TSPAN15 and CHI3L1

		TSPAN15	CHI3L1
Description		tetraspanin 15	chitinase 3 like 1
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GO Annotations	Cellular Component	Endosome Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Cell Surface Membrane Nuclear Body Cell Junction Late Endosome Membrane Tetraspanin-enriched Microdomain	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Extracellular Matrix Specific Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Enzyme Binding	Chitinase Activity Extracellular Matrix Structural Constituent Protein Binding Chitin Binding Carbohydrate Binding
	Biological Process	Regulation Of Notch Signaling Pathway Negative Regulation Of Notch Signaling Pathway Regulation Of Membrane Protein Ectodomain Proteolysis Protein Maturation Protein Localization To Plasma Membrane	Carbohydrate Metabolic Process Chitin Catabolic Process Apoptotic Process Inflammatory Response Activation Of NF-kappaB-inducing Kinase Activity Response To Mechanical Stimulus Positive Regulation Of Peptidyl-threonine Phosphorylation Lung Development Positive Regulation Of Interleukin-8 Production Response To Tumor Necrosis Factor Positive Regulation Of Angiogenesis Cartilage Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-1 Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor
Pathways		Amyloid fiber formation	Neutrophil degranulation
Drugs
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 31562340) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Response to taxane treatment (paclitaxel) ( 23006423) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Thrombosis ( 26908601) Type 2 diabetes ( 32499647) Venous thromboembolism ( 25772935 28373160 31420334 31676865)	Asthma ( 31959851) Blood protein levels in cardiovascular risk ( 28369058) Clozapine-induced agranulocytosis ( 25187353) Metabolite levels ( 23823483) YKL-40 levels ( 18403759)
Interacting Genes		5 interacting genes: BTRC GYPC RGS2 STRIT1 SYNE4
Entrez ID		23555	1116
HPRD ID		15511	03314
Ensembl ID		ENSG00000099282	ENSG00000133048
Uniprot IDs		O95858	P36222
PDB IDs		7RD5 7RDB 8ESV	1HJV 1HJW 1HJX 1NWR 1NWS 1NWT 1NWU 7CJ2 8DF1 8R41 8R42 8R4X
Enriched GO Terms of Interacting Partners?			Tetraspanin-enriched Microdomain Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Notch Signaling Pathway
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