GYPC and TSPAN15

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		GYPC	TSPAN15
Name		glycophorin C (Gerbich blood group)	tetraspanin 15
Structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Cortical Cytoskeleton	Endosome Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Cell Surface Membrane Nuclear Body Cell Junction Late Endosome Membrane Tetraspanin-enriched Microdomain
	Molecular Function	Protein Binding	Protein Binding Enzyme Binding
	Biological Process	None	Regulation Of Notch Signaling Pathway Negative Regulation Of Notch Signaling Pathway Regulation Of Membrane Protein Ectodomain Proteolysis Protein Maturation Protein Localization To Plasma Membrane
Pathways		Cell surface interactions at the vascular wall	Amyloid fiber formation
GWAS		Atrial fibrillation ( 29892015 30061737 ) Diastolic blood pressure ( 30224653 ) Hemoglobin levels ( 32327693 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Initial pursuit acceleration ( 29064472 ) Intelligence ( 22449649 ) Metabolite levels ( 23823483 ) Pelvic organ prolapse (moderate/severe) ( 26545240 ) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Systolic blood pressure ( 31217584 ) Tea consumption ( 31046077 )	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Height ( 31562340 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Immature fraction of reticulocytes ( 32888494 ) Response to taxane treatment (paclitaxel) ( 23006423 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Thrombosis ( 26908601 ) Type 2 diabetes ( 32499647 ) Venous thromboembolism ( 25772935 28373160 31420334 31676865 )
Novel Interactors		None recorded	9 novel interactors: ADAMDEC1 CHI3L1 KLRC3 RUFY2 SERBP1 SETDB1 SLC25A16 TCHP TSPO
Interacting Genes		13 interacting genes: ABHD16A AQP6 EPB41 GPR42 MPP1 PDIA3 PLPPR2 RHBDD1 SHISAL1 SLC10A6 TMEM14B TMEM88 TSPAN15	5 interacting genes: BTRC GYPC RGS2 STRIT1 SYNE4
Entrez ID		2995	23555
HPRD ID		00193	15511
Ensembl ID		ENSG00000136732	ENSG00000099282
Uniprot IDs		P04921	O95858
PDB IDs		2EJY	7RD5 7RDB 8ESV
GO Terms Enriched among Interactors		PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport Membrane Cortical Cytoskeleton Tapasin-ERp57 Complex Phosphatidylserine Catabolic Process Prostaglandin Catabolic Process Membrane Protein Proteolysis Involved In Retrograde Protein Transport, ER To Cytosol Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport	None