRXCR1
GSTO2
GTF2H5
GTPBP3
GYS1
HAUS1
HCK
HDAC4
HEMK1
HENMT1
HNRNPF
HOMER3
HOXA1
HR
HSD17B14
HYI
IL36RN
ILF2
KCTD7
KCTD9
KIAA1217
KIR2DL4
KLHL26
KLHL42
KRT33B
KRT5
KRT75
KRTAP15-1
KRTAP19-1
KRTAP19-5
KRTAP19-6
KRTAP5-6
KRTAP6-2
KRTAP6-3
KRTAP9-3
LENG8
LGALS3
LHX3
LMNTD2
LMO2
LMO3
LSM3
LYPLA2
MAD2L2
MAGED4B
MAGOHB
MALSU1
MARF1
MARK1
MATN3
MBLAC1
METAP1
MPP1
MSRB1
MTMR9
NATD1
NCK2
NDUFAF3
NEDD9
NEIL2
NEK6
NFKBID
NHSL2
NME7
NMRK1
NPAS2
NTAQ1
NUBP2
NUDT16L1
NUDT22
OR6B1
OSGIN1
PADI3
PATE1
PCSK5
PCYT2
PDP1
PEF1
PFDN5
PHF1
PLA2G10
PLSCR3
POLR1C
POLR3C
POP5
POU4F2
PRPH
PSMB2
PSMB8
PTGER3
R3HDM2
RAB5C
RALB
RAMAC
RBPMS
RECK
RFC3
RIPPLY3
RNF26
SAP18
SAXO4
SCNM1
SEC14L4
SHFL
SLC67A1-AS
SMG9
SMUG1
SNRPB
SPAG8
SPG21
SPOUT1
SPRY1
STAMBPL1
STK16
STT3B
SUOX
TBC1D7
TCL1A
TEAD4
TEKT4
TEX12
TFAP2A
TFAP2D
TFAP4
TFG
THAP6
THRSP
TIAL1
TPRX1
TRAPPC2
TRAPPC2B
TRAPPC6A
TRIB3
TRIM26
TRIM55
TRIM63
TRIM68
TRIP13
TRIP6
TSEN15
TSG101
TSSK3
TSTD2
TXNDC17
UBASH3B
UBE2D4
UBE2Z
UBTD2
UBXN2B
UFM1
UFSP1
VEZF1
VGLL3
VPS26C
VPS28
WWOX
YIPF3
YOD1
ZDHHC24
ZFAND3
ZMYND12
ZMYND19
ZNF205-AS1
ZNF32
ZNF446
ZNF747
ZNF765
ZNRD2
Entrez ID
2997
388324
HPRD ID
00721
17150
Ensembl ID
ENSG00000104812
ENSG00000196388
Uniprot IDs
P13807
Q0VD86
PDB IDs
7Q0B
7Q0S
7Q12
7Q13
7ZBN
8CVX
8CVY
8CVZ
Enriched GO Terms of Interacting Partners
?
Nucleus
Regulation Of Transcription By RNA Polymerase II
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of Primary Metabolic Process
Regulation Of RNA Biosynthetic Process
Glycogenin Glucosyltransferase Activity
Regulation Of Macromolecule Metabolic Process
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Glycogen Biosynthetic Process
Glycogen Metabolic Process
Regulation Of RNA Metabolic Process
DNA Binding
Polysaccharide Biosynthetic Process
Protein Binding
Regulation Of Macromolecule Biosynthetic Process
DNA-binding Transcription Factor Activity
Energy Reserve Metabolic Process
Polysaccharide Metabolic Process
Regulation Of Metabolic Process
Regulation Of Gene Expression
Energy Derivation By Oxidation Of Organic Compounds
Regulation Of Protein Ubiquitination
Regulation Of Protein Metabolic Process
Cellular Response To Endothelin
Positive Regulation Of Apoptotic Process
Regulation Of Post-translational Protein Modification
Response To Endothelin
Positive Regulation Of Programmed Cell Death
Regulation Of Apoptotic Signaling Pathway
Wnt Signaling Pathway
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Positive Regulation Of Neuron Apoptotic Process
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Positive Regulation Of Transcription By RNA Polymerase II
Cellular Response To Laminar Fluid Shear Stress
Regulation Of Cell Cycle
Generation Of Precursor Metabolites And Energy
Positive Regulation Of Protein Export From Nucleus
Protein Binding
Intermediate Filament
Cytosol
COPII Vesicle Coating
Spindle Pole Centrosome
Cytoplasm
Nucleus
Identical Protein Binding
Cyclin A1-CDK2 Complex
MRNA Processing
Vesicle Coating
Positive Regulation Of Ubiquitin-dependent Endocytosis
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