MYLIP and TSC22D4

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		MYLIP	TSC22D4
Gene Name		myosin regulatory light chain interacting protein	TSC22 domain family, member 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Cytoplasm Cytoskeleton Plasma Membrane Extrinsic Component Of Membrane	Nucleus Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Cytoskeletal Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Activity	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Movement Of Cell Or Subcellular Component Nervous System Development Negative Regulation Of Low-density Lipoprotein Particle Clearance Protein Ubiquitination Protein Destabilization Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cholesterol Homeostasis Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process	Transcription, DNA-templated Response To Osmotic Stress Negative Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS		LDL cholesterol ( 20864672) Major depressive disorder ( 23377640) Response to statin therapy (LDL-C) ( 22331829)
Protein-Protein Interactions		15 interactors: CNPY2 KDM1A LDLR LRP8 MIPOL1 MTAP MYL12B RASSF5 TSC22D4 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2N VLDLR	53 interactors: ABLIM1 AES AIFM1 APIP BLZF1 BZRAP1 CCDC146 CCDC33 CCDC42 CCNK CDC23 CDK5R1 CKS2 CLU ENKD1 FRMD6 FXR2 GNB2L1 GOLGA2 GORASP2 KEAP1 KPNA2 KRT40 LBP LMO2 LNX1 LRP2BP MAD2L1 MTHFS MYLIP NIF3L1 NOC4L NRBP1 NRBP2 PCBP1 PIH1D1 PIN1 POLR1C PPL PRKAA1 PRKAA2 PRNP PSMA1 SACS SAT1 SMAD3 SYT17 TEX11 TSC22D1 UBLCP1 ZBTB24 ZMYND10 ZNF580
Entrez ID		29116	81628
HPRD ID		17621	18231
Ensembl ID		ENSG00000007944	ENSG00000166925
Uniprot IDs		Q5TIA5 Q8WY64	A8MWR6 Q9Y3Q8
PDB IDs		2YHN 2YHO
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Protein Polyubiquitination Toll-like Receptor 4 Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Negative Regulation Of Gene Expression Regulation Of DNA-templated Transcription In Response To Stress Reelin-mediated Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Innate Immune Response Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Positive Regulation Of Cellular Metabolic Process Cellular Response To Oxygen Levels Positive Regulation Of Protein Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Ubiquitination Negative Regulation Of Biosynthetic Process Protein K11-linked Ubiquitination Regulation Of Protein Metabolic Process Positive Regulation Of Immune System Process Response To Stimulus Positive Regulation Of Protein Modification Process Immune Response-regulating Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Protein K63-linked Ubiquitination Modification-dependent Protein Catabolic Process Plasma Lipoprotein Particle Clearance Regulation Of Protein Ubiquitination Regulation Of Chromosome Organization Positive Regulation Of Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Transferase Activity Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process	Cell Cycle Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Cell Cycle Negative Regulation Of Cell Death Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Proteolysis Negative Regulation Of Cell Cycle Positive Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Cellular Process Cell Cycle Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Ubiquitination Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cytokine Production Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Ubiquitination Negative Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Cell Death Regulation Of Protein Phosphorylation Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cell Cycle Arrest Negative Regulation Of Signal Transduction Nitrogen Compound Metabolic Process Regulation Of Energy Homeostasis Negative Regulation Of Protein Metabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Glycolytic Process Cellular Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		aa absorption achieve atorvastatin brazilian carrying cholesterol curve dyslipidemia ezetimibe familial fh ga genotype genotypes gg heterozygous hypercholesterolemia ldl ldlr limiting lowering melting myosin n342s pharmacogenetic rs9370867 scenario variations	ablation cachectic cachexia clone deprivation diminished hepatic hepatocytes hypertriglyceridemia hypo hypobetalipoproteinemia lipids lipogenic livers mammals metabolic mimicking output proper rationale rescued secretion storage transforming triggers vldl wasting
Tagcloud (Difference) ?		aa absorption achieve atorvastatin brazilian carrying cholesterol curve dyslipidemia ezetimibe familial fh ga genotype genotypes gg heterozygous hypercholesterolemia ldl ldlr limiting lowering melting myosin n342s pharmacogenetic rs9370867 scenario variations	ablation cachectic cachexia clone deprivation diminished hepatic hepatocytes hypertriglyceridemia hypo hypobetalipoproteinemia lipids lipogenic livers mammals metabolic mimicking output proper rationale rescued secretion storage transforming triggers vldl wasting
Tagcloud (Intersection) ?