GYPC and TMEM88

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		GYPC	TMEM88
Name		glycophorin C (Gerbich blood group)	transmembrane protein 88
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Cortical Cytoskeleton	Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding	Protein Binding PDZ Domain Binding
	Biological Process	None	Wnt Signaling Pathway Protein Stabilization Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Cell surface interactions at the vascular wall	None
GWAS		Atrial fibrillation ( 29892015 30061737 ) Diastolic blood pressure ( 30224653 ) Hemoglobin levels ( 32327693 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Initial pursuit acceleration ( 29064472 ) Intelligence ( 22449649 ) Metabolite levels ( 23823483 ) Pelvic organ prolapse (moderate/severe) ( 26545240 ) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Systolic blood pressure ( 31217584 ) Tea consumption ( 31046077 )	Brain morphology (MOSTest) ( 32665545 )
Interacting Genes		13 interacting genes: ABHD16A AQP6 EPB41 GPR42 MPP1 PDIA3 PLPPR2 RHBDD1 SHISAL1 SLC10A6 TMEM14B TMEM88 TSPAN15	9 interacting genes: GYPC MFF NKG7 TIMM23 TMEM11 TMEM218 TMEM50B VRK2 ZDHHC22
Entrez ID		2995	92162
HPRD ID		00193	17438
Ensembl ID		ENSG00000136732	ENSG00000167874
Uniprot IDs		P04921	I3L2J3 Q6PEY1
PDB IDs		2EJY	Not available
GO Terms Enriched among Interactors		PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport Membrane Cortical Cytoskeleton Tapasin-ERp57 Complex Phosphatidylserine Catabolic Process Prostaglandin Catabolic Process Membrane Protein Proteolysis Involved In Retrograde Protein Transport, ER To Cytosol Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport	Protein Targeting Protein Targeting To Mitochondrion Membrane Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Organelle Envelope Establishment Of Protein Localization To Mitochondrion