MYLIP and VLDLR

Number of citations of the paper that reports this interaction (PubMedID 22109552)
19

Data Source:
BioGRID (unspecified method)

		MYLIP	VLDLR
Description		myosin regulatory light chain interacting protein	very low density lipoprotein receptor
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane	Extracellular Space Lysosomal Membrane Plasma Membrane Clathrin-coated Pit Membrane Very-low-density Lipoprotein Particle Receptor Complex Synapse Glutamatergic Synapse
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Cytoskeletal Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding Very-low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Very-low-density Lipoprotein Particle Binding Cargo Receptor Activity Reelin Receptor Activity Calcium-dependent Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Nervous System Development Negative Regulation Of Neuron Projection Development Negative Regulation Of Low-density Lipoprotein Particle Clearance Protein Ubiquitination Protein Destabilization Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cholesterol Homeostasis Positive Regulation Of Protein Catabolic Process	Lipid Metabolic Process Lipid Transport Endocytosis Receptor-mediated Endocytosis Signal Transduction Nervous System Development Memory Steroid Metabolic Process Cholesterol Metabolic Process Ventral Spinal Cord Development Glycoprotein Transport Very-low-density Lipoprotein Particle Clearance Reelin-mediated Signaling Pathway Dendrite Morphogenesis Regulation Of Synapse Assembly Positive Regulation Of Dendrite Development
Pathways		VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake Antigen processing: Ubiquitination & Proteasome degradation	Reelin signalling pathway VLDLR internalisation and degradation VLDL clearance
Drugs			Lauric acid
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Cholesterol, total ( 24097068) Diisocyanate-induced asthma ( 25918132) Femoral neck bone mineral density ( 30172743) LDL cholesterol ( 20864672 24097068 25961943) LDL cholesterol levels ( 32203549 30698716 28334899) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Major depressive disorder ( 23377640) Medication use (HMG CoA reductase inhibitors) ( 31015401) Response to statins (LDL cholesterol change) ( 22331829) Total cholesterol levels ( 28334899)	Alzheimer's disease (age of onset) ( 22005931) Apolipoprotein B levels ( 32203549) Cholesterol, total ( 24097068) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Gambling ( 22780124) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Inflammatory biomarkers (multivariate analysis) ( 33110245) LDL cholesterol ( 30275531 24097068) LDL cholesterol levels ( 28334899 32203549) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Systolic blood pressure ( 26969751) Total cholesterol levels ( 30275531) Vascular endothelial growth factor levels ( 21757650 31217265 27989323 26910538) White blood cell count ( 32888494) White coat effect (clinic diastolic blood pressure minus ambulatory diastolic blood pressure) ( 31044621)
Interacting Genes		42 interacting genes: ADAMTSL4 AR ARID5A CNPY2 CRK DAPP1 DDIT4L EFHC2 EXOSC5 FAM217B GMCL1 HOOK2 INO80B KANK4 KDM1A LDLR LNX2 LRP8 MIPOL1 MTAP MYL12B NHLRC4 NOXA1 NR1D2 PAX9 RASSF5 SCNM1 SDCBP SRPK2 TCEANC TSC1 TSC22D4 UBE2D2 UBE2D3 UBE2D4 UBE2N VLDLR ZBTB16 ZBTB18 ZBTB42 ZNF417 ZNF438	12 interacting genes: APOE CD36 CLU DAB1 DYRK1A ITSN1 LPL LRPAP1 MYLIP RELN SNX17 ZSCAN12
Entrez ID		29116	7436
HPRD ID		17621	01895
Ensembl ID		ENSG00000007944	ENSG00000147852
Uniprot IDs		Q5TIA5 Q8WY64	A0A7P0T897 A0A7P0T8N9 A0A7P0T9P7 P98155 Q5VVF5
PDB IDs		2YHN 2YHO 6QLY 6QLZ	1V9U 3DPR 6BYV 8IHP 8UA4 8UA8 8UFB 8UFC 8X0K 8X0L 8X0M 8XI4 8XI5 8YS2 8YS4 8YVZ 8YW0 8YW1 8YW2
Enriched GO Terms of Interacting Partners?		Very-low-density Lipoprotein Particle Receptor Activity Ubiquitin Conjugating Enzyme Activity Reelin-mediated Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Low-density Lipoprotein Particle Receptor Activity Reelin Receptor Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Protein Binding Cerebral Cortex Development Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Ventral Spinal Cord Development Negative Regulation Of Macromolecule Metabolic Process Nucleus Ubiquitin-protein Transferase Activity Protein-containing Complex Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of Dendrite Development Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Hippocampus Development Cellular Response To Estrogen Stimulus Identical Protein Binding Apolipoprotein Binding Regulation Of Low-density Lipoprotein Particle Clearance	Very-low-density Lipoprotein Particle Receptor Binding Low-density Lipoprotein Particle Receptor Binding Regulation Of Neurofibrillary Tangle Assembly Lipoprotein Particle Binding Receptor Ligand Activity Regulation Of Endocytosis Regulation Of Inclusion Body Assembly Amyloid-beta Binding Regulation Of Amyloid-beta Clearance Positive Regulation Of Neurofibrillary Tangle Assembly Regulation Of Cellular Component Organization Amyloid-beta Clearance Plasma Lipoprotein Particle Clearance Regulation Of Vesicle-mediated Transport Lateral Motor Column Neuron Migration Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Dendritic Spine Development Low-density Lipoprotein Particle Mediated Signaling Spinal Cord Motor Neuron Migration Positive Regulation Of Nitric Oxide Metabolic Process Tau Protein Binding Very-low-density Lipoprotein Particle Clearance Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Endocytosis NMDA Glutamate Receptor Clustering Positive Regulation Of Inclusion Body Assembly Regulation Of Amyloid-beta Formation Negative Regulation Of Cellular Component Organization Regulation Of Amyloid Precursor Protein Catabolic Process Signaling Receptor Binding Regulation Of Dendritic Spine Development Receptor-mediated Endocytosis Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Protein Import Positive Regulation Of Cholesterol Storage Regulation Of Nitric Oxide Biosynthetic Process Very-low-density Lipoprotein Particle Remodeling Positive Regulation Of Amyloid-beta Clearance Cholesterol Catabolic Process Regulation Of Nitric Oxide Metabolic Process Ventral Spinal Cord Development Cholesterol Transport Nitric Oxide-cGMP-mediated Signaling Triglyceride-rich Lipoprotein Particle Remodeling Sterol Transport Regulation Of Amide Metabolic Process Reelin-mediated Signaling Pathway Neurotransmitter-gated Ion Channel Clustering Cholesterol Homeostasis Chylomicron
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