TSPAN15 and RUFY2

		TSPAN15	RUFY2
Description		tetraspanin 15	RUN and FYVE domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Cell Surface Membrane Nuclear Body Cell Junction Late Endosome Membrane Tetraspanin-enriched Microdomain	Nucleus Cytoplasm Endosome
	Molecular Function	Protein Binding Enzyme Binding	Protein Binding Zinc Ion Binding SH3 Domain Binding Metal Ion Binding
	Biological Process	Regulation Of Notch Signaling Pathway Negative Regulation Of Notch Signaling Pathway Regulation Of Membrane Protein Ectodomain Proteolysis Protein Maturation Protein Localization To Plasma Membrane	Regulation Of Endocytosis
Pathways		Amyloid fiber formation
Drugs
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 31562340) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Response to taxane treatment (paclitaxel) ( 23006423) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Thrombosis ( 26908601) Type 2 diabetes ( 32499647) Venous thromboembolism ( 25772935 28373160 31420334 31676865)	Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		5 interacting genes: BTRC GYPC RGS2 STRIT1 SYNE4	7 interacting genes: BMX DSCAM DUSP23 EPHA3 RAB33A RAB33B SF3B3
Entrez ID		23555	55680
HPRD ID		15511	11526
Ensembl ID		ENSG00000099282	ENSG00000204130
Uniprot IDs		O95858	Q5GIA6 Q8WXA3
PDB IDs		7RD5 7RDB 8ESV
Enriched GO Terms of Interacting Partners?			Rab Protein Signal Transduction Neuron Recognition Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Fasciculation Of Motor Neuron Axon Autophagosome Organization Autophagosome Assembly Negative Regulation Of Constitutive Secretory Pathway Regulation Of Retrograde Vesicle-mediated Transport, Golgi To ER Protein Tyrosine Kinase Activity Cell Recognition Fasciculation Of Sensory Neuron Axon
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