TSPAN15 and ADAMDEC1

		TSPAN15	ADAMDEC1
Description		tetraspanin 15	ADAM like decysin 1
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Cell Surface Membrane Nuclear Body Cell Junction Late Endosome Membrane Tetraspanin-enriched Microdomain	Extracellular Region Extracellular Matrix
	Molecular Function	Protein Binding Enzyme Binding	Metalloendopeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Regulation Of Notch Signaling Pathway Negative Regulation Of Notch Signaling Pathway Regulation Of Membrane Protein Ectodomain Proteolysis Protein Maturation Protein Localization To Plasma Membrane	Proteolysis Immune Response Negative Regulation Of Cell Adhesion
Pathways		Amyloid fiber formation
Drugs
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 31562340) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Response to taxane treatment (paclitaxel) ( 23006423) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Thrombosis ( 26908601) Type 2 diabetes ( 32499647) Venous thromboembolism ( 25772935 28373160 31420334 31676865)	Hair greying ( 26926045)
Interacting Genes		5 interacting genes: BTRC GYPC RGS2 STRIT1 SYNE4
Entrez ID		23555	27299
HPRD ID		15511	07070
Ensembl ID		ENSG00000099282	ENSG00000134028
Uniprot IDs		O95858	B7Z6V5 O15204
PDB IDs		7RD5 7RDB 8ESV
Enriched GO Terms of Interacting Partners?			GPI-anchor Transamidase Activity GPI-anchor Transamidase Complex Protein Maturation Attachment Of GPI Anchor To Protein GPI Anchor Binding GPI Anchored Protein Biosynthesis Protein Retention In ER Lumen Tetraspanin-enriched Microdomain Maintenance Of Protein Localization In Endoplasmic Reticulum GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Regulation Of Membrane Protein Ectodomain Proteolysis Maintenance Of Protein Localization In Organelle Negative Regulation Of Notch Signaling Pathway Maintenance Of Protein Location In Cell Maintenance Of Protein Location Glycolipid Biosynthetic Process Maintenance Of Location In Cell Maintenance Of Location Glycolipid Metabolic Process Regulation Of Notch Signaling Pathway Phosphatidylinositol Biosynthetic Process
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