GYS1 and ZBTB33

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GYS1	ZBTB33
Description		glycogen synthase 1	zinc finger and BTB domain containing 33
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GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Inclusion Body	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Catalytic Activity Alpha-1,4-glucan Glucosyltransferase (UDP-glucose Donor) Activity Protein Binding D-glucose Binding Transferase Activity Glycosyltransferase Activity Glycogen Synthase Activity, Transferring Glucose-1-phosphate	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Methyl-CpG Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Glycogen Metabolic Process Glycogen Biosynthetic Process Heart Development	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Regulation Of Immune System Process Wnt Signaling Pathway Intracellular Signal Transduction Negative Regulation Of DNA-templated Transcription
Pathways		Glycogen synthesis Myoclonic epilepsy of Lafora Glycogen storage disease type XV (GYG1) Glycogen storage disease type 0 (muscle GYS1)	Negative Regulation of CDH1 Gene Transcription
Drugs
Diseases		Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS
Interacting Genes		43 interacting genes: AIMP2 APP BEND7 CCDC33 CDCA8 CLVS2 CRX CSNK2A1 EFHC2 FAM228A GSK3B GYG1 GYG2 HOXB6 HOXC8 IHO1 INCA1 KATNBL1 KLF1 KLF4 MAPKAPK5 MEOX1 NDUFB7 NHLRC1 PCYT1A PINX1 PLAGL2 PNMA5 PRKACA RBM48 SNIP1 SORBS3 SUMO2 TFAP2D TLE5 WASHC1 ZBTB33 ZNF212 ZNF326 ZNF474 ZNF552 ZNF620 ZNF774	9 interacting genes: CBFA2T3 CTNND1 GSDMD GYS1 NCOR1 NUDT22 SUMO2 SUMO3 TRIM28
Entrez ID		2997	10009
HPRD ID		00721	02269
Ensembl ID		ENSG00000104812	ENSG00000177485
Uniprot IDs		P13807	Q86T24
PDB IDs		7Q0B 7Q0S 7Q12 7Q13 7ZBN 8CVX 8CVY 8CVZ	2LT7 3FKC 3M4T 3M8V 4F6M 4F6N 5VMU 5VMV 5VMW 5VMX 5VMY 5VMZ 6DF5 6DF8 6DF9 6DFA 6DFB 6DFC 6V8U
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Glycogenin Glucosyltransferase Activity Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Glycogen Biosynthetic Process Glycogen Metabolic Process Regulation Of RNA Metabolic Process DNA Binding Polysaccharide Biosynthetic Process Protein Binding Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Energy Reserve Metabolic Process Polysaccharide Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Energy Derivation By Oxidation Of Organic Compounds Regulation Of Protein Ubiquitination Regulation Of Protein Metabolic Process Cellular Response To Endothelin Positive Regulation Of Apoptotic Process Regulation Of Post-translational Protein Modification Response To Endothelin Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Wnt Signaling Pathway RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Neuron Apoptotic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Laminar Fluid Shear Stress Regulation Of Cell Cycle Generation Of Precursor Metabolites And Energy Positive Regulation Of Protein Export From Nucleus	Protein Sumoylation Negative Regulation Of Glycolytic Process Regulation Of Generation Of Precursor Metabolites And Energy Protein Tag Activity SUMO Transferase Activity Negative Regulation Of D-glucose Transmembrane Transport Negative Regulation Of ATP Metabolic Process Ubiquitin-like Protein Ligase Binding Transcription Corepressor Activity Regulation Of Glycolytic Process Negative Regulation Of Blood Vessel Branching Structural Constituent Of Presynaptic Actin Cytoskeleton GDP-mannose Hydrolase Activity Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of ATP Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of D-glucose Transmembrane Transport Glycogen Synthase Activity, Transferring Glucose-1-phosphate Krueppel-associated Box Domain Binding Derlin-1-VIMP Complex UDP-sugar Diphosphatase Activity Alpha-1,4-glucan Glucosyltransferase (UDP-glucose Donor) Activity Ubiquitin-like Protein Ligase Activity Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process PML Body Negative Regulation Of Small Molecule Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Transmembrane Transport Positive Regulation Of Protein Localization To Cell-cell Junction Embryonic Placenta Morphogenesis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Localization To Cell-cell Junction Presynaptic Actin Cytoskeleton Organization Actin Filament Network Formation Convergent Extension Involved In Axis Elongation Chromo Shadow Domain Binding Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus
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