TSPAN15 and KLRC3

		TSPAN15	KLRC3
Description		tetraspanin 15	killer cell lectin like receptor C3
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Cell Surface Membrane Nuclear Body Cell Junction Late Endosome Membrane Tetraspanin-enriched Microdomain	Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex
	Molecular Function	Protein Binding Enzyme Binding	Transmembrane Signaling Receptor Activity Carbohydrate Binding
	Biological Process	Regulation Of Notch Signaling Pathway Negative Regulation Of Notch Signaling Pathway Regulation Of Membrane Protein Ectodomain Proteolysis Protein Maturation Protein Localization To Plasma Membrane	Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Defense Response Regulation Of Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Pathways		Amyloid fiber formation
Drugs
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 31562340) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Response to taxane treatment (paclitaxel) ( 23006423) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Thrombosis ( 26908601) Type 2 diabetes ( 32499647) Venous thromboembolism ( 25772935 28373160 31420334 31676865)	Aspartate aminotransferase levels ( 33547301) Composite immunoglobulin trait (IgA/IgG) ( 28628107) Mean corpuscular volume ( 27863252)
Interacting Genes		5 interacting genes: BTRC GYPC RGS2 STRIT1 SYNE4	3 interacting genes: KLRD1 RHOU TYROBP
Entrez ID		23555	3823
HPRD ID		15511	04203
Ensembl ID		ENSG00000099282	ENSG00000205810
Uniprot IDs		O95858	Q07444
PDB IDs		7RD5 7RDB 8ESV
Enriched GO Terms of Interacting Partners?			Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Activation Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Lymphocyte Mediated Immunity HLA-E Specific Inhibitory MHC Class Ib Receptor Activity MHC Class Ib Protein Binding, Via Antigen Binding Groove Leukocyte Mediated Immunity Stimulatory Killer Cell Immunoglobulin-like Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Osteoclast Development Positive Regulation Of Microglial Cell Mediated Cytotoxicity Protein-macromolecule Adaptor Activity Positive Regulation Of Receptor Localization To Synapse Positive Regulation Of Macrophage Fusion Microglial Cell Activation Involved In Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune Effector Process Negative Regulation Of Transforming Growth Factor Beta1 Production Immune Response-regulating Cell Surface Receptor Signaling Pathway MHC Class I Protein Complex Binding Positive Regulation Of Innate Immune Response T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Focal Adhesion Disassembly Protein Antigen Binding Regulation Of Osteoclast Development Tetraspanin-enriched Microdomain Negative Regulation Of T Cell Mediated Cytotoxicity Immune Response-activating Signaling Pathway Neutrophil Activation Involved In Immune Response Negative Regulation Of Long-term Synaptic Potentiation Actin Cytoskeleton Organization Negative Regulation Of Transforming Growth Factor Beta Production Immune Effector Process Immune Response-regulating Signaling Pathway Actin Filament-based Process Activation Of Immune Response Regulation Of Innate Immune Response Negative Regulation Of B Cell Proliferation Endocytosis Positive Regulation Of Defense Response Positive Regulation Of Protein Localization To Cell Surface Macrophage Activation Involved In Immune Response Positive Regulation Of Superoxide Anion Generation Plasma Membrane
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